Lac-Hydrin

Lac-Hydrin contains 12% ammonium lactate, a strong moisturizing agent, and is therefore very effective in treating abnormally dry and scaly skin conditions such as xerosis.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Increased skin hydration

Strong

Completely healed or nearly completely healed moderate xerosis of the feet after just 4 weeks of treatment.

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Ingredients


Ammonium Lactate (12%), Cetyl Alcohol, Glycerin, Glyceryl Stearate, Laureth-4, Light Mineral Oil (Paraffinum Liquidum), Magnesium Aluminum Silicate, Methylcellulose, Methylparaben, Propylparaben, PEG-100 Stearate, Polyoxyl 40 Stearate, Propylene Glycol, Water
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AMMONIUM LACTATE (BUFFERING, HUMECTANT, KERATOLYTIC, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
CETYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 3 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
GLYCERYL STEARATE (EMOLLIENT, EMULSIFYING) 2 (SEE SOURCES) NO DATA ALLOWED (SOURCE)
LAURETH-4 (ANTISTATIC, EMULSIFYING, MASKING, SURFACTANT) 5 (SEE SOURCES) 4 (SEE SOURCES) ALLOWED (SOURCE)
PARAFFINUM LIQUIDUM (ANTISTATIC, EMOLLIENT, SKIN PROTECTING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
MAGNESIUM ALUMINUM SILICATE (ABSORBENT, ANTICAKING, OPACIFYING, VISCOSITY CONTROLLING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
METHYLCELLULOSE (BINDING, EMULSION STABILISING, STABILISING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PEG-100 STEARATE (SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PEG-8 STEARATE (EMULSIFYING, HUMECTANT, SURFACTANT) 3 (SEE SOURCES) 1 (SEE SOURCES) ALLOWED (SOURCE)
PROPYLENE GLYCOL (HUMECTANT, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)

Clinical Studies


A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis.

Products

Lactinol

Lac-Hydrin

Trial Design

Double-blind, randomized, comparative

Duration

4 weeks of treatment

Subjects

53 males and females with mild to moderate xerosis of both feet

Regimen

Applied Lactinol on one foot and Lac-Hydrin on the other foot

Methods of Assessment

Clinical assessment of xerosis severity on a 6-point scale at baseline, 2 weeks and 4 weeks

Side Effects

Mild to moderate itching in 2 patients and moderate to severe burning in 1 patient. 1 patient had a severe allergic reaction to both Lactinol and Lac-Hydrin.

Conflicts of Interest

Study was funded partly by Pedinol Pharmaceuticals, which markets the Lactinol cream.

Effects observed in this study:

Both Lactinol and Lac-Hydrin significantly improved the severity of skin dryness. After 4 weeks of therapy, 11 patients had both feet completely healed. Although both treatments were equally effective, 72% of patients preferred Lactinol.

Ammonium lactate 12% lotion versus a liposome-based moisturizing lotion for plantar xerosis. A double-blind comparison study.

Products

Lac-Hydrin

LyphaZome

Trial Design

Double-blind, randomized, bilateral, paired-comparison

Duration

4 weeks of treatment

Subjects

57 men and women with moderate to severe xerosis of both feet.

Regimen

Applied Lac-Hydrin or LyphaZome to the feet twice daily for 4 weeks.

Methods of Assessment

Clinical grading of xerosis severity on a 4-point scale.

Side Effects

Only 4 participants experienced itching and irritation.

Conflicts of Interest

None declared.

Effects observed in this study:

Both Lac-Hydrin and LyphaZome markedly improved foot xerosis. At the end of 4 weeks of treatment, all participants were either completely healed or had only slight xerosis remaining. Lac-Hydrin and LyphaZome were equally effective.

Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study.

Products

Lac-Hydrin

Kerasal

Trial Design

Double-blind, randomized, paired-comparison

Duration

4 weeks of treatment

Subjects

70 men and women with foot xerosis

Regimen

Applied Lac-Hydrin or Kerasal to the foot twice daily, in the morning and at bedtime. Patients massaged the foot until the medication had been properly absorbed.

Methods of Assessment

Investigator evaluations of the severity of xerosis on a 6-point scale

Side Effects

16 patients in the Lac-Hydrin group reported mild pruritus (itching) and 2 reported severe pruritus at the start of treatment, while 14 patients in the Kerasal group reported mild pruritus and 6 reported severe pruritus.

After 4 weeks of treatment, there was only 1 case of mild pruritus associated with Kerasal treatment, and only 1 case of moderate pruritus associated with Lac-Hydrin treatment.

Conflicts of Interest

Study was funded partly by Draxis Health, which used to own the Kerasal product line.

Effects observed in this study:

The severity of xerosis improved significantly after 4 weeks of therapy. Lac-Hydrin and Kerasal were equally effective.