Olay Total Effects 7X Visible Anti-Aging Vitamin Complex Fragrance Free

Those suffering from rosacea can benefit by adding this niacinamide-containing moisturizer to their regular skin therapy, as it enhances the barrier function of the skin and hence reduces skin sensitivity, and also mitigates rosacea signs and symptoms.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

B

Enhanced barrier function

Moderate

Enhanced barrier function as demonstrated by reduced irritation of the skin in response to a chemical probe, and reduced water loss from the skin.

B

Increased skin hydration

Mild

Improved the water content of the skin and decreased water loss from the skin.

D

Rosacea treatment

Moderate

Markedly reduced erythema severity in only 4 weeks, and improved dryness and skin peeling. Counts of inflammatory lesions were also lower.

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Ingredients


Water, Glycerin, Isohexadecane, Niacinamide, Dimethicone, Isopropyl Isostearate, Polyacrylamide, Zinc Oxide, Magnesium Ascorbyl Phosphate, Camellia Oleifera Leaf Extract, Sorbitan Stearate, Cetyl Alcohol, Sucrose Polycottonseedate, C13-14 Isoparaffin, Panthenol, Tocopheryl Acetate, Stearyl Alcohol, Titanium Dioxide, Dimethiconol, Benzyl Alcohol, Ethylparaben, Laureth-7, Propylparaben, Disodium EDTA, Peg-100 Stearate, Stearic Acid, Sodium Hydroxide, Methylparaben, Oleth 3-Phosphate, Ammonium Polyacrylate, Vitamin B3, Pro-Vitamin B5, Vitamin E
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ISOHEXADECANE (EMOLLIENT, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
NIACINAMIDE (SMOOTHING) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ISOPROPYL ISOSTEARATE (BINDING, EMOLLIENT, SKIN CONDITIONING) 5 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
POLYACRYLAMIDE (ANTISTATIC, BINDING, FILM FORMING) NO DATA NO DATA RESTRICTED (SOURCE)
ZINC OXIDE (BULKING, SKIN PROTECTING, UV ABSORBER) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
MAGNESIUM ASCORBYL PHOSPHATE (ANTIOXIDANT) NO DATA NO DATA ALLOWED (SOURCE)
CAMELLIA OLEIFERA LEAF EXTRACT (ASTRINGENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
SORBITAN STEARATE (EMULSIFYING) 0 (SEE SOURCES) 1 (SEE SOURCES) ALLOWED (SOURCE)
CETYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 3 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
SUCROSE POLYCOTTONSEEDATE (EMOLLIENT, EMULSIFYING, SKIN CONDITIONING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
C13-14 ISOPARAFFIN (EMOLLIENT, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
PANTHENOL (ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
TOCOPHERYL ACETATE (ANTIOXIDANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
STEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, REFATTING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
TITANIUM DIOXIDE (OPACIFYING, UV ABSORBER, UV FILTER) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DIMETHICONOL (ANTIFOAMING, EMOLLIENT, MOISTURISING) NO DATA NO DATA ALLOWED (SOURCE)
BENZYL ALCOHOL (PERFUMING, PRESERVATIVE, SOLVENT, VISCOSITY CONTROLLING) NO DATA NO DATA RESTRICTED (SOURCE)
ETHYLPARABEN (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
LAURETH-7 (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PEG-100 STEARATE (SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
STEARIC ACID (CLEANSING, EMULSIFYING, EMULSION STABILISING, MASKING, REFATTING, SURFACTANT) 3 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SODIUM HYDROXIDE (BUFFERING, DENATURANT) NO DATA NO DATA RESTRICTED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
OLETH-3 PHOSPHATE (SURFACTANT) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
AMMONIUM POLYACRYLATE (FILM FORMING, STABILISING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
NIACIN (ANTISTATIC, SMOOTHING) NO DATA NO DATA ALLOWED (SOURCE)
PRO-VITAMIN B5 NO RECORDS FOUND
TOCOPHEROL (ANTIOXIDANT, MASKING, SKIN CONDITIONING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)

Clinical Studies


Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea.

Products

Olay Active Hydrating Beauty Fluid - Sensitive Skin

Olay Foaming Face Wash - Sensitive Skin

Olay Sensitive Skin Beauty Bar

Olay Total Effects 7X Visible Anti-Aging Vitamin Complex Fragrance Free

Trial Design

Randomized, investigator-blind, controlled

Duration

2 weeks of washout, followed by 4 weeks of treatment

Subjects

50 females with a median age of 45 years, who were of Fitzpatrick phototypes I, II or III and had advanced subtype 1 or 2 rosacea.

Regimen

Washout: Applied regular facial moisturizier (Olay Hydrating Beauty Fluid - Sensitive Skin) to the face in the morning and evening for the initial 2 weeks. Used cleansers (Olay Foaming Face Wash - Sensitive Skin and Olay Sensitive Skin Beauty Bar) for facial and body cleansing.

Treatment: Applied facial moisturizer containing 2% niacinamide (Olay Total Effects 7X Visible Anti-Aging Vitamin Complex Fragrance Free) twice daily in the morning and evening for 4 weeks. Used cleansers (Olay Foaming Face Wash - Sensitive Skin and Olay Sensitive Skin Beauty Bar) for facial and body cleansing.

Comparison: Subjects applied Olay Total Effects 7X Visible Anti-Aging Vitamin Complex Fragrance Free to one randomly chosen forearm each time they applied the product to their face, leaving the other forearm as an untreated control.

Methods of Assessment

Rosacea: Clinical evaluations of rosacea presence and severity, counts of inflammatory lesions and patient self-evaluations via a questionnaire.

Stratum corneum barrier function: Transepidermal water loss measured using the DermaLab, plus a DMSO chemical probe for supplementary information.

Skin hydration: Skin capacitance measured using the Corneometer CM825.

Side Effects

None reported.

Conflicts of Interest

Study is financially supported by a grant from P&G. 2 of the 3 authors are employed by P&G and hold shares in the company.

Effects observed in this study:

Transepidermal water loss and the mean wheal-and-erythema responses were significantly lower for the treated compared to the untreated forearm, indicating an improved stratum corneum barrier. Transepidermal water loss measured on the cheeks also decreased. Treated forearms were also significantly more hydrated than the untreated forearms, as shown by the increase in mean skin capacitance values.

Facial erythema, the hallmark of rosacea, decreased markedly over the 4 weeks of treatment. Skin peeling and inflammatory lesion counts also declined. According to the investigator's global assessment of rosacea, 96% of subjects showed global improvement.