Bionect Hydrogel

Bionect Hydrogel appears to be useful for treating facial seborrheic dermatitis, but additional blinded studies with a larger number of subjects are needed to delineate its efficacy and safety.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

D

Dermatitis treatment

Moderate

Improved scaling, erythema and pruritus by more than 50% after only 4 weeks of treatment.

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Ingredients


Sodium Hyaluronate, Sorbitol (70%), Sodium Dehydroacetate, Methylparaben, Propylparaben, Carbomer, Sodium Hydroxide, Water
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
SODIUM HYALURONATE (HUMECTANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SORBITOL (HUMECTANT, PLASTICISER, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SODIUM DEHYDROACETATE (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CARBOMER (EMULSION STABILISING, GEL FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM HYDROXIDE (BUFFERING, DENATURANT) NO DATA NO DATA RESTRICTED (SOURCE)
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)

Clinical Studies


Efficacy and safety of a low-molecular weight hyaluronic Acid topical gel in the treatment of facial seborrheic dermatitis.

Products

Bionect Hydrogel

Cetaphil Gentle Cleanser

Trial Design

Prospective, observational, unblinded, single-site

Duration

4 weeks of treatment, followed by 4 weeks where treatment was stopped but the cleansing regimen continued

Subjects

7 subjects with facial seborrheic dermatitis

Regimen

First 4 weeks: Cleansed the affected areas with Cetaphil Gentle Cleanser and patted dry with a soft towel before massaging a thin layer of Bionect Hydrogel onto the affected areas, twice daily, in the morning and evening.

Next 4 weeks: Discontinued the use of Bionect Hydrogel but continued the cleansing regimen.

Methods of Assessment

Clinical evaluation of scaling, erythema, pruritus (itching) and provider global assessment, on a 4-point scale.

Patients' opinions regarding the effectiveness of the treatment.

Side Effects

No adverse events were reported

Conflicts of Interest

Study is sponsored by Innocutis, the company that markets Bionect Hydrogel.

Effects observed in this study:

The mean reductions in scaling, erythema and pruritus were 66.7%, 50% and 60% respectively after 4 weeks of treatment, and remained the same or continued to improve in the majority of the patients after treatment was stopped. The Provider Global Assessment improved by 47.6% by the end of the first 4 weeks, and had improved by 79.2% by the end of the eighth week. Subjects also agreed that Bionect Hydrogel was effective in treating their seborrheic dermatitis.