Lactinol

Apart from its potent moisturizing effect on the skin, Lactinol is also very well-liked by patients, which can lead to greater patient adherence and usage.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Increased skin hydration

Strong

Significantly improved foot xerosis in just 4 weeks, and is preferred over Lac-Hydrin.

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Ingredients


Lactic Acid (10%), Water, Isopropyl Palmitate, Cetyl Alcohol, Glyceryl Stearate, PEG-100 Stearate, Glycerin, PEG-40 Stearate, Caprylic/Capric Triglyceride, Lecithin, Dimethicone, EDTA, Methylparaben, Propylparaben, Diazolidinyl Urea, Sodium Benzoate
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
LACTIC ACID (BUFFERING, HUMECTANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
ISOPROPYL PALMITATE (ANTISTATIC, BINDING, EMOLLIENT, PERFUMING, SKIN CONDITIONING, SOLVENT) 4 (SEE SOURCES) 1 (SEE SOURCES) ALLOWED (SOURCE)
CETYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 3 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
GLYCERYL STEARATE (EMOLLIENT, EMULSIFYING) 2 (SEE SOURCES) NO DATA ALLOWED (SOURCE)
PEG-100 STEARATE (SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PEG-40 STEARATE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
CAPRYLIC/CAPRIC TRIGLYCERIDE (EMOLLIENT, MASKING, PERFUMING, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
LECITHIN (ANTISTATIC, EMOLLIENT, EMULSIFYING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
EDTA (CHELATING) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DIAZOLIDINYL UREA (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM BENZOATE (ANTICORROSIVE, MASKING, PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)

Clinical Studies


A comparative study of lactic acid 10% and ammonium lactate 12% lotion in the treatment of foot xerosis.

Products

Lactinol

Lac-Hydrin

Trial Design

Double-blind, randomized, comparative

Duration

4 weeks of treatment

Subjects

53 males and females with mild to moderate xerosis of both feet

Regimen

Applied Lactinol on one foot and Lac-Hydrin on the other foot

Methods of Assessment

Clinical assessment of xerosis severity on a 6-point scale at baseline, 2 weeks and 4 weeks

Side Effects

Mild to moderate itching in 2 patients and moderate to severe burning in 1 patient. 1 patient had a severe allergic reaction to both Lactinol and Lac-Hydrin.

Conflicts of Interest

Study was funded partly by Pedinol Pharmaceuticals, which markets the Lactinol cream.

Effects observed in this study:

Both Lactinol and Lac-Hydrin significantly improved the severity of skin dryness. After 4 weeks of therapy, 11 patients had both feet completely healed. Although both treatments were equally effective, 72% of patients preferred Lactinol.