Neova Complex Cu3 Intensive Tissue Repair Crème

Neova's Tissue Repair Crème appears to provide a superior improvement in photoaged skin when used with other copper tripeptide-containing products following laser treatment.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

D

Wrinkle treatment

Mild

Appeared to better improve rhytids compared to the use of petrolatum-based products without copper tripeptide.

D

Smoother skin

Mild

Improved skin texture in patients after 12 weeks of treatment following laser resurfacing.

D

Skin lightening

Mild

Reduced erythema and improved pigmentation in patients after 12 weeks of treatment following laser resurfacing.

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Ingredients


Petrolatum, Water, Microcrystalline Wax, Mineral Oil, Glycerin, PVP Eicosene Copolymer, Carbomer, Benzyl Alcohol, Copper Tripeptide (Prezatide Copper Acetate), Sodium Chloride
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
PETROLATUM (ANTISTATIC, EMOLLIENT) NO DATA NO DATA RESTRICTED (SOURCE)
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
HYDROGENATED MICROCRYSTALLINE WAX (BINDING, EMULSION STABILISING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PARAFFINUM LIQUIDUM (ANTISTATIC, EMOLLIENT, SKIN PROTECTING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
VP/EICOSENE COPOLYMER (BINDING, FILM FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
CARBOMER (EMULSION STABILISING, GEL FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
BENZYL ALCOHOL (PERFUMING, PRESERVATIVE, SOLVENT, VISCOSITY CONTROLLING) NO DATA NO DATA RESTRICTED (SOURCE)
COPPER TRIPEPTIDE-1 (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM CHLORIDE (BULKING, MASKING, ORAL CARE, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)

Clinical Studies


Effects of topical copper tripeptide complex on CO2 laser-resurfaced skin.

Products

Neova Complex Cu3 Intensive Tissue Repair Crème

Neova Day Therapy SPF 20

Neova Night Therapy

Neova Crème De La Copper

Biomedic Gentle Healing Ointment

La Roche-Posay Toleriane

La Roche-Posay Tolerin

La Roche-Posay Hydraphase

Trial Design

Randomized, single-blind, comparative

Duration

12 weeks of treatment

Subjects

14 male and female patients aged 50-77 years, undergoing carbon dioxide circumoral laser treatments

Regimen

Petrolatum-based regimen: Applied Biomedic Gentle Healing Ointment in the period immediately after laser resurfacing, until re-epithelialization, together with frequent cleansing of the treated area. Used sunscreens and applied La Roche-Posay Toleriane, La Roche-Posay Tolerin and La Roche-Posay Hydraphase skin moisturizers daily.

Petrolatum and copper tripeptide-based regimen: Applied Neova Complex Cu3 Intensive Tissue Repair Crème in the period immediately after laser resurfacing, until re-epithelialization, together with frequent cleansing of the treated area. Used sunscreens and applied Neova Day Therapy SPF 20, Neova Night Therapy and Neova Crème De La Copper skin moisturizers daily.

Methods of Assessment

Quantitative colour analysis of standardized digital photographs to determine erythema

Qualitative assessments of erythema, rhytids and overall improvement as shown in the standardized digital photographs, by 2 board-certified plastic surgeons. Erythema was evaluated on a 4-point scale, rhytids using the 9-point Fitzpatrick wrinkle classification and overall improvement was assessed on a 5-point scale.

Side Effects

No adverse reactions or infections were reported in either group.

Conflicts of Interest

None declared.

Effects observed in this study:

Reduced erythema: Erythema began to diminish significantly 1 week after laser resurfacing, and patients regained their pre-operative skin hues between 5-11 weeks later. There were no significant differences in the two groups of patients.

Anti-wrinkle effect: Although there was not enough data to reach statistical significance, there was a trend towards superior improvement for patients using the copper tripeptide-containing products.

Overall improvement: Most patients had substantial or very good improvements, and there was no signficant difference in overall improvement between groups. However, all the patients in the copper-tripeptide group with more severe wrinkles experienced substantial overall improvements in their facial appearance, including skin texture, quality and pigmentation, compared to only 1 out of 6 patients using the petrolatum-based regimen.