Kerasal

Kerasal contains salicyclic acid and urea, which have been widely used as topical treatments for dry skin for decades.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Increased skin hydration

Strong

Significantly improved foot xerosis in just 4 weeks of treatment.

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Ingredients


Salicylic Acid (5%), Urea (10%), Petrolatum, PEG-8, Glycerin, PEG-40 Sorbitan Peroleate, PEG-40 Stearate, Polysorbate-80
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
SALICYLIC ACID (ANTIDANDRUFF, HAIR CONDITIONING, KERATOLYTIC, MASKING, PRESERVATIVE, SKIN CONDITIONING) NO DATA NO DATA RESTRICTED (SOURCE)
UREA (ANTISTATIC, BUFFERING, HUMECTANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PETROLATUM (ANTISTATIC, EMOLLIENT) NO DATA NO DATA RESTRICTED (SOURCE)
PEG-8 (HUMECTANT, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PEG-40 SORBITAN PEROLEATE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
PEG-40 STEARATE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
POLYSORBATE 80 (DENATURANT, EMULSIFYING, SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)

Clinical Studies


Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study.

Products

Lac-Hydrin

Kerasal

Trial Design

Double-blind, randomized, paired-comparison

Duration

4 weeks of treatment

Subjects

70 men and women with foot xerosis

Regimen

Applied Lac-Hydrin or Kerasal to the foot twice daily, in the morning and at bedtime. Patients massaged the foot until the medication had been properly absorbed.

Methods of Assessment

Investigator evaluations of the severity of xerosis on a 6-point scale

Side Effects

16 patients in the Lac-Hydrin group reported mild pruritus (itching) and 2 reported severe pruritus at the start of treatment, while 14 patients in the Kerasal group reported mild pruritus and 6 reported severe pruritus.

After 4 weeks of treatment, there was only 1 case of mild pruritus associated with Kerasal treatment, and only 1 case of moderate pruritus associated with Lac-Hydrin treatment.

Conflicts of Interest

Study was funded partly by Draxis Health, which used to own the Kerasal product line.

Effects observed in this study:

The severity of xerosis improved significantly after 4 weeks of therapy. Lac-Hydrin and Kerasal were equally effective.