|Grade||Level of Evidence|
|A||Multiple double-blind, controlled clinical trials.|
|B||1 double-blind, controlled clinical trial.|
|C||At least 1 controlled or comparative clinical trial.|
|D||Uncontrolled, observational, animal or in-vitro studies only.|
|Grade||Effect||Size of Effect||Comments|
Salicylic peels have been observed to reduce fine lines, and sodium salicylate significantly reduces wrinkle depth.
Sodium salicylate significantly improves the smoothness of the skin after 4 and 8 weeks of daily application.
Is an effective cure for common warts. Can be used alone or in combination with cryotherapy, pulsed dye laser therapy, alpha hydroxy acids or prescription medications.
Effective in reducing epidermal melasma in Asian skin and in darker skin types when used as superficial chemical peels.
Helps clear acne when used in chemical peelings or as an ingredient in topical products. Also improves postinflammatory hyperpigmentation.
Blocks UVA and UVB radiation, reduces the formation of sunburn cells and DNA damage, and suppresses the development of skin tumours.
Useful in treating plaque psoriasis and scalp psoriasis, either alone or combined with other topical agents or treatment modalities.
Salicylic acid peels lightened post-inflammatory hyperpigmentation in acne patients and faded pigmented spots in aged skin.
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Table of contents:
- 1. Sources
- 2. Bioavailability
- 3. Effects on the skin
- 4. Side Effects
Salicylic acid and related compounds are produced by plants to help defend against pathogen attack and environmental stress. It was first isolated from the willow in the 1830s, and first chemically synthesized in the 1870s. Dietary sources of salicylic acid include fruit, vegetables, tomato-based juices and sauces, fruit juice, tea, wine, and various herbs and spices.
Salicylic acid readily penetrates healthy skin, especially on the cheek, neck and groin area but also on the breast, back, thigh, lower leg and the foot (but not the sole). It penetrates mainly through the transfollicular route.
The vehicle plays an important role in the topical delivery of salicylic acid, with absorptive ointments and collodion formulations delivering a greater amount of salicylic acid across intact skin. Hydrogels, a microgel, an oleogel and a transdermal patch containing salicylic acid and niacinamide has also been developed.
Other techniques that have been explored to enhance or control absorption include the prodrug strategy, a molecular form technique to prepare supersaturated solutions, iontophoresis,, ion-pair formation, the use of different polymers as emulsifiers, and the use of penetration enhancers.
Skin in which the stratum corneum barrier is perturbed due to damage by skin irritants or conditions such as psoriasis show even higher penetration of salicylic acid relative to intact, healthy skin. Repeated applications of salicylic acid at daily intervals also increases its penetration flux.
The mean plasma concentration of salicylic acid after application of a facial peel containing 30% salicylic acid for 5 minutes is 0.81 µg/ml and reaches a maximum of 56.4 µg/ml after 1.4 to 3.5 hours. These values are similar to that observed when a leave-on product containing 2% salicylic acid is applied. Systemically available salicylic acid is eventually eliminated through the urine.
3. Effects on the skin
3.1 Age-related improvements
Salicylic acid helps exfoliate the skin by promoting desquamation of the stratum corneum. It is often used as a superficial chemical peel to resurface photoaged skin, leading to the fading of pigmented spots, decreased surface roughness, reduced fine lines and the removal of lentigines.
In addition, sodium salicylate obtained from neutralizing 1% salicylic acid with sodium hydroxide significantly reduced wrinkle depth and skin roughness compared to placebo after 4 and 8 weeks of daily application. Because salicylic acid can irritate the skin, sodium salicylate is especially suitable for individuals with sensitive skin.
Low-dose 5-fluorouracil in combination with 10% salicylic acid has also been shown in multiple studies to be effective in clearing actinic keratoses, a type of skin lesions arising after chronic sun exposure that can develop into skin cancer. Significantly, this form of therapy demonstrated superior sustained clinical efficacy compared to the combination of 3% diclofenac + hyaluronic acid, as measured by a lower recurrence rate.
Salicylic acid peels provided no additional benefits in improving hyperpigmentation, skin texture, fine lines, skin dryness, skin tone or skin clarity on the neck and upper chest when used with a cream containing 4% hydroquinone and 2% glycolic acid, however.
In vitro experiments have shown that chemical peeling with 30% salicylic acid dissolved in polyethylene glycol led to a reorganization of the epidermis and a rebuilding of the superficial dermal connective tissue in mice skin, and that sodium salicylate stimulated the synthesis of fibrillin and collagen-1 in human skin in vivo. These may explain salicylic acid's wrinkle effacement effect.
Salicylic acid can protect the skin from UV damage. Salicylic acid in petrolatum blocks both UVA and UVB radiation, the main causes of skin aging and sunburn. In experiments on mice, topical application of a 4% salicylic acid cream for 6 weeks raised the dose of solar-simulated light required to induce measurable edema from 90 mJ to 137 mJ, an increase of >50%. Salicylic acid has also been shown to inhibit the activity of inflammatory mediators such as COX-1 and COX-2, reduce the formation of sunburn cells and to promote the removal of thymine-thymine dimers in living skin equivalents.
Furthermore, chemical peeling with salicylic acid is associated with reduced expression of the p53 tumour suppressor protein as well as normalization of keratinocyte differentiation, which may explain why it has been demonstrated to suppress the development of skin tumours. It has also been suggested that chemical peeling with agents such as salicylic acid may prevent tumour formation by removing photodamaged cells.
Concerns over increased sensitivity to UV radiation following the use of skin care products containing salicylic acid may be unwarranted, as treatment with 2% salicylic acid for 3.5 weeks did not lead to significant changes in erythema, DNA damage or sunburn cell formation. It is not clear whether higher concentrations of salicylic acid or longer periods of treatment will increase photosensitivity, however.
3.3 Melasma treatment
Salicylic acid peels can help improve melasma. Peeling with salicylic acid has been shown to be as effective as peeling with Jessner's solution in reducing epidermal melasma. It is also safe and effective on individuals with darker skin. However, the addition of biweekly salicylic acid peels to a regimen of twice daily application of hydroquinone did not provide extra benefits in the treatment of melasma.
3.4 Acne vulgaris treatment
Salicylic acid is useful in acne treatment due to its anti-inflammatory, keratolytic, comedolytic and bacteriostatic effects. Salicylic acid pads reduced the number and severity of acne lesions in 3 placebo-controlled studies, and a clinical trial on 35 Korean patients with facial acne found that treatment with 30% salicylic acid peels on a biweekly basis for 12 weeks decreased the counts of both inflammatory and non-inflammatory acne lesions. The formulation of 30% salicylic acid in a polyethylene vehicle seems to be especially beneficial for chemical peeling, as it led to the disappearance of comedones and papules with minimal inflammation or other adverse effects such as hyperpigmentation or keloids. Salicylic acid peels can also improve post-inflammatory hyperpigmentation, a common sequelae of acne. Full-face peels with 30% salicylic acid biweekly for 3 months successfully lightened postinflammatory hyperpigmentation in the faces of Asian patients with acne.
Salicylic acid appears to aid the treatment of mild-to-moderate acne when incorporated in topical products. A regimen containing a topical blend of salicylic acid + sandalwood oil resulted in notable reductions in acne lesions when used for 8 weeks, and a 1.5% salicylic acid cream improved facial acne in 95% of patients in a separate study.
Salicylic acid may be more effective than benzoyl peroxide in treating acne. In 1 study, patients treated with a 2% salicylic acid cleanser for the first 2 weeks showed a significant improvement in acne due to a reduction in comedones, but their condition worsened when they were treated with a 10% benzoyl peroxide wash over the next 2 weeks. Another study however found 2% salicylic acid + 0.5% chloroxylenol cream to be as effective as 5% benzoyl peroxide gel in reducing papulopustules and comedones.
The effectiveness of salicylic acid + the antibiotic clindamycin has also been evaluated. In a single-blinded clinical trial, treatment of mild-to-moderate acne with a 1% clindamycin + 2% salicylic acid lotion twice daily was significantly more effective than treatment with a 1% clindamycin lotion twice daily, and as effective as treatment with a 1% clindamycin + 0.025% tretinoin lotion once nightly as measured by improvements in the total lesion count and Acne Severity Index.
A meta-analysis of 23 studies involving a total of 7309 patients also revealed that 5% benzoyl peroxide + salicylic acid has comparable efficacy to a combination of benzoyl peroxide + clindamycin in decreasing acne lesions. Moreover, the addition of salicylic acid to treatment with clindamycin phosphate and benzoyl peroxide resulted in significantly better and faster results in diminishing acne lesion counts. Yet another study demonstrated that the combination of salicylic acid + clindamycin phosphate is as effective as tretinoin + clindamycin phosphate in patients with mild to moderate acne vulgaris.
30% salicylic acid peels are at least as effective as Jessner's solution for treating inflammatory and non-inflammatory acne, and had greater therapeutic effect than 50% pyruvic acid peel in reducing facial sebum secretion in acne patients. Further, salicylic-mandelic acid combination peels, a newer treatment modality, is more efficacious on active acne lesions and hyperpigmentation than 35% glycolic acid peels. Peeling with salicylic acid also compared well with peeling with lipohydroxyacid, one of its derivatives. With regards to moderate to severe acne, 20% salicylic acid peels every 2 weeks combined with oral isotretinoin once daily is also more effective than isotretinoin alone.
3.5 Psoriasis treatment
Salicylic acid in gel and foam vehicles have been used to treat psoriasis of the scalp and is a treatment option for chronic plaque psoriasis, the most common type of psoriasis characterized by redness, thickness and scaling.
0.1% mometasone furoate + 5% salicylic acid ointment is significiantly more effective than 0.05% flucinonide ointment in managing moderate to severe plaque psoriasis. However, although the addition of salicylic acid to treatment with clobetasol propionate is more effective than treatment with a pulsed dye laser alone or treatment with a pulsed dye laser + salicylic acid, a treatment regimen consisting of petrolatum in the morning and 5% coal tar + 3% salicylic acid ointment at night is less effective than treatment with 0.005% calcipotriol twice daily nor does salicylic acid enhance the therapeutic efficacy of dithranol creams when added at a concentration of 2%.
Other psoriasis treatments involving salicylic acid include pulsed dye laser treatment + topical calcipotriol and salicylic acid, as well as the combination of salicylic acid and betamethasone dipropionate.
3.6 Warts treatment
Salicylic acid is an effective treatment for common warts, or verrucca vulgaris. In one study, 26% salicylic acid in a polyacrylic vehicle cleared or greatly improved warts in 81% of patients after just 2 weeks of treatment, while patches containing salicylic acid showed a cure rate of 69% in another study. The application of salicylic acid for 5 days prior to pulsed dye laser therapy also lowered the number of pulsed dye laser therapy sessions required to achieve complete clearance of common warts.
Several salicylic acid-containing treatments have been investigated for managing plantar warts caused by HPV. In a double-blind, controlled study, monochloroacetic acid crystals + 60% salicylic acid ointment was found to be significantly more effective than placebo, curing 66% of patients compared to only 18% in the placebo group. The combination of 5% imiquimod cream and a 40% salicylic acid pad has also been reported to be effective in treating a large plantar wart in one patient.
As early as 1984, a topical preparation of 30% salicylic acid, 5% podophyllin and 1% cantharidin successfully treated plantar warts in 81 out of 100 children over the course of 6 months to a year. This treatment has been shown to be more effective than cryotherapy, another common method widely used for treating plantar warts.
Other salicylic acid-containing treatments for warts that have clinical efficacy include the combination of salicylic and lactic acids and the combination of glycolic and salicylic acids in a gel, which may be a good first-line treatment for facial flat warts.
3.7 Xerosis treatment
Salicylic acid does not influence the water content of healthy skin, but it can help improve abnormally dry skin, a condition known as xerosis. An ointment containing 5% salicylic acid + 10% urea (Kerasal) is as effective as 12% ammonium lactate lotion (Lac-Hydrin) in reducing the severity of foot xerosis, as shown in a double-blind clinical study. This may be related to enhanced desquamation, as urea has been shown to improve the keratolytic effect of salicylic acid.
4. Side Effects
4.1 Skin irritation
Salicylic acid is a skin irritant. Fortunately, its irritation potential can be limited by encapsulation in liposomes and by controlling its penetration into the skin. The surfactant system is particularly important in controlling irritancy, with mild nonionic surfactants like isoceteth-20 keeping the barrier intact while cleansing the skin. Another good strategy is to target more salicylic acid to the epidermis and reduce the rate of salicylic acid permeation through the skin through the use of a polyurethane polymer such as polyolprepolymer-15. Neutralizing salicylic acid with sodium hydroxide to produce sodium salicylate also helps make it suitable for sensitive skin without compromising its antiaging benefits.
4.2 May increase photosensitivity
Although the US FDA advises that all exolifants be used with sun protection due to the concern that repeated use may increase the exposure of the epidermis and dermis to UV radiation, treatment with 2% salicylic acid for 3.5 weeks has been demonstrated not to increase the sensitivity of human skin to solar-simulated radiation, unlike a similar treatment with 10% glycolic acid. The effects of higher concentrations of salicylic acid or longer periods of treatment have not been evaluated, however.
4.3 Salicylate intoxication
Salicylic acid toxicity or salicylism can occur from topical application, though this is rare. Topical products containing 2% salicylic acid pose minimal risk of adverse systemic effects to patients without extensive skin disorders, but salicylic acid can be potentially lethal to infants and young children who accidentally ingest highly concentrated preparations or who are subjected to prolonged topical application of salicylic acid under occulsion. Adults can also suffer from salicylate poisoning, as shown in the case of an 80-year old woman whose mental status was affected after 6 days' treatment with salicylate containing ointments.
Patients with skin disorders such as psoriasis or ichytosis are also at higher risk of salicylate intoxication, as a damaged skin barrier greatly enhances the absorption of topical salicylic acid. Long-term topical administration of salicylic acid on widespread psoriatic lesions can lead to systemic poisoning, including metabolic acidosis, respiratory alkalosis,  as well as reversible inner ear damage and hearing loss.
- Duthie GG, Wood AD. Natural salicylates: foods, functions and disease prevention. Food Funct. (2011)
- Ollerstam O, Larsson S. Salicylic acid mediates resistance in the willow Salix viminalis against the gall midge Dasineura marginemtorquens. J Chem Ecol. (2003)
- Haas LF. Willow. J Neurol Neurosurg Psychiatry. (1996)
- Paterson J, et. al. Is there a role for dietary salicylates in health? Proc Nutr Soc. (2006)
- Harada K, et. al. In-vitro permeability to salicylic acid of human, rodent, and shed snake skin. J Pharm Pharmacol. (1993)
- Takahashi H, et. al. The percutaneous absorption of salicylic acid. J Dermatol. (1976)
- Murakami T, et. al. Effect of ointment bases on topical and transdermal delivery of salicylic acid in rats: evaluation by skin microdialysis. J Pharm Pharmacol. (1998)
- Schwarb FP, et. al. Percutaneous absorption of salicylic acid in man after topical administration of three different formulations. Dermatology. (1999)
- Tsai J, et. al. Distribution of salicylic acid in human stratum corneum following topical application in vivo: a comparison of six different formulations. Int J Pharm. (1999)
- Rehman K, Tan CM, Zulfakar MH. Development and in-vitro characterization of fish oil oleogels containing benzoyl peroxide and salicylic acid as keratolytic agents. Drug Res (Stuttg). (2014)
- Chen T, et. al. Enhanced follicular delivery of salicylic acid in vivo by a novel microgel technology. J Am Acad Dermatol. (2009)
- Padula C, et. al. Combined patch containing salicylic acid and nicotinamide: role of drug interaction. Curr Drug Deliv. (2010)
- Im JS, et. al. Evaluation of salicylic acid fatty ester prodrugs for UV protection. Drug Dev Ind Pharm. (2011)
- Leveque N, et. al. Use of a molecular form technique for the penetration of supersaturated solutions of salicylic acid across silicone membranes and human skin in vitro. Int J Pharm. (2006)
- Murakami T, et. al. Iontophoretic transdermal delivery of salicylic acid dissolved in ethanol-water mixture in rats. Skin Pharmacol Appl Skin Physiol. (1999)
- Singh P, Roberts MS. Iontophoretic transdermal delivery of salicylic acid and lidocaine to local subcutaneous structures. J Pharm Sci. (1993)
- Megwa SA, et. al. Ion-pair formation as a strategy to enhance topical delivery of salicylic acid. J Pharm Pharmacol. (2000)
- Abu Hena Mostofa Kamal M, et. al. Enhanced skin permeation of salicylate by ion-pair formation in non-aqueous vehicle and further enhancement by ethanol and l-menthol. Chem Pharm Bull (Tokyo). (2006)
- Rhein L, et. al. Targeted delivery of salicylic acid from acne treatment products into and through skin: role of solution and ingredient properties and relationships to irritation. J Cosmet Sci. (2004)
- Combrinck J, Otto A, du Plessis J. Whey Protein/Polysaccharide-Stabilized Emulsions: Effect of Polymer Type and pH on Release and Topical Delivery of Salicylic Acid. AAPS PharmSciTech. (2014)
- Shen WW, Danti AG, Bruscato FN. Effect of nonionic surfactants on percutaneous absorption of salicylic acid and sodium salicylate in the presence of dimethyl sulfoxide. J Pharm Sci. (1976)
- Golden GM, McKie JE, Potts RO. Role of stratum corneum lipid fluidity in transdermal drug flux. J Pharm Sci. (1987)
- Benfeldt E, Serup J, Menné T. Effect of barrier perturbation on cutaneous salicylic acid penetration in human skin: in vivo pharmacokinetics using microdialysis and non-invasive quantification of barrier function. Br J Dermatol. (1999)
- Taylor JR, Halprin KM. Percutaneous absorption of salicylic acid. Arch Dermatol. (1975)
- Roberts MS, Harlock E. Effect of repeated skin application on percutaneous absorption of salicylic acid. J Pharm Sci. (1978)
- Fung W, et. al. Relative bioavailability of salicylic acid following dermal application of a 30% salicylic acid skin peel preparation. J Pharm Sci. (2008)
- Davis DA, et. al. Percutaneous absorption of salicylic acid after repeated (14-day) in vivo administration to normal, acnegenic or aged human skin. J Pharm Sci. (1997)
- Merinville E, et. al. Exfoliation for sensitive skin with neutralized salicylic acid? International Journal of Cosmetic Science. (2009)
- Kligman D, Kligman AM. Salicylic acid peels for the treatment of photoaging. Dermatol Surg. (1998)
- Swinehart JM. Salicylic acid ointment peeling of the hands and forearms. Effective nonsurgical removal of pigmented lesions and actinic damage. J Dermatol Surg Oncol. (1992)
- Dahl A, Yatskayer M, Raab S, Oresajo C. Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone. J Drugs Dermatol. (2013)
- Draelos ZD, et. al. Dyspigmentation, skin physiology, and a novel approach to skin lightening. J Cosmet Dermatol. (2013)
- Merinville E, et. al. Three clinical studies showing the anti-aging benefits of sodium salicylate in human skin. J Cosmet Dermatol. (2010)
- Schlaak M, Simon JC. Topical treatment of actinic keratoses with low-dose 5-fluorouracil in combination with salicylic acid--pilot study. J Dtsch Dermatol Ges. (2010)
- Stockfleth E, et. al. Low-dose 5-fluorouracil in combination with salicylic acid as a new lesion-directed option to treat topically actinic keratoses: histological and clinical study results. Br J Dermatol. (2011)
- Stockfleth E, Zwingers T, Willers C. Recurrence rates and patient assessed outcomes of 0.5% 5-fluorouracil in combination with salicylic acid treating actinic keratoses. Eur J Dermatol. (2012)
- Gladstone HB, et. al. Efficacy of hydroquinone cream (USP 4%) used alone or in combination with salicylic acid peels in improving photodamage on the neck and upper chest. Dermatol Surg. (2000)
- Isoda M, et. al. New formulation of chemical peeling agent: histological evaluation in sun-damaged skin model in hairless mice. J Dermatol Sci. (2001)
- Birgin B, et. al. Effects of topical petrolatum and salicylic acid upon skin photoreaction to UVA. Eur J Dermatol. (2005)
- Fetil E, et. al. Effects of topical petrolatum and salicylic acid on the erythemogenicity of UVB. Eur J Dermatol. (2002)
- Sams RL 2nd, et. al. Effects of alpha- and beta-hydroxy acids on the edemal response induced in female SKH-1 mice by simulated solar light. Toxicol Appl Pharmacol. (2002)
- Mammone T, et. al. Salicylic acid protects the skin from UV damage. J Cosmet Sci. (2006)
- Dainichi T, et. al. Chemical peeling by SA-PEG remodels photo-damaged skin: suppressing p53 expression and normalizing keratinocyte differentiation. J Invest Dermatol. (2006)
- Dainichi T, et. al. Chemical peeling with salicylic acid in polyethylene glycol vehicle suppresses skin tumour development in hairless mice. Br J Dermatol. (2003)
- National Toxicology Program. Photocarcinogenesis study of glycolic acid and salicylic acid (CAS Nos. 79-14-1 and 69-72-7) in SKH-1 mice (simulated solar light and topical application study). Natl Toxicol Program Tech Rep Ser. (2007)
- Abdel-Daim M, et. al. Effect of chemical peeling on photocarcinogenesis. J Dermatol. (2010)
- Kornhauser A, et. al. The effects of topically applied glycolic acid and salicylic acid on ultraviolet radiation-induced erythema, DNA damage and sunburn cell formation in human skin. J Dermatol Sci. (2009)
- Fabbrocini G, et. al. Salicylic acid for the treatment of melasma: new acquisitions for monitoring the clinical improvement. Skin Res Technol. (2013)
- Ejaz A, et. al. Comparison of 30% salicylic acid with Jessner's solution for superficial chemical peeling in epidermal melasma. J Coll Physicians Surg Pak. (2008)
- Grimes PE. The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups. Dermatol Surg. (1999)
- Kodali S, et. al. A prospective, randomized, split-face, controlled trial of salicylic acid peels in the treatment of melasma in Latin American women. J Am Acad Dermatol. (2010)
- Bashir SJ, et. al. Cutaneous bioassay of salicylic acid as a keratolytic. Int J Pharm. (2005)
- Bae BG, et. al. Salicylic acid peels versus Jessner's solution for acne vulgaris: a comparative study. Dermatol Surg. (2013)
- Hartmann AA. The influence of various factors on the human resident skin flora. Semin Dermatol. (1990)
- Zander E, Weisman S. Treatment of acne vulgaris with salicylic acid pads. Clin Ther. (1992)
- Lee HS, Kim IH. Salicylic acid peels for the treatment of acne vulgaris in Asian patients. Dermatol Surg. (2003)
- Hashimoto Y, et. al. Salicylic acid peels in polyethylene glycol vehicle for the treatment of comedogenic acne in Japanese patients. Dermatol Surg. (2008)
- Dainichi T, et. al. Excellent clinical results with a new preparation for chemical peeling in acne: 30% salicylic acid in polyethylene glycol vehicle. Dermatol Surg. (2008)
- Joshi SS, et. al. Effectiveness, safety, and effect on quality of life of topical salicylic acid peels for treatment of postinflammatory hyperpigmentation in dark skin. Dermatol Surg. (2009)
- Ahn HH, Kim IH. Whitening effect of salicylic acid peels in Asian patients. Dermatol Surg. (2006)
- Moy RL, et. al. Single-center, open-label study of a proprietary topical 0.5% salicylic acid-based treatment regimen containing sandalwood oil in adolescents and adults with mild to moderate acne. J Drugs Dermatol. (2012)
- Zheng Y, et. al. Clinical evidence on the efficacy and safety of an antioxidant optimized 1.5% salicylic acid (SA) cream in the treatment of facial acne: an open, baseline-controlled clinical study. Skin Res Technol. (2013)
- Shalita AR. Comparison of a salicylic acid cleanser and a benzoyl peroxide wash in the treatment of acne vulgaris. Clin Ther. (1989)
- Boutli F, et. al. Comparison of chloroxylenol 0.5% plus salicylic acid 2% cream and benzoyl peroxide 5% gel in the treatment of acne vulgaris: a randomized double-blind study. Drugs Exp Clin Res. (2003)
- NilFroushzadeh MA, et. al. Clindamycin lotion alone versus combination lotion of clindamycin phosphate plus tretinoin versus combination lotion of clindamycin phosphate plus salicylic acid in the topical treatment of mild to moderate acne vulgaris: a randomized control trial. Indian J Dermatol Venereol Leprol. (2009)
- Seidler EM, Kimball AB. Meta-analysis comparing efficacy of benzoyl peroxide, clindamycin, benzoyl peroxide with salicylic acid, and combination benzoyl peroxide/clindamycin in acne. J Am Acad Dermatol. (2010)
- Akarsu S, et. al. Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris. J Dermatol. (2012)
- Babayeva L, et. al. Comparison of tretinoin 0.05% cream and 3% alcohol-based salicylic acid preparation in the treatment of acne vulgaris. J Eur Acad Dermatol Venereol. (2011)
- Marczyk B, et. al. Comparative study of the effect of 50% pyruvic and 30% salicylic peels on the skin lipid film in patients with acne vulgaris. J Cosmet Dermatol. (2014)
- Garg VK, Sinha S, Sarkar R. Glycolic acid peels versus salicylic-mandelic acid peels in active acne vulgaris and post-acne scarring and hyperpigmentation: a comparative study. Dermatol Surg. (2009)
- Levesque A, et. al. Randomized trial comparing a chemical peel containing a lipophilic hydroxy acid derivative of salicylic acid with a salicylic acid peel in subjects with comedonal acne. J Cosmet Dermatol. (2011)
- Kar BR, Tripathy S, Panda M. Comparative study of oral isotretinoin versus oral isotretinoin + 20% salicylic Acid peel in the treatment of active acne. J Cutan Aesthet Surg. (2013)
- Going SM, et. al. Salicylic acid gel for scalp psoriasis. Clin Exp Dermatol. (1986)
- Kircik L. Salicylic Acid 6% in an ammonium lactate emollient foam vehicle in the treatment of mild-to-moderate scalp psoriasis. J Drugs Dermatol. (2011)
- Mason AR, et. al. Topical treatments for chronic plaque psoriasis. Cochrane Database Syst Rev. (2013)
- Medansky RS, Cuffie CA, Tanner DJ. Mometasone furoate 0.1%-salicylic acid 5% ointment twice daily versus fluocinonide 0.05% ointment twice daily in the management of patients with psoriasis. Clin Ther. (1997)
- Koo J, et. al. Mometasone furoate 0.1%-salicylic acid 5% ointment versus mometasone furoate 0.1% ointment in the treatment of moderate-to-severe psoriasis: a multicenter study. Clin Ther. (1998)
- Ilknur T, et. al. Comparison of the effects of pulsed dye laser, pulsed dye laser + salicylic acid, and clobetasole propionate + salicylic acid on psoriatic plaques. Dermatol Surg. (2006)
- Singh P, et. al. Comparative evaluation of topical calcipotriol versus coal tar and salicylic acid ointment in chronic plaque psoriasis. J Drugs Dermatol. (2013)
- de Mare S, et. al. The relevance of salicylic acid in the treatment of plaque psoriasis with dithranol creams. Skin Pharmacol. (1988)
- de Leeuw J, et. al. Concomitant treatment of psoriasis of the hands and feet with pulsed dye laser and topical calcipotriol, salicylic acid, or both: a prospective open study in 41 patients. J Am Acad Dermatol. (2006)
- Gip L, Hamfelt A. Percutaneous absorption of betamethasone-17, 21-dipropionate and salicylic acid during the treatment of psoriasis and eczema. J Int Med Res. (1976)
- Baboota S, et. al. Nanocarrier-based hydrogel of betamethasone dipropionate and salicylic acid for treatment of psoriasis. Int J Pharm Investig. (2011)
- Parish LC, Monroe E, Rex IH Jr. Treatment of common warts with high-potency (26%) salicylic acid. Clin Ther. (1988)
- Bart BJ, et. al. Salicylic acid in karaya gum patch as a treatment for verruca vulgaris. J Am Acad Dermatol. (1989)
- Akarsu S, et. al. Verruca vulgaris: pulsed dye laser therapy compared with salicylic acid + pulsed dye laser therapy. J Eur Acad Dermatol Venereol. (2006)
- Steele K, et. al. Monochloroacetic acid and 60% salicylic acid as a treatment for simple plantar warts: effectiveness and mode of action. Br J Dermatol. (1988)
- Tucker SB, Ali A, Ransdell BL. Plantar wart treatment with combination imiquimod and salicylic acid pads. J Drugs Dermatol. (2003)
- Coskey RJ. Treatment of plantar warts in children with a salicylic acid-podophyllin-cantharidin product. Pediatr Dermatol. (1984)
- Kaçar N, et. al. Cantharidin-podophylotoxin-salicylic acid versus cryotherapy in the treatment of plantar warts: a randomized prospective study. J Eur Acad Dermatol Venereol. (2012)
- Cockayne ES; EVERT Trial Team. The EVERT (effective verruca treatments) trial protocol: a randomised controlled trial to evaluate cryotherapy versus salicylic acid for the treatment of verrucae. Trials. (2010)
- Bruggink SC, et. al. Cryotherapy with liquid nitrogen versus topical salicylic acid application for cutaneous warts in primary care: randomized controlled trial. CMAJ. (2010)
- Cockayne S, et. al. Cryotherapy versus salicylic acid for the treatment of plantar warts (verrucae): a randomised controlled trial. BMJ. (2011)
- Khattar JA, et. al. Topical zinc oxide vs. salicylic acid-lactic acid combination in the treatment of warts. Int J Dermatol. (2007)
- Rodríguez-Cerdeira C, Sánchez-Blanco E. Glycolic acid 15% plus salicylic acid 2%: a new therapeutic pearl for facial flat warts. J Clin Aesthet Dermatol. (2011)
- Rácz I, Soós G, Jakab E. Water content of the skin following salicylic acid and urea treatment. Hautarzt. (1989)
- Jennings MB, et. al. Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study. J Am Podiatr Med Assoc. (1998)
- Gabard B, Bieli E. Salicylic acid and urea--possible modification of the keratolytic effect of salicylic acid by urea. Hautarzt. (1989)
- Bhalerao SS, Raje Harshal A. Preparation, optimization, characterization, and stability studies of salicylic acid liposomes. Drug Dev Ind Pharm. (2003)
- Cosmetic Ingredient Review Expert Panel. Safety assessment of Salicylic Acid, Butyloctyl Salicylate, Calcium Salicylate, C12-15 Alkyl Salicylate, Capryloyl Salicylic Acid, Hexyldodecyl Salicylate, Isocetyl Salicylate, Isodecyl Salicylate, Magnesium Salicylate, MEA-Salicylate, Ethylhexyl Salicylate, Potassium Salicylate, Methyl Salicylate, Myristyl Salicylate, Sodium Salicylate, TEA-Salicylate, and Tridecyl Salicylate. Int J Toxicol. (2003)
- Madan RK, Levitt J. A review of toxicity from topical salicylic acid preparations. J Am Acad Dermatol. (2014)
- Brubacher JR, Hoffman RS. Salicylism from topical salicylates: review of the literature. J Toxicol Clin Toxicol. (1996)
- Reingardiene D, Lazauskas R. Acute salicylate poisoning. Medicina (Kaunas). (2006)
- Oualha M, et. al. Local salicylate transcutaneous absorption: an unrecognized risk of severe intoxication: a case report. Arch Pediatr. (2012)
- Pertoldi F, D'Orlando L, Mercante WP. Acute salicylate intoxication after trancutaneous absorption. Minerva Anestesiol. (1999)
- Chodorowski Z, Anand JS, Waldman W. Suicidal salicylate intoxications and unintentional percutaneous poisoning with salicylic ointment. Przegl Lek. (2003)
- Luderschmidt C, Plewig G. Chronic percutaneous salicylic acid poisoning. Hautarzt. (1975)
- Jongevos SF, et. al. Acute perceptive hearing loss and metabolic acidosis as complications of the topical treatment of psoriasis with salicylic acid-containing ointment. Ned Tijdschr Geneeskd. (1997)
- Maune S, et. al. Toxic inner ear damage in topical treatment of psoriasis with salicylates. Laryngorhinootologie. (1997)
- Pstragowska W. Poisoning with salicylate ointment in an 8-year-old girl with congenital ichthyosis. Pediatr Pol. (1971)
- Abdel-Magid EH, el-Awad Ahmed FR. Salicylate intoxication in an infant with ichthyosis transmitted through skin ointment--a case report. Pediatrics. (1994)
- Davies MG, Briffa DV, Greaves MW. Systemic toxicity from topically applied salicylic acid. Br Med J. (1979)
- Chiaretti A, et. al. Salicylate intoxication using a skin ointment. Acta Paediatr. (1997)