Avène Thermal Spring Water

Avène Thermal Spring Water is useful as adjunctive care for reducing inflammation and discomfort after aggressive dermatology procedures such as laser resurfacing or photodynamic therapy.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Healing

Strong

Reduces the side effects and discomfort experienced by patients after laser and photodynamic treatments.

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Ingredients


Thermal Spring Water (Aqua)
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)

Clinical Studies


Beneficial effects of spraying low mineral content thermal spring water after fractional photothermolysis in patients with dermal melasma.

Products

Avène Thermal Spring Water

Avène Creme pour Peaux Intolerantes (cream for intolerant skin)

Trial Design

Split-face, comparative

Duration

2 days of treatment

Subjects

28 patients with bilateral dermal melasma

Regimen

After laser treatment, Avène Thermal Spring Water was sprayed at a rate of 10 sprays per minute for 10 minutes. After removing excess water at the surface the moisturizing cream (Avène Creme pour Peaux Intolerantes) was applied.

For the next 2 days, patients applied only the moisturizing cream on one side of the face, and applied both the cream and Avène Thermal Spring Water on the other side, at least 6 times a day.

Patients also avoided sun exposure and used sun protection.

Methods of Assessment

Patients' self-assessments of side effects (stinging, pain, skin dryness, swelling and redness) using the Visual Analogue Scale.

Investigator's ratings of purpura, skin dryness, swelling and scars using a Visual Analogue Scale and measurements of erythema and hyperpigmentation using a dermaspectrometer.

Side Effects

None reported

Conflicts of Interest

1 out of 3 authors was an employee of Laboratoires Dermatologiques Avène.

Effects observed in this study:

Fractional laser thermolysis causes acute skin discomfort in the minutes after the procedure, as the laser energy accumulates in the skin. Spraying Avène Thermal Spring Water significantly decreased the short-term adverse effects associated with this procedure, such as pain, dryness and redness.

Comparative benefit of two thermal spring waters after photodynamic therapy procedure.

Products

Avène Thermal Spring Water

Comparative spring water spray

Trial Design

Double-blind, comparative

Duration

1 week of treatment

Subjects

25 patients of Fitzpatrick phototypes I, II or III, undertaking 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for actinic keratosis or moderate to severe acne.

Regimen

After completing the ALA-PDT treatment sessions, patients used either the Avène Thermal Spring Water or a high mineral content spring water at least 4 times a day. The water was sprayed onto the full face for 10 seconds and left on the skin for 30 seconds before gently patting dry.

Methods of Assessment

Investigator evaluations of stinging, pain, tightening, pruritus and erythema on a 4-point scale.

Digital photographs taken with the Visia Complexion Analysis system.

Side Effects

No adverse effects were noted.

Conflicts of Interest

2 out of 3 authors were employees of Laboratoires Dermatologiques Avène.

Effects observed in this study:

Like the high mineral content water, Avène Thermal Spring Water significantly reduced the severity of stinging and erythema. It was more effective than the high mineral content water in reducing tightening, pain and itching.

All patients in the Avène Thermal Spring Water group considered it to be effective or very effective, compared to 81% of the patients treated with the high mineral content water spray.

Efficacy and safety of a topically applied Avène spring water spray in the healing of facial skin after laser resurfacing.

Products

Avène Thermal Spring Water

Petrolatum ointment

Avène Extra Gentle Cleanser

Avène Couvrance Cream SPF 20

Trial Design

Randomized, open-label, multicenter, parallel-group, controlled

Duration

84 days of treatment

Subjects

74 men and women undertaking carbon dioxide pulsed laser therapy on the face.

Regimen

Water group: Immediately after the laser session, sprayed Avène Thermal Spring Water, then applied petrolatum ointment on facial areas where laser treatment had been performed, for 28 days. Also given Avène Extra Gentle Cleanser to cleanse the irritated skin, and a Avène Couvrance Cream SPF 20 as a sunblock covering cream for outdoor and social activities.

Control group: Same as the water group, but only applied the petrolatum ointment.

Methods of Assessment

Investigator assessments of efficacy, severity of erythema, pain, itching, stinging and tightening on a 4-point scale

Patient ratings of efficacy, tolerance and ease of use on a 4-point scale

Side Effects

1 patient in the water group experienced allergic contact dermatitis, while 2 patients in the control group had pustules around the lips and contact allergy caused by the cleanser.

Conflicts of Interest

2 out of 8 authors were employees of Laboratoires Pierre Fabre, which markets the Avène products.

Effects observed in this study:

Erythema often occurs on the face after laser therapy, and may last up to 3 months. Spraying of Avène Thermal Spring Water in addition to topical application of an emollient, however, reduced the severity of the erythema significantly. It also alleviated itching, stinging and tightening of the skin, but not pain.