Bionect Cream

Bionect Cream, a formulation containing 0.2% sodium hyaluronate, appears to be effective in reducing the signs and symptoms of rosacea even over a short treatment period of 4 weeks.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

D

Rosacea treatment

Strong

Led to marked improvements in papules, erythema, burning/stinging and skin dryness.

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Ingredients


Sodium Hyaluronate, PEG-8 Stearate, Decyl Oleate, Cetearyl Alcohol, Polysorbate 60, Glycerol, Sorbitol (70%), Sodium Dehydroacetate, Methylparaben, Propylparaben, Fragrance, Water
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
SODIUM HYALURONATE (HUMECTANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PEG-8 STEARATE (EMULSIFYING, HUMECTANT, SURFACTANT) 3 (SEE SOURCES) 1 (SEE SOURCES) ALLOWED (SOURCE)
DECYL OLEATE (EMOLLIENT, SKIN CONDITIONING) 3 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CETEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 1 (SEE SOURCES) ALLOWED (SOURCE)
POLYSORBATE 60 (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SORBITOL (HUMECTANT, PLASTICISER, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SODIUM DEHYDROACETATE (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
FRAGRANCE (PERFUMING) NO DATA NO DATA NO DATA
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)

Clinical Studies


Efficacy and tolerability of low molecular weight hyaluronic acid sodium salt 0.2% cream in rosacea.

Products

Bionect Cream

Cetaphil Gentle Cleanser

Trial Design

Prospective, observational, unblinded, uncontrolled

Duration

4 weeks of treatment, and another 4 weeks where treatment was stopped but subjects continued the cleansing regimen.

Subjects

Healthy males and females with mild to moderate rosacea

Regimen

After cleansing with Cetaphil Gentle Cleanser, participants gently massaged a thin layer of Bionect Cream to the whole face twice daily in the morning and evening for 4 weeks. Thereafter, participants stopped applying Bionect Cream but continued the cleansing regimen for another 4 weeks.

Methods of Assessment

Clinical evaluations of papules, erythema, burning/stinging and dryness on a 5-point scale

Side Effects

No adverse events were experienced

Conflicts of Interest

1 of the 2 authors served as a consultant for Innocutis Holdings, the company that markets Bionect Cream.

Effects observed in this study:

After 4 weeks, papules, erythema, burning/stinging and dryness were improved by 47%, 52%, 68% and 79% respectively, and continued to improve even after treatment was discontinued for 4 weeks.