Prevage MD

Prevage MD is an anti-aging treatment that is capable of smoothing photoaged skin and diminishing facial fine lines and wrinkles. It also leads to a striking increase in skin moisturization.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

D

Increased skin hydration

Strong

Skin hydration rose by 37% after 6 weeks' use, probably due to the moisturizing base.

D

Wrinkle treatment

Moderate

Clinical severity of fine lines and wrinkles declined by 29% following 6 weeks of treatment.

D

Smoother skin

Moderate

Improved skin roughness by 26% after 6 weeks of twice-daily usage.

Looking to buy Prevage MD?

Buy from Amazon.com.

Ingredients


Water, Cyclopentasiloxane, Dimethicone/Vinyl Dimethicone Crosspolymer, Pentylene Glycol, Peg-8, Glycerin, Phospholipids, Isopropyl Lauroyl Sarcosinate, Algae Extract, Ammonium Acryloyldimethyl Taurate/Vp Copolymer, Idebenone, Camellia Sinensis Leaf Extract, Sodium Hyaluronate, PPG-2 Isoceteth-20 Acetate, Propylene Glycol, Sodium PCA, Trehalose, Urea, Polyphosphorylcholine Glycol Acrylate, Deoxyarbutin, Ammonium Acryloyldimethyltaurate/Beheneth-25 Methacrylate Crossploymer, Caprylyl/Capryl Glucoside, Sodium Acrylate/Acryloyldimethyl Taurate Copolymer, Polyquarternium-51, Polyisobutene, Butylene Glycol, Sodium Hydroxide, Dimethylmethoxy Chromanol, Mica, Benzoic Acid, Methylparaben, Phenoxyethanol, Propylparaben, Sorbic Acid, Chlorphenesin, Red 4 (CI 14700), Titanium Dioxide
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
CYCLOPENTASILOXANE (EMOLLIENT, HAIR CONDITIONING, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER (VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PENTYLENE GLYCOL (SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
PEG-8 (HUMECTANT, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PHOSPHOLIPIDS (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ISOPROPYL LAUROYL SARCOSINATE (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ALGAE EXTRACT (EMOLLIENT, HUMECTANT, MASKING, ORAL CARE, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
AMMONIUM ACRYLOYLDIMETHYLTAURATE/VP COPOLYMER (VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
HYDROXYDECYL UBIQUINONE (ANTIOXIDANT) NO DATA NO DATA ALLOWED (SOURCE)
CAMELLIA SINENSIS LEAF EXTRACT (ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, EMOLLIENT, HUMECTANT, MASKING, ORAL CARE, SKIN CONDITIONING, SKIN PROTECTING, TONIC, UV ABSORBER) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM HYALURONATE (HUMECTANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PPG-2 ISOCETETH-20 ACETATE (EMULSIFYING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PROPYLENE GLYCOL (HUMECTANT, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SODIUM PCA (ANTISTATIC, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
TREHALOSE (HUMECTANT, MOISTURISING) NO DATA NO DATA ALLOWED (SOURCE)
UREA (ANTISTATIC, BUFFERING, HUMECTANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
POLYPHOSPHORYLCHOLINE GLYCOL ACRYLATE (FILM FORMING) NO DATA NO DATA ALLOWED (SOURCE)
DEOXYARBUTIN NO RECORDS FOUND
AMMONIUM ACRYLOYLDIMETHYLTAURATE/BEHENETH-25 METHACRYLATE CROSSPOLYMER (EMULSION STABILISING) NO DATA NO DATA ALLOWED (SOURCE)
CAPRYLYL/CAPRYL GLUCOSIDE (CLEANSING, FOAMING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER (ANTICAKING, EMULSION STABILISING, FILM FORMING, OPACIFYING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
POLYQUATERNIUM-51 (FILM FORMING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
POLYISOBUTENE (BINDING, FILM FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
BUTYLENE GLYCOL (HUMECTANT, MASKING, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SODIUM HYDROXIDE (BUFFERING, DENATURANT) NO DATA NO DATA RESTRICTED (SOURCE)
DIMETHYLMETHOXY CHROMANOL (ANTIOXIDANT) NO DATA NO DATA ALLOWED (SOURCE)
MICA (OPACIFYING) NO DATA NO DATA ALLOWED (SOURCE)
BENZOIC ACID (BULKING, MASKING, PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PHENOXYETHANOL (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SORBIC ACID (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
CHLORPHENESIN (ANTIMICROBIAL, PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
CI 14700 (COSMETIC COLORANT) NO DATA NO DATA ALLOWED (SOURCE)
TITANIUM DIOXIDE (OPACIFYING, UV ABSORBER, UV FILTER) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)

Clinical Studies


Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone.

Products

Prevage MD

Prevage

Trial Design

Blind, comparative

Duration

6 weeks of treatment

Subjects

41 women with moderate photoaging (dyschromic facial skin with fine lines and wrinkles) between the ages of 30 and 65.

Regimen

Applied either the 1% idebenone lotion (Prevage MD) or the 0.5% idebenone lotion (Prevage) to the entire face twice daily, once in the morning and once in the evening.

Methods of Assessment

Electrical conductance measurements of skin surface hydration

Expert grader assessment of improvements of skin roughness/dryness, fine lines/wrinkles, and overall global improvement on a 5-point scale, using high-resolution, standardized digital photographs taken at baseline, 3 weeks and 6 weeks.

Patient diaries and questionnaires to gauge perceived experiences with the product.

Side Effects

No recorded adverse events.

Conflicts of Interest

None declared.

Effects observed in this study:

Prevage MD: After 6 weeks of use of the 1% idebenone formulation, the women achieved a 26% decline in skin roughness/dryness, a 29% decline in fine lines/wrinkles, a 37% increase in skin hydration and an overall 33% improvement in the global assessment of photodamaged skin.

Prevage: At the end of the study, the subjects who had used the 0.5% idebenone lotion observed a 23% reduction in skin roughness/dryness, a 27% reduction in fine lines/wrinkles, a 37% increase in skin hydration and an overall 30% improvement in the global assessment of photodamaged skin.

Both products: Comparison of the digital photographs showed that there were visible improvements in periorbital rhytides and pigment dyschromia for both groups of subjects. Histological analysis revealed a general improvement in the epidermis, an increase in dermal collagen content, and decreases in matrix metalloproteinase-1, IL-6 and IL-1b.

Allergic contact dermatitis to hydroxydecyl ubiquinone (idebenone) following application of anti-ageing cosmetic cream.

Products

Prevage MD

Results / Report

A 38 year old actress experienced a sudden onset of a red, itchy, burning and swollen face after her second application of Prevage MD. The eruption resulted in severe facial redness and scaling and was accentuated around the eyes, leading to swelling below the eyes. Treatment with 1% hydrocortisone ointment twice daily and Aqueous Cream BP completely resolved the eruption after 4 weeks.

Patch testing showed a positive reaction to the 1% idebenone contained within Prevage MD, but not to any other constituents. She also had positive reactions to nickel sulfate and propolis.