Avène Anti-wrinkle Concentrate

The Anti-wrinkle Concentrate seems to works well with Avène Eluage Cream, reducing wrinkles in many areas of the face, as well as improving skin hydration, colour, elasticity and the evenness of the complexion.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

D

Wrinkle treatment

Moderate

Crow's feet, nasolabial folds and wrinkles on the forehead, glabellas and around the mouth all improved by between 14% to 34%.

D

Skin lightening

Moderate

Complexion evenness increased by 38% after 90 days of treatment.

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Ingredients


Water (Aqua), Cetearyl Alcohol, Thermal Spring Water (Aqua), Cetyl Esters, Caprylic/Capric Triglyceride, Ceteareth-20, Glycol Montanate, Cyclomethicone, Ceteareth-33, Sodium Hyaluronate, Acrylates Copolymer, BHT, Butylparaben, Carbomer, Ethylparaben, Fragrance (Parfum), Isobutylparaben, Methylparaben, Phenoxyethanol, Polymethyl Methacrylate, Propylparaben, Red 33 (CI 17200), Retinal, Triethanolamine.
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
CETEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 1 (SEE SOURCES) ALLOWED (SOURCE)
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
CETYL ESTERS (EMOLLIENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
CAPRYLIC/CAPRIC TRIGLYCERIDE (EMOLLIENT, MASKING, PERFUMING, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
CETEARETH-20 (CLEANSING, EMULSIFYING, SURFACTANT) 2 (SEE SOURCES) 3 (SEE SOURCES) ALLOWED (SOURCE)
GLYCOL MONTANATE (EMULSIFYING, OPACIFYING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
CYCLOMETHICONE (ANTISTATIC, EMOLLIENT, HAIR CONDITIONING, HUMECTANT, SOLVENT, VISCOSITY CONTROLLING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CETEARETH-33 (CLEANSING, EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM HYALURONATE (HUMECTANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ACRYLATES COPOLYMER (ANTISTATIC, BINDING, FILM FORMING) NO DATA NO DATA ALLOWED (SOURCE)
BHT (ANTIOXIDANT, MASKING) NO DATA NO DATA ALLOWED (SOURCE)
BUTYLPARABEN (MASKING, PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
CARBOMER (EMULSION STABILISING, GEL FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
ETHYLPARABEN (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
FRAGRANCE (PERFUMING) NO DATA NO DATA NO DATA
ISOBUTYLPARABEN (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PHENOXYETHANOL (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
POLYMETHYL METHACRYLATE (FILM FORMING) NO DATA NO DATA ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CI 17200 (COSMETIC COLORANT) NO DATA NO DATA ALLOWED (SOURCE)
RETINAL (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
TRIETHANOLAMINE (BUFFERING, EMULSIFYING, MASKING, SURFACTANT) 2 (SEE SOURCES) 0 (SEE SOURCES) RESTRICTED (SOURCE)

Clinical Studies


Retinaldehyde/hyaluronic acid fragments: a synergistic association for the management of skin aging.

Products

Avène Eluage Cream

Avène Eluage Anti-wrinkle Concentrate

Trial Design

Open-label, multi-center, uncontrolled

Duration

3 months of treatment

Subjects

1462 men and women mainly of Fitzpatrick phototypes II and III, aged above 45 years, presenting facial areas with clinical signs of skin aging such as loss of firmness, furrows, wrinkles, fine lines and pigmentary changes.

Regimen

Group 1: Applied moisturizer in the morning and Avène Eluage Cream to the face and neck in the evening.

Group 2: Applied moisturizer in the morning and Avène Eluage Anti-wrinkle Concentrate on areas with deep wrinkles/furrows in the evening.

Group 3: Applied moisturizer in the morning and both products (cream before concentrate) in the evening.

Methods of Assessment

Overall photoaging: Larnier's scale, a 6-point photographic scale in which each grade is depicted by standardized photographs of 3 representative patients.

Clinical signs of aging: Evaluated by dermatologists using a 4-point scale.

Wrinkles: Optical profilometry on silicone skin replicas and digital analysis of resulting skin surface images.

Complexion evenness: Assessed by dermatologists using a 10-point visual analogue scale.

Side Effects

Not documented, but 96-98% of subjects found the products to be well- or very well-tolerated.

Conflicts of Interest

1 out of the 9 authors was an employee of Laboratoires Dermatologiques Avène.

Effects observed in this study:

The overall severity of photoaging declined by 15-19% after 90 days in all 3 groups. The anti-wrinkle concentrate led to crow's feet, nasolabial folds and wrinkles on the forehead, glabellas and around the mouth becoming less visible. Analysis of the crow's feet replicas showed significant decreases in skin roughness and wrinkle depth in subjects who used both products.

In Groups 1 and 3, skin dryness decreased by 62-65%, hyperpigmentation by 31-34%, and ptosis of the face oval by 18-22% post-treatment, while the elasticity of the skin improved by 32-33%. The evenness of the complexion improved by 33-38% in subjects using either product, which increased to 53% in subjects using both products.