Olay Professional Pro-X Intensive Wrinkle Protocol

The Olay Professional Pro-X Age Repair Lotion, Wrinkle Smoothing Cream and Deep Wrinkle Treatment products can smooth wrinkles and improve the texture of the skin without adversely affecting the skin barrier.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Wrinkle treatment

Strong

Improved the appearance of fine lines and wrinkles, including those around the eyes. Overall wrinkle area was also reduced.

C

Enhanced barrier function

Moderate

Enhanced the integrity of the strateum corneum barrier, as measured by a decrease in water loss through the skin.

C

Smoother skin

Moderate

The texture of the skin became more even after 8 weeks, an effect that has been linked to enhanced barrier function.

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Ingredients


Avobenzone (3%), Homosalate (15%), Octisalate (5%), Octocrylene (2.6%), Oxybenzone (6%), Water, Glycerin, Niacinamide, Palmitoyl Pentapeptide-4, Carnosine, Panthenol, Tocopheryl Acetate, Polymethylsilsesquioxane, Polyethylene, Pentylene Glycol, Dimethicone, Palmitoyl Dipeptide-7, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Isohexadecane, Stearyl Alcohol, Cetyl Alcohol, Polysorbate 60, Peg-100 Stearate, Camellia Sinensis Leaf Extract, Allantoin, Methylparaben, Ethylparaben, Propylparaben, Cetearyl Alcohol, Cetearyl Glucoside, Disodium EDTA, Ascorbic Acid, Peg-4 Dilaurate, Peg-4 Laurate, Peg-4, Decyl Glucoside, Lactic Acid, Benzyl Alcohol, Iodopropynyl Butylcarbamate, Dimethiconol, Behenyl Alcohol, Stearic Acid, BHT, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, C13-14 Isoparaffin, Citric Acid, Laureth-7, Titanium Dioxide
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
BUTYL METHOXYDIBENZOYLMETHANE (UV ABSORBER, UV FILTER) NO DATA NO DATA ALLOWED (SOURCE)
HOMOSALATE (SKIN CONDITIONING, UV ABSORBER, UV FILTER) NO DATA NO DATA ALLOWED (SOURCE)
ETHYLHEXYL SALICYLATE (UV ABSORBER, UV FILTER) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
OCTOCRYLENE (UV ABSORBER, UV FILTER) NO DATA NO DATA ALLOWED (SOURCE)
BENZOPHENONE-3 (UV ABSORBER, UV FILTER) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
NIACINAMIDE (SMOOTHING) NO DATA NO DATA ALLOWED (SOURCE)
PALMITOYL PENTAPEPTIDE-4 (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
CARNOSINE (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PANTHENOL (ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
TOCOPHERYL ACETATE (ANTIOXIDANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
POLYMETHYLSILSESQUIOXANE (OPACIFYING) NO DATA NO DATA ALLOWED (SOURCE)
POLYETHYLENE (ABRASIVE, FILM FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PENTYLENE GLYCOL (SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PALMITOYL DIPEPTIDE-7 (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ACRYLAMIDE/SODIUM ACRYLOYLDIMETHYLTAURATE COPOLYMER (EMULSION STABILISING, VISCOSITY CONTROLLING) NO DATA NO DATA RESTRICTED (SOURCE)
ISOHEXADECANE (EMOLLIENT, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
STEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, REFATTING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
CETYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 3 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
POLYSORBATE 60 (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
PEG-100 STEARATE (SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CAMELLIA SINENSIS LEAF EXTRACT (ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, EMOLLIENT, HUMECTANT, MASKING, ORAL CARE, SKIN CONDITIONING, SKIN PROTECTING, TONIC, UV ABSORBER) NO DATA NO DATA ALLOWED (SOURCE)
ALLANTOIN (SKIN CONDITIONING, SKIN PROTECTING, SOOTHING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ETHYLPARABEN (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CETEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 1 (SEE SOURCES) ALLOWED (SOURCE)
CETEARYL GLUCOSIDE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
ASCORBIC ACID (ANTIOXIDANT, BUFFERING, MASKING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PEG-4 DILAURATE (EMULSIFYING) NO DATA NO DATA ALLOWED (SOURCE)
PEG-4 LAURATE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
PEG-4 (HUMECTANT, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
DECYL GLUCOSIDE (CLEANSING, EMULSION STABILISING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
LACTIC ACID (BUFFERING, HUMECTANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
BENZYL ALCOHOL (PERFUMING, PRESERVATIVE, SOLVENT, VISCOSITY CONTROLLING) NO DATA NO DATA RESTRICTED (SOURCE)
IODOPROPYNYL BUTYLCARBAMATE (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONOL (ANTIFOAMING, EMOLLIENT, MOISTURISING) NO DATA NO DATA ALLOWED (SOURCE)
BEHENYL ALCOHOL (BINDING, EMOLLIENT, EMULSION STABILISING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
STEARIC ACID (CLEANSING, EMULSIFYING, EMULSION STABILISING, MASKING, REFATTING, SURFACTANT) 3 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
BHT (ANTIOXIDANT, MASKING) NO DATA NO DATA ALLOWED (SOURCE)
HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER (EMULSION STABILISING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
C13-14 ISOPARAFFIN (EMOLLIENT, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
CITRIC ACID (BUFFERING, CHELATING, MASKING) NO DATA NO DATA ALLOWED (SOURCE)
LAURETH-7 (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
TITANIUM DIOXIDE (OPACIFYING, UV ABSORBER, UV FILTER) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
Water, Glycerin, Dimethicone, Niacinamide, Isohexadecane, Isopropyl Isostearate, Dimethiconol, Panthenol, Tocopheryl Acetate, Palmitoyl Dipeptide-7, Palmitoyl Pentapeptide-4, Elastin, C13-14 Isoparaffin, Stearyl Alcohol, Polyacrylamide, Peg-100 Stearate, Cetearyl Alcohol, Cetearyl Glucoside, Cetyl Alcohol, Benzyl Alcohol, Behenyl Alcohol, Polymethylsilsesquioxane, Sucrose Polycottonseedate, Laureth-7, Stearic Acid, Peg-4 Dilaurate, Peg-4 Laurate, Iodopropynyl Butylcarbamate, Peg-4, Decyl Glucoside, Titanium Dioxide, Tin Oxide, Lactic Acid, Citric Acid, Methylparaben, Ethylparaben, Propylparaben, Disodium EDTA, Ammonium Polyacrylate, Mica
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
NIACINAMIDE (SMOOTHING) NO DATA NO DATA ALLOWED (SOURCE)
ISOHEXADECANE (EMOLLIENT, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
ISOPROPYL ISOSTEARATE (BINDING, EMOLLIENT, SKIN CONDITIONING) 5 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DIMETHICONOL (ANTIFOAMING, EMOLLIENT, MOISTURISING) NO DATA NO DATA ALLOWED (SOURCE)
PANTHENOL (ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
TOCOPHERYL ACETATE (ANTIOXIDANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PALMITOYL DIPEPTIDE-7 (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PALMITOYL PENTAPEPTIDE-4 (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ELASTIN (SKIN CONDITIONING, SMOOTHING) NO DATA NO DATA ALLOWED (SOURCE)
C13-14 ISOPARAFFIN (EMOLLIENT, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
STEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, REFATTING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
POLYACRYLAMIDE (ANTISTATIC, BINDING, FILM FORMING) NO DATA NO DATA RESTRICTED (SOURCE)
PEG-100 STEARATE (SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CETEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 1 (SEE SOURCES) ALLOWED (SOURCE)
CETEARYL GLUCOSIDE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
CETYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 3 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
BENZYL ALCOHOL (PERFUMING, PRESERVATIVE, SOLVENT, VISCOSITY CONTROLLING) NO DATA NO DATA RESTRICTED (SOURCE)
BEHENYL ALCOHOL (BINDING, EMOLLIENT, EMULSION STABILISING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
POLYMETHYLSILSESQUIOXANE (OPACIFYING) NO DATA NO DATA ALLOWED (SOURCE)
SUCROSE POLYCOTTONSEEDATE (EMOLLIENT, EMULSIFYING, SKIN CONDITIONING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
LAURETH-7 (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
STEARIC ACID (CLEANSING, EMULSIFYING, EMULSION STABILISING, MASKING, REFATTING, SURFACTANT) 3 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PEG-4 DILAURATE (EMULSIFYING) NO DATA NO DATA ALLOWED (SOURCE)
PEG-4 LAURATE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
IODOPROPYNYL BUTYLCARBAMATE (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
PEG-4 (HUMECTANT, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
DECYL GLUCOSIDE (CLEANSING, EMULSION STABILISING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
TITANIUM DIOXIDE (OPACIFYING, UV ABSORBER, UV FILTER) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
TIN OXIDE (ABRASIVE, BULKING, OPACIFYING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
LACTIC ACID (BUFFERING, HUMECTANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
CITRIC ACID (BUFFERING, CHELATING, MASKING) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ETHYLPARABEN (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
AMMONIUM POLYACRYLATE (FILM FORMING, STABILISING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
MICA (OPACIFYING) NO DATA NO DATA ALLOWED (SOURCE)
Water, Glycerin, Niacinamide, Palmitoyl Dipeptide-7, Palmitoyl Pentapeptide-4, C12-15 Alkyl Benzoate, Dimethicone, Polyethylene, Stearyl Alcohol, Cetyl Palmitate, Retinyl Propionate, Tocopheryl Acetate, Caprylic/Capric Triglyceride, Cetyl Alcohol, Behenyl Alcohol, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Panthenol, Isohexadecane, Cetyl Ricinoleate, DMDM Hydantoin, Carbomer, Polysorbate 80, Polysorbate 20, Disodium EDTA, Peg-100 Stearate, Stearic Acid, Sodium Hydroxide, BHT, Decyl Glucoside, Iodopropynyl Butylcarbamate, Lactic Acid
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
NIACINAMIDE (SMOOTHING) NO DATA NO DATA ALLOWED (SOURCE)
PALMITOYL DIPEPTIDE-7 (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PALMITOYL PENTAPEPTIDE-4 (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
C12-15 ALKYL BENZOATE (ANTIMICROBIAL, EMOLLIENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
POLYETHYLENE (ABRASIVE, FILM FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
STEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, REFATTING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
CETYL PALMITATE (EMOLLIENT, MASKING, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
RETINYL PROPIONATE (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
TOCOPHERYL ACETATE (ANTIOXIDANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CAPRYLIC/CAPRIC TRIGLYCERIDE (EMOLLIENT, MASKING, PERFUMING, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
CETYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 3 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
BEHENYL ALCOHOL (BINDING, EMOLLIENT, EMULSION STABILISING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER (ANTICAKING, EMULSION STABILISING, FILM FORMING, OPACIFYING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PANTHENOL (ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ISOHEXADECANE (EMOLLIENT, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
CETYL RICINOLEATE (EMOLLIENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
DMDM HYDANTOIN (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
CARBOMER (EMULSION STABILISING, GEL FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
POLYSORBATE 80 (DENATURANT, EMULSIFYING, SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
POLYSORBATE 20 (EMULSIFYING, SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PEG-100 STEARATE (SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
STEARIC ACID (CLEANSING, EMULSIFYING, EMULSION STABILISING, MASKING, REFATTING, SURFACTANT) 3 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SODIUM HYDROXIDE (BUFFERING, DENATURANT) NO DATA NO DATA RESTRICTED (SOURCE)
BHT (ANTIOXIDANT, MASKING) NO DATA NO DATA ALLOWED (SOURCE)
DECYL GLUCOSIDE (CLEANSING, EMULSION STABILISING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
IODOPROPYNYL BUTYLCARBAMATE (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
LACTIC ACID (BUFFERING, HUMECTANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)

Clinical Studies


A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen.

Products

Olay Foaming Face Wash

Olay Complete All Day Moisture Lotion Sensitive Skin SPF 15

Olay Professional Pro-X Age Repair Lotion SPF 30

Olay Professional Pro-X Wrinkle Smoothing Cream

Olay Professional Pro-X Deep Wrinkle Treatment

Renova

Neutrogena Healthy Defense Daily Moisturizer SPF 30

Trial Design

Randomised, controlled, parallel-group, not blinded

Duration

2 weeks of preconditioning followed by 8 weeks of treatment.

50 subjects also continued treatment for an additional 16 weeks.

Subjects

196 women aged 40-65 and of Fitzpatrick phototypes I, III or III, with moderate to moderately severe periorbital wrinkles on both sides of the face.

Regimen

Preconditioning: 2 weeks using a mild facial cleanser (Olay Foaming Face Wash) and a facial moisturizer (Olay Complete All Day Moisture Lotion Sensitive Skin).

NPP regimen: Applied Olay Professional Pro-X Age Repair Lotion in the morning and Olay Professional Pro-X Wrinkle Smoothing Treatment in the evening. In addition, subjects applied Olay Professional Pro-X Deep Wrinkle Treatment twice daily on areas of concern, prior to the daytime lotion and the night cream.

Tretinoin regimen: Applied Renova to the entire face every other evening and Neutrogena Healthy Defense Daily Moisturizer every morning for the first 2 weeks. Renova was applied every evening after the initial 2 weeks.

Methods of Assessment

Fine lines and wrinkles: Expert visual grading of high-resolution digital images using the REAL 3.0 system taken at baseline and at 8 and 24 weeks. Dermatologists on the study advisory panel also evaluated representative study images for concurrence with the outcomes observed in expert grading.

Periorbital wrinkles and crow's feet: Analysis of images taken by the VISIA CR imaging system for changes in periorbital wrinkle area divided by assessment area.

Overall appearance and efficacy attributes: Patient self-assessment questionnaire

Side Effects

NPP regimen: Increased redness of the skin during the first 2 weeks of treatment. Some subjects reported a slight amount of irritation.

Tretinoin regimen: Compromise of the stratum corneum barrier, leading to an increase in transepidermal water loss. Increased skin redness and dryness in the first 8 weeks of treatment, which was restored to normal levels at week 16. Significantly more subjects also experienced itchiness, rash and skin peeling.

Conflicts of Interest

Study was funded by P&G Beauty, and all authors were either paid consultants to P&G or were P&G employees.

Effects observed in this study:

NPP regimen

Average 1-grade improvement in the appearance of periorbital wrinkles, and 28% of subjects had at least 2-grade improvements. The periorbital wrinkle area fraction was reduced by 17% on average. Subjects also recognized significant improvements in fine lines and wrinkles, eye lines and wrinkles, and deep wrinkles. Also, the appearance of facial fine lines and wrinkles continued to improve in subjects who underwent an additional 16 weeks of treatment.

The stratum corneum barrier was significantly improved after 24 weeks of treatment, and transepidermal water loss decreased as a result. Subjects also noticed improvements in the overall feel of their skin and a more even skin texture, after 8 weeks of treatment.

Tretinoin regimen

Periorbital wrinkles improved by less than 0.5-grade on average, though 13% of subjects had at least 2-grade improvements. There was a mean 11% reduction in periorbital wrinkle fraction. Moreover, subjects reported significant improvements in fine lines and wrinkles, eye lines and wrinkles, and deep wrinkles, though to a lesser extent than subjects on the NPP regimen. After 24 weeks of treatment however, there were no significant differences between the tretinoin regimen and the NPP regimen.

After 8 weeks of treatment, subjects noted improvements in the overall feel of their skin and a more even skin texture, but to a smaller extent than those on the NPP regimen.