Hyalogy

The Hyalogy product range appears to be effective in improving wrinkles as well as the moisturization and elasticity of the skin, but larger, controlled studies are needed to validate its efficacy.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

D

Increased skin hydration

Moderate

The skin was significantly more hydrated than untreated skin after 8 weeks of treatment.

D

Increased skin elasticity

Moderate

Skin elasticity improved after 2 weeks of treatment and continued throughout the remaining 6 weeks.

D

Smoother skin

Moderate

Roughness of the skin was significantly decreased after 15 days of treatment.

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Ingredients


NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
HYALURONIC ACID (ANTISTATIC, HUMECTANT, MOISTURISING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)

Clinical Studies


Efficacy of a New Topical Nano-hyaluronic Acid in Humans.

Products

Hyalogy P-effect

Trial Design

Observational, uncontrolled

Duration

8 weeks of treatment

Subjects

33 females with an average age of 45 years

Regimen

Mixed 1 to 1.5 mL of the lotion with 3-4 drops of the serum directly in the palm of the hand and applied the mixture to the entire face, including around the eyes. After the mixture was absorbed into the skin, applied a fingertip (no more than 1 mL) of the cream to the skin. This was performed twice daily.

Methods of Assessment

Hydration: Measured with a corneometer

Elasticity: Measured using a cutometer

Erythema: Measured using a chromameter

Skin topography: Measured by capturing the 3D surface structure of the skin using profilometry

Side Effects

Not reported

Conflicts of Interest

Study was sponsored by DermAvance Pharmaceuticals, which markets the Hyalogy products. None of the authors had any relevant conflicts of interest.

Effects observed in this study:

After 8 weeks of treatment, the skin was up to 96% more hydrated, up to 55% more elastic, wrinkles were up to 40% less deep, and measures of skin roughness showed a significantly finer skin structure.