Obagi Condition and Enhance System

The Obagi Condition and Enhance System does appear to be a complementary treatment modality to non-surgical facial rejuvenation procedures like IPL treatment and Botox, providing even greater reductions in hyperpigmentation and skin looseness when used for pre-conditioning.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Skin lightening

Strong

Significantly improves hyperpigmentation compared to treatment with Botox or IPL alone or in combination with a standard skin care regimen.

C

Tighter skin

Moderate

Improved skin looseness when used as an adjunct to IPL treatment, but did not lead to significant improvements when used together with Botox.

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Ingredients


Hydroquinone (4%), Tretinoin (0.05%)
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
HYDROQUINONE (STABILISING) NO DATA NO DATA BANNED (SOURCE)
TRETINOIN (0.05%) NO RECORDS FOUND

Clinical Studies


Further enhancement of facial appearance with a hydroquinone skin care system plus tretinoin in patients previously treated with botulinum toxin Type A.

Products

Obagi Condition and Enhance System

Trial Design

Multicenter, randomized, investigator-masked, parallel-group

Duration

120 days of treatment

Subjects

61 patients between 30-65 years of age, predominantly of Fitzpatrick phototype III, who received at least 2 Botox treatments for glabellar lines and/or crow's feet and/or forehead lines, one 24 hours before entering the study and one in the previous 3-6 months.

Regimen

Applied either the hydroquinone/tretinoin system (cleanser, toner, proprietary 4% hydroquinone, exfoliant, sunscreen plus 0.05% tretinoin cream) or a standard skin care regimen (cleanser, moisturizer, and sunscreen).

Methods of Assessment

Investigator evaluations of hyperpigmentation, fine lines/wrinkles, laxity, burning, dryness, peeling and erythema rated as none, trace, mild, moderate or severe.

Patient evaluations of the noticeability of facial wrinkles, evenness of facial colour tone, smoothness of facial skin, satisfaction with treatment, satisfaction with overall improvement in facial appearance and comparison with the effect of past treatment using Botox alone.

Side Effects

Mean levels of burning, dryness, peeling, and erythema were significantly greater with the hydroquinone/tretinoin regimen than with the standard skin care regimen, but mean levels of burning, dryness and peeling were less than mild overall while mean levels of erythema were less than moderate overall.

There was one adverse event possibly related to the study treatment -- one patient receiving treatment with the Obagi Condition and Enhance System experienced a burning sensation during eyebrow waxing.

Conflicts of Interest

Study is funded by Obagi Medical Products.

Effects observed in this study:

Mean scores for hyperpigmentation and fine lines/wrinkles were significantly lower with the Obagi Condition and Enhance System than with the standard skin care regimen as early as day 30. There was no statistically significant difference between the 2 groups with regards to mean laxity scores, but treatment with the Obagi Condition and Enhance System was associated with a significantly greater change in score from baseline.

Benefits of using a hydroquinone/tretinoin skin care system in patients undergoing intense pulsed light therapy for photorejuvenation: a placebo-controlled study.

Products

Obagi Condition and Enhance System

Trial Design

Single-blind, randomized, placebo-controlled

Duration

90 days of treatment

Subjects

36 men and women aged 35-54 years old, mainly of Fitzpatrick phototype III, and with moderate to severe facial wrinkling.

Regimen

Active: Used cleanser and applied toner, hydroquinone, exfoliant and sunscreen in the morning. Used cleanser and applied toner, hydroquinone and tretinoin cream in the evening.

Placebo: Used cleanser and applied moisturizer in the morning and evening. Also applied sunscreen in the morning.

All patients also received intense pulsed light (IPL) therapy on days 30 and 60.

Methods of Assessment

Physician evaluations of overall improvement in facial skin, the degree of hyperpigmentation, laxity, telangiectasia, tactile roughness and fine lines/wrinkles.

Patient ratings of overall improvement in facial appearance, facial skin texture, satisfaction with facial appearance and satisfaction with treatment regimen.

Side Effects

Patients using the Obagi Condition and Enhance System + IPL had greater burning and peeling than patients with placebo + IPL at day 30, but this resolved gradually thereafter.

Conflicts of Interest

Study is funded by Obagi Medical Products.

Effects observed in this study:

Physician ratings of overall improvements in the facial skin of patients who had used the Obagi Condition and Enhance System + IPL were significantly superior compared with placebo + IPL. At the end of the third month, 72% of patients on the active system + IPL reported an overall improvement of 75% in their facial appearance, versus only 19% of patients who had received placebo + IPL did so.

Levels of hyperpigmentation and skin laxity were also significantly lower with the Obagi Condition and Enhance System + IPL than with placebo + IPL at the end of the study. However, levels of telangiectasia were not significantly different between the 2 groups, and improvements in tactile roughness and fine lines/wrinkles were also comparable in both groups.