Kinerase

There is modest evidence to show that Kinerase may be useful in reducing facial redness, and in improving the colour and roughness of the skin.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

D

Rosacea treatment

Mild

Decreased facial redness, but did not improve the counts of inflammatory lesions.

D

Skin lightening

Mild

Improved the appearance of mottled hyperpigmentation, as assessed by clinical scoring.

D

Smoother skin

Mild

Investigators found a reduction in the roughness of the skin after 4 and 8 weeks.

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Ingredients


Kinetin, Water, Glycerin, Stearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Grape Seed Oil, Cetyl Alcohol, Phenoxyethanol, Safflower Seed Oil, Ammonium Acryloyl Dimethyltaurate/VP Copolymer, Dimethicone, Peg-5 Soy Sterol, Aloe Barbadensis Leaf Juice, Ethylhexylglycerin, Panthenol, N-Acetyl-Glucosamine-6-Phosphate, Tocopheryl Acetate, Citric Acid, 3-Aminopropan-1-Ol
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
KINETIN (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
STEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, REFATTING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
GLYCERYL STEARATE (EMOLLIENT, EMULSIFYING) 2 (SEE SOURCES) NO DATA ALLOWED (SOURCE)
PEG-100 STEARATE (SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
VITIS VINIFERA SEED OIL (EMOLLIENT, SKIN CONDITIONING) 3 (SEE SOURCES) NO DATA ALLOWED (SOURCE)
CETYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 3 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
PHENOXYETHANOL (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
CARTHAMUS TINCTORIUS SEED OIL (MASKING, SKIN CONDITIONING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER (VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PEG-5 SOY STEROL (EMULSIFYING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ALOE BARBADENSIS LEAF JUICE (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ETHYLHEXYLGLYCERIN (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PANTHENOL (ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
N-ACETYL-GLUCOSAMINE-6-PHOSPHATE NO RECORDS FOUND
TOCOPHERYL ACETATE (ANTIOXIDANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CITRIC ACID (BUFFERING, CHELATING, MASKING) NO DATA NO DATA ALLOWED (SOURCE)
3-AMINOPROPAN-1-OL NO RECORDS FOUND

Clinical Studies


Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea.

Products

Kinerase

Trial Design

Open-label, uncontrolled

Duration

12 weeks of treatment

Subjects

18 men and women aged between 30-67 years, with mild to moderate rosacea

Regimen

Applied Kinerase to the entire face twice daily, and SPF 30 sunscreen when necessary

Methods of Assessment

Rosacea: Counts of inflammatory lesions (pustules and papules) and clinical ratings of the severity of erythema (redness) and telangiectasia

Photodamage: Clinical ratings of fine wrinkles, skin texture and mottled hyperpigmentation

Side Effects

None reported

Conflicts of Interest

1 of the 5 authors was Director of Medical Affairs at Valeant Pharmaceuticals International, which markets the Kinerase products.

Effects observed in this study:

Though there was no clinically appreciable decrease in the mean number of inflammatory lesions after 12 weeks, there was an average 32% decrease in facial redness. The investigator also found 59% of subjects to have shown moderate to marked improvement in rosacea. Skin became smoother by week 4, and continued to improve throughout the study period. Mottled hyperpigmentation was significantly improved by week 4, and continued to improve throughout the study period.