Obagi-C Rx System

There is modest evidence that the Obagi-C Rx System helps to brighten, tighten and smooth skin, but it contains hydroquinone, a substance of questionable safety.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

D

Skin lightening

Moderate

Led to more radiant and evenly toned skin in most subjects according to investigator and patient self-assessments.

D

Wrinkle treatment

Moderate

Results in visibly reduced lines and wrinkles, and also smooths skin.

D

Tighter skin

Mild

Reduced skin looseness in a minority (one-third) of subjects tested.

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Ingredients


NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
ASCORBIC ACID (ANTIOXIDANT, BUFFERING, MASKING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
HYDROQUINONE (STABILISING) NO DATA NO DATA BANNED (SOURCE)

Clinical Studies


Evaluation of a prescription strength 4% hydroquinone/10% L-ascorbic acid treatment system for normal to oily skin.

Products

Obagi-C Rx System Cleansing Gel

Obagi-C Rx System Balancing Toner

Obagi-C Rx System Clarifying Serum

Obagi-C Rx System Sunscreen SPF 30

Obagi-C Rx System Night Cream

Trial Design

Uncontrolled

Duration

12 weeks of treatment

Subjects

30 women between 18-40 years old, of Fitzpatrick phototypes II, III or IV, with minimal or mild facial photodamage and hyperpigmentation, and normal to oily facial skin

Regimen

Quarter-sized amount of cleansing gel twice daily

Balancing toner twice daily

Half dropperful of clarifying serum each morning

Sunscreen SPF 30 each morning and before sun exposure

Dime-sized amount of night cream each evening

Methods of Assessment

Clinical investigator assessments

Patient efficacy evaluations

Comparison of standard photographs taken before and at end of therapy

Side Effects

32% of the subjects experienced facial skin dryness, and a small proportion (<10%) experienced itching, peeling, redness of the skin, milia, rash, burning sensation, contact dermatitis, or acne. All the adverse events were mild. Most occurred in the first week of treatment, and resolved during the study period.

Conflicts of Interest

Both authors have ties with Obagi Medical Products -- one has received honoraria as a consultant for the company, while the other was an employee and shareholder.

Effects observed in this study:

Better overall appearance: 80% of the subjects had at least a 1-grade improvement in photodamage after 12 weeks, according to investigator evaluations. 97% of the subjects also considered the overall appearance of their skin to be at least moderately improved.

Lightening effect: Investigator evaluations found that 87% of the subjects had achieved at least a moderate (~50%) increase in lightness or brightness of the skin. 90% of the subjects also considered their skin be more radiant and more evenly toned.

Smoothing effect: 90% of the subjects had improvements in tactile roughness and 50% had improvements in fine lines and wrinkles post-treatment, as assessed by clinical investigators. 97% and 87% of the subjects also reported that their skin was smoother and that there was a visible reduction in their fine lines and wrinkles, respectively.

Tightening effect: 33% of the patients were assessed by investigators to have achieved at least a 1-grade improvement in skin laxity (looseness).