Cetaphil Moisturizing Cream

Cetaphil Moisturizing Cream soothes dry, sensitive skin by improving skin hydration, skin roughness and skin sensitivity. It helps repair the skin barrier, making it useful for those suffering from acne, rosacea and psoriasis.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Increased skin hydration

Mild

Improves skin dryness compared to no treatment in patients with acne, rosacea and psoriasis.

C

Smoother skin

Mild

Decreases skin roughness, probably because it improves the severity of desquamation.

D

Enhanced barrier function

Mild

Improvements in skin dryness, roughness, desquamation and skin sensitivity indicate that it contributes to the restoration of the skin barrier.

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Ingredients


Water, Glycerin, Petrolatum, Dicaprylyl Ether, Dimethicone, Glyceryl Stearate, Cetyl Alcohol, Sweet Almond Oil, PEG-30 Stearate, Tocopheryl Acetate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Dimethiconol, Benzyl Alcohol, Phenoxyethanol, Methylparaben, Propylparaben, Glyceryl Acrylate/Acrylic Acid Copolymer, Propylene Glycol, Disodium Edta, Sodium Hydroxide
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PETROLATUM (ANTISTATIC, EMOLLIENT) NO DATA NO DATA RESTRICTED (SOURCE)
DICAPRYLYL ETHER (EMOLLIENT, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
GLYCERYL STEARATE (EMOLLIENT, EMULSIFYING) 2 (SEE SOURCES) NO DATA ALLOWED (SOURCE)
CETYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 3 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
PRUNUS AMYGDALUS DULCIS OIL (SKIN CONDITIONING) 2 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PEG-30 STEARATE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
TOCOPHERYL ACETATE (ANTIOXIDANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER (EMULSION STABILISING, FILM FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONOL (ANTIFOAMING, EMOLLIENT, MOISTURISING) NO DATA NO DATA ALLOWED (SOURCE)
BENZYL ALCOHOL (PERFUMING, PRESERVATIVE, SOLVENT, VISCOSITY CONTROLLING) NO DATA NO DATA RESTRICTED (SOURCE)
PHENOXYETHANOL (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
GLYCERYL ACRYLATE/ACRYLIC ACID COPOLYMER (HUMECTANT, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PROPYLENE GLYCOL (HUMECTANT, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM HYDROXIDE (BUFFERING, DENATURANT) NO DATA NO DATA RESTRICTED (SOURCE)

Clinical Studies


Moisturizing cream ameliorates dryness and desquamation in participants not receiving topical psoriasis treatment.

Products

Cetaphil Moisturizing Cream

Trial Design

Uncontrolled

Duration

4 weeks

Subjects

30 patients with mild to moderate (5-10% body coverage) plaque psoriasis who were not being treated for their psoriasis. The majority were of Fitzpatrick phototype II.

Regimen

Subjects used the moisturizing cream twice daily, once in the morning and once in the evening. They also remained off all topical psoriasis medications and all other moisturizers.

Methods of Assessment

Determination of skin barrier function through measurements of transepidermal water loss (TEWL).

Measurement of skin hydration through corneometry.

Measurement of desquamation by sticky tape corneocyte counts using D-SQUAME® skin sampling discs. The number of dead cells was analyzed using a standardized scale, which was translated into 3 skin categories.

Participant ratings of the ease of use, perceived effectiveness, satisfaction and plans for future use of the moisturizing cream on a 10-point scale.

Side Effects

Not mentioned, but the cream was assessed by investigators to be well-tolerated.

Conflicts of Interest

Study was supported by from Galderma Laboratories, which owns the Cetaphil brand. The author was a consultant and researcher for the company.

Effects observed in this study:

There was no significant change in transepidermal water loss (TEWL) over the course of the study, indicating that the cream did not damage the skin barrier. Skin hydration improved significantly from baseline after the first and second weeks of treatment, but at week 4 the increase was not statistically significant. The severity of desquamation improved in the majority of the participants; 73% had very dry skin at the beginning of the study, but by the end of the study only 4% were classified as such. The remaining 46% had normal skin and 50% had dry skin.

62% of the subjects rated the cream at 7 or better in perceived effectiveness, 55% scored their satisfaction as 8 or better, and 62% reported their likeliness of future use of the cream as 10, the maximum value.

Beneficial use of Cetaphil moisturizing cream as part of a daily skin care regimen for individuals with rosacea.

Products

Cetaphil Moisturizing Cream

Trial Design

Split-face, controlled

Duration

15 days

Subjects

20 individuals with rosacea who were receiving twice-daily applications of metronidazole 0.75% gel for at least 15 days.

Regimen

Subjects applied 0.75% metronidazole gel and Cetaphil Moisturizing Cream twice daily to half of their faces, while the other half was treated only with metronidazole.

Methods of Assessment

Assessment of skin hydration by electrical capacitance.

Assessment of skin barrier by transepidermal water loss (TEWL).

Determination of skin sensitivity by lactic acid stinging test.

Side Effects

Unknown

Effects observed in this study:

Skin dryness, roughness and desquamation were all improved, as was skin sensitivity, showing that the moisturizing cream helped restore the skin barrier, and is beneficial for patients with rosacea.

Beneficial effect of a moisturizing cream as adjunctive treatment to oral isotretinoin or topical tretinoin in the management of acne.

Products

Cetaphil Moisturizing Cream

Trial Design

Split-face, controlled

Duration

15 days

Subjects

30 acne patients who had received oral isotretinoin for at least 2 months or topical tretinoin for at least one month.

Regimen

Subjects continued their treatments and applied Cetaphil Moisturizing Cream twice daily to half of their faces, leaving the other half untreated.

Methods of Assessment

Clinical assessments, which were confirmed by biophysical measurements.

Side Effects

Unknown

Effects observed in this study:

The moisturizing cream appeared to be able to relieve retinoid-induced skin irritation, since it significantly improved skin dryness, roughness and desquamation. It may be useful as an adjunctive treatment for acne patients on retinoid therapy.