Retin-A

The tretinoin found in Retin-A's formulation enables it to reduce the length and depth of wrinkles, though only slightly.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Wrinkle treatment

Mild

Statistically significant reductions in wrinkle length, depth and skin roughness, but these effects were not significantly different from those of the vehicle.

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Ingredients


Tretinoin
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
TRETINOIN NO RECORDS FOUND

Clinical Studies


Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment.

Products

Avène Ysthéal Cream (0.05% retinal)

Retin-A (0.05% tretinoin)

Avène Skin Recovery Cream

Trial Design

Double-blind, vehicle-controlled

Duration

44 weeks of treatment

Subjects

135 healthy outpatients of Fitzpatrick phototypes II, III and IV, and between 35-70 years of age, with facial wrinkles of moderate to severe intensity.

Regimen

Applied Avène Skin Recovery Cream every morning and 0.5 to 0.75g of Avène Ysthéal Cream or Retin-A to the entire face every evening. Other substances could only be used on the treated areas 2 hours after application. Applied sunscreen (SPF 20) to the face before outdoor activities.

Methods of Assessment

Optical profilometry of silicone skin replicas of the left crow's feet area.

Side Effects

Signs of local irritation were rare, but more frequent for treatment with Retin-A. Cases of irritation were mild to moderate and tended to occur within the first 18 weeks of treatment.

Conflicts of Interest

5 out of 7 authors worked at the Pierre-Fabre Research Institute, which belongs to the same company that markets Avène products.

Effects observed in this study:

Retinal regimen

Treatment with Avène Ysthéal Cream and Avène Skin Recovery Cream had induced significant improvements in wrinkle depth and skin smoothness by week 18. Further improvements were seen at week 44. However, there was no significant difference between this treatment and treatment with the vehicle.

Tretinoin regimen

By week 18, treatment with Retin-A had diminished the depth of fine wrinkles as well as the roughness of the skin, with further improvements observed at the end of the study. There were also no significant differences between treatment with Retin-A and treatment with the retinal vehicle. Retin-A and Avène Ysthéal Cream were found to be equally effective.