C'ensil

C'ensil contains a high concentration of ascorbic acid, which is known for its effect in lightening skin. It may be effective in treating skin affected by melasma.

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Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

D

Skin lightening

Mild

Whitens both melasma-affected and unaffected areas of the skin.

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Ingredients


Ascorbic Acid, Penetration Enhancer
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
ASCORBIC ACID (ANTIOXIDANT, BUFFERING, MASKING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PENETRATION ENHANCER NO RECORDS FOUND

Clinical Studies


Clinical efficacy of 25% L-ascorbic acid (C'ensil) in the treatment of melasma.

Products

C'ensil

Trial Design

Open-label, uncontrolled

Duration

16 weeks of treatment

Subjects

39 women between 26-52 years old, of Fitzpatric phototypes III or IV, and with mild to severe melasma.

Regimen

C'ensil serum applied twice daily to the entire face for 16 weeks.

Methods of Assessment

Melasma Area and Severity Index (MASI) score

Mexameter score

Side Effects

Most subjects experienced stinging and a burning sensation, while a few had itching, redness of the skin, and peeling. All side effects were mild and transient, disappearing within 2 weeks.

Conflicts of Interest

None declared.

Effects observed in this study:

Lightening effect: MASI values had decreased significantly at the end of 16 weeks. Mexameter results also showed a significant drop in the degree of pigmentation at the treated sites, except on the forearm. Moreover, the mexameter scores of the areas unaffected by melasma were also significantly lower, implying that the C'ensil serum has a whitening effect on all areas of the skin, not just those affected by melasma.