Cetaphil DermaControl Moisturizer

Cetaphil's DermaControl Moisturizer is specially formulated for acne-prone and acne-affected skin. It controls skin sebum levels and thus helps reduce facial shine, and helps diminish the irritation caused by topical retinoids such as tretinoin.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Acne treatment

Mild

Alleviates the local side effects of acne treatment with tretinoin cream.

D

Less oiliness

Mild

Reduces surface sebum levels and facial shine on the forehead and cheeks, hence giving the appearance of less oily skin.

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Ingredients


Avobenzone 3%, Octisalate (5%), Octocrylene (7%). , Water, Isopropyl Lauroyl Sarcosinate, Glycerin, Dimethicone, Diisopropyl Sebacate, Silica, Polymethyl Methacrylate, Aluminum Starch Octenylsuccinate, Sucrose Tristearate, Dimethiconol, Pentylene Glycol, Polysorbate 61, Sodium Stearoyl Glutamate, Phenoxyethanol, Caprylyl Glycol, Tocopheryl Acetate, Glycyrrhetinic Acid, Panthenol, Triethanolamine, Allantoin, Carbomer, Potassium Sorbate, Zinc Gluconate, Xanthan Gum, Disodium EDTA, Hydroxypalmitoyl Sphinganine
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
BUTYL METHOXYDIBENZOYLMETHANE (UV ABSORBER, UV FILTER) NO DATA NO DATA ALLOWED (SOURCE)
ETHYLHEXYL SALICYLATE (UV ABSORBER, UV FILTER) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
OCTOCRYLENE (UV ABSORBER, UV FILTER) NO DATA NO DATA ALLOWED (SOURCE)
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
ISOPROPYL LAUROYL SARCOSINATE (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DIISOPROPYL SEBACATE (EMOLLIENT, PLASTICISER, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
SILICA (ABRASIVE, ABSORBENT, ANTICAKING, BULKING, OPACIFYING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
POLYMETHYL METHACRYLATE (FILM FORMING) NO DATA NO DATA ALLOWED (SOURCE)
ALUMINUM STARCH OCTENYLSUCCINATE (ABSORBENT, ANTICAKING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
SUCROSE TRISTEARATE (EMOLLIENT, EMULSIFYING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONOL (ANTIFOAMING, EMOLLIENT, MOISTURISING) NO DATA NO DATA ALLOWED (SOURCE)
PENTYLENE GLYCOL (SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
POLYSORBATE 61 (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM STEAROYL GLUTAMATE (CLEANSING, EMULSIFYING, HAIR CONDITIONING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PHENOXYETHANOL (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
CAPRYLYL GLYCOL (EMOLLIENT, HAIR CONDITIONING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
TOCOPHERYL ACETATE (ANTIOXIDANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
GLYCYRRHETINIC ACID (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PANTHENOL (ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
TRIETHANOLAMINE (BUFFERING, EMULSIFYING, MASKING, SURFACTANT) 2 (SEE SOURCES) 0 (SEE SOURCES) RESTRICTED (SOURCE)
ALLANTOIN (SKIN CONDITIONING, SKIN PROTECTING, SOOTHING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CARBOMER (EMULSION STABILISING, GEL FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
POTASSIUM SORBATE (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
ZINC GLUCONATE (DEODORANT, SKIN CONDITIONING) NO DATA NO DATA RESTRICTED (SOURCE)
XANTHAN GUM (BINDING, EMULSIFYING, EMULSION STABILISING, GEL FORMING, SKIN CONDITIONING, SURFACTANT, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
HYDROXYPALMITOYL SPHINGANINE (HAIR CONDITIONING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)

Clinical Studies


The Role of Skin Care as an Integral Component in the Management of Acne Vulgaris: Part 2: Tolerability and Performance of a Designated Skin Care Regimen Using a Foam Wash and Moisturizer SPF 30 in Patients with Acne Vulgaris Undergoing Active Treatment.

Products

Cetaphil DermaControl Foam Wash

Cetaphil DermaControl Moisturizer

Trial Design

Open-label, single-center

Duration

28 days of treatment

Subjects

91 men and women between the ages of 12 and 45 years, with currently active acne vulgaris and who had been undergoing their current treatment for at least a month

Regimen

Subjects used the Foam Wash twice daily in the morning and evening, and the Moisturizer once daily in the morning after cleansing

Methods of Assessment

Subjects' reporting of facial skin symptoms over the course of the study, specifically itching, burning, stinging, and skin tightness

Objective assessments of erythema, edema, dryness and roughness by the investigator

Comparison of facial photographs taken by the VISIA CR system at baseline and at each follow-up visit

Measurements of transepidermal water loss using a Tewameter 300

Measurements of skin hydration through corneometry using the NOVA DPM 9003

Cosmetic acceptability questionnaire

Side Effects

See effects observed in this study

Conflicts of Interest

1 of the 2 authors was the Medical Science Lead at Galderma Laboratories, and the other received compensation from Galderma for his participation in the study.

Effects observed in this study:

Neither the subjective nor objective assessments discerned any significant differences in their measured parameters (stinging, tightness, itching, burning, erythema, edema and roughness) at any time point during the study. The mean score for facial skin dryness did, however, have a small but significant increase at Days 14 and 28 compared to baseline.

Instrumental measurements revealed that TEWL had decreased significantly by 7.8% compared to baseline by Day 28. Epidermal hydration was slightly increased (5.7%), but not statistically significantly.

The majority of the subjects felt that the Cetaphil DermaControl Foam Wash and Moisturizer were easily incorporated into their daily skin routine and non-irritating. They also liked the texture of the products, and would recommend them to family and friends. In addition, >85% believed that the moisturizer had helped improve the facial skin tolerability of the medications they were using for acne treatment.

Adjunctive use of a facial moisturizer SPF 30 containing ceramide precursor improves tolerability of topical tretinoin 0.05%: a randomized, investigator-blinded, split-face study.

Products

Cetaphil DermaControl Moisturizer

Retin-A

Cetaphil Gentle Skin Cleanser

Trial Design

Randomized, investigator-blind, split-face, controlled, single-center

Duration

4 weeks of treatment

Subjects

34 men and women aged at least 18 years, with healthy skin of Fitzpatrick skin type I, II, III or IV

Regimen

Subjects applied Retin-A once daily to the whole face in the evening 30 minutes after cleansing, and Cetaphil DermaControl Moisturizer once daily in the morning to one side of the face

Methods of Assessment

Assessments of erythema, scaling, dryness, stinging/burning and pruritus on a 4-point scale

Corneometry measurements of skin hydration

Cosmetic acceptability questionnaire

Side Effects

See effects observed in this study

Conflicts of Interest

2 of the authors were employees of Galderma, and the third received investigator fees for the study.

Effects observed in this study:

Adjunctive application of Cetaphil DermaControl Moisturizer increased the local tolerability of Retin-A treatment, improving all 5 parameters (erythema, scaling, dryness, stinging/burning and pruritus). The majority of the participants experienced a worsening of the side effects of tretinoin during the study, but tretinoin alone demonstrated higher worsing scores than tretinoin + Cetaphil DermaControl Moisturizer. The differences were statistically significant for erythema, scaling and dryness.

Unsurprisingly, a majority of the investigators and patients favoured the side of the face treated with Cetaphil DermaControl Moisturizer over the side treated with Retin-A alone.

Compared to baseline, skin hydration was increased on the side of the face treated with Cetaphil DermaControl Moisturizer + Retin-A, whereas it was unchanged or slightly decreased for the side treated with Retin-A only. However, significant differences were noted only on weeks 1 and 3.

The vast majority (96.7%) of the subjects had a pleasant or very pleasant impression of the Cetaphil DermaControl Moisturizer, and 91.4% stated that they would recommend or strongly recommend it.

The role of skin care as an integral component in the management of acne vulgaris: part 1: the importance of cleanser and moisturizer ingredients, design, and product selection.

Products

Cetaphil DermaControl Moisturizer

Results / Report

Application of the Cetaphil DermaControl Moisturizer reduced facial shine by up to 8 hours in some patients. Skin shine and surface sebum levels were found to have been reduced on the forehead and cheeks after application, according to Sebumeter and Sebutape measurements.