Renova

Renova is an effective single treatment for wrinkles, owing to its tretinoin content. Tretinoin has well-established effects in smoothing the skin.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Wrinkle treatment

Moderate

Reduced wrinkle area and improved the appearance of both fine and deep wrinkles as well as eye lines.

C

Smoother skin

Mild

Resulted in a better overall feel of the skin and a more even skin texture after 8 weeks.

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Ingredients


Tretinoin (0.02%), Mineral Oil, Sorbitol, Hydroxyoctacosanyl Hydroxystearate, Methoxy PEG-22/Dodecyl Glycol Copolymer, PEG-45/Dodecyl Glycol Copolymer, Stearoxytrimethylsilane, Stearyl Alcohol, Dimethicone, Disodium EDTA, Butylated Hydroxytoluene, Citric Acid, Fragrance, Water
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
TRETINOIN (0.02%) NO RECORDS FOUND
PARAFFINUM LIQUIDUM (ANTISTATIC, EMOLLIENT, SKIN PROTECTING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
SORBITOL (HUMECTANT, PLASTICISER, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
HYDROXYOCTACOSANYL HYDROXYSTEARATE (EMOLLIENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
METHOXY PEG-22/DODECYL GLYCOL COPOLYMER (EMULSION STABILISING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PEG-45/DODECYL GLYCOL COPOLYMER (EMULSION STABILISING) NO DATA NO DATA ALLOWED (SOURCE)
STEAROXYTRIMETHYLSILANE (EMOLLIENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
STEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, REFATTING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
BHT (ANTIOXIDANT, MASKING) NO DATA NO DATA ALLOWED (SOURCE)
CITRIC ACID (BUFFERING, CHELATING, MASKING) NO DATA NO DATA ALLOWED (SOURCE)
FRAGRANCE (PERFUMING) NO DATA NO DATA NO DATA
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)

Clinical Studies


A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen.

Products

Olay Foaming Face Wash

Olay Complete All Day Moisture Lotion Sensitive Skin SPF 15

Olay Professional Pro-X Age Repair Lotion SPF 30

Olay Professional Pro-X Wrinkle Smoothing Cream

Olay Professional Pro-X Deep Wrinkle Treatment

Renova

Neutrogena Healthy Defense Daily Moisturizer SPF 30

Trial Design

Randomised, controlled, parallel-group, not blinded

Duration

2 weeks of preconditioning followed by 8 weeks of treatment.

50 subjects also continued treatment for an additional 16 weeks.

Subjects

196 women aged 40-65 and of Fitzpatrick phototypes I, III or III, with moderate to moderately severe periorbital wrinkles on both sides of the face.

Regimen

Preconditioning: 2 weeks using a mild facial cleanser (Olay Foaming Face Wash) and a facial moisturizer (Olay Complete All Day Moisture Lotion Sensitive Skin).

NPP regimen: Applied Olay Professional Pro-X Age Repair Lotion in the morning and Olay Professional Pro-X Wrinkle Smoothing Treatment in the evening. In addition, subjects applied Olay Professional Pro-X Deep Wrinkle Treatment twice daily on areas of concern, prior to the daytime lotion and the night cream.

Tretinoin regimen: Applied Renova to the entire face every other evening and Neutrogena Healthy Defense Daily Moisturizer every morning for the first 2 weeks. Renova was applied every evening after the initial 2 weeks.

Methods of Assessment

Fine lines and wrinkles: Expert visual grading of high-resolution digital images using the REAL 3.0 system taken at baseline and at 8 and 24 weeks. Dermatologists on the study advisory panel also evaluated representative study images for concurrence with the outcomes observed in expert grading.

Periorbital wrinkles and crow's feet: Analysis of images taken by the VISIA CR imaging system for changes in periorbital wrinkle area divided by assessment area.

Overall appearance and efficacy attributes: Patient self-assessment questionnaire

Side Effects

NPP regimen: Increased redness of the skin during the first 2 weeks of treatment. Some subjects reported a slight amount of irritation.

Tretinoin regimen: Compromise of the stratum corneum barrier, leading to an increase in transepidermal water loss. Increased skin redness and dryness in the first 8 weeks of treatment, which was restored to normal levels at week 16. Significantly more subjects also experienced itchiness, rash and skin peeling.

Conflicts of Interest

Study was funded by P&G Beauty, and all authors were either paid consultants to P&G or were P&G employees.

Effects observed in this study:

NPP regimen

Average 1-grade improvement in the appearance of periorbital wrinkles, and 28% of subjects had at least 2-grade improvements. The periorbital wrinkle area fraction was reduced by 17% on average. Subjects also recognized significant improvements in fine lines and wrinkles, eye lines and wrinkles, and deep wrinkles. Also, the appearance of facial fine lines and wrinkles continued to improve in subjects who underwent an additional 16 weeks of treatment.

The stratum corneum barrier was significantly improved after 24 weeks of treatment, and transepidermal water loss decreased as a result. Subjects also noticed improvements in the overall feel of their skin and a more even skin texture, after 8 weeks of treatment.

Tretinoin regimen

Periorbital wrinkles improved by less than 0.5-grade on average, though 13% of subjects had at least 2-grade improvements. There was a mean 11% reduction in periorbital wrinkle fraction. Moreover, subjects reported significant improvements in fine lines and wrinkles, eye lines and wrinkles, and deep wrinkles, though to a lesser extent than subjects on the NPP regimen. After 24 weeks of treatment however, there were no significant differences between the tretinoin regimen and the NPP regimen.

After 8 weeks of treatment, subjects noted improvements in the overall feel of their skin and a more even skin texture, but to a smaller extent than those on the NPP regimen.