RevaléSkin

Preliminary research indicates that the combination of the RevaléSkin Facial Cleanser, Day and Night Creams can significantly improve photodamaged skin, including wrinkles, roughness and pigmentation.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Skin lightening

Moderate

Improved facial redness by 15% after 12 weeks in one study, and led to a 3-fold improvement in skin pigmentation after 6 weeks in another.

C

Wrinkle treatment

Moderate

Reduced the appearance of fine lines and wrinkles, including crow's feet, possibly by upregulating collagen production and inhibiting its degradation.

C

Enhanced barrier function

Mild

Led to a decline in transepidermal water loss, as opposed to the comparator system which resulted in an increase.

C

Smoother skin

Mild

Significantly improved skin roughness compared to a comparator regimen in one study, but did not result in significant improvement in a separate split-face study.

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Ingredients


Aqua, Sodium Laureth Sulfate, Cocamidoproylamine Oxide, Di-PPG-2 Myreth-10 Adipate, Sucrose Polysoyate, Glycerin, PEG-7 Glyceryl Cocoate, Glyceryl Stearate SE, Glycol Palmitate, Stearyl Alcohol, Hydroxypropyl Starch Phosphate, PEG-6 Lauramide, Coffee Arabica (Coffee) Seed Extract, Caprylic/Capric Triglyceride, Citrus Grandis (Grapefruit) Fruit Extract, Polysorbate 80, Silica, Alumina, Disodium EDTA, Citric Acid, Phenoxyethanol, Methylparaben, Ethylparaben, Butylparaben, Propylparaben, Isobutylparaben, CI 77891, CI 42090, CI 42053, CI 19140
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
SODIUM LAURETH SULFATE (CLEANSING, EMULSIFYING, FOAMING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
COCAMIDOPROPYLAMINE OXIDE (CLEANSING, FOAM BOOSTING, HAIR CONDITIONING, HYDROTROPE, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
DI-PPG-2 MYRETH-10 ADIPATE (EMOLLIENT, SKIN CONDITIONING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
SUCROSE POLYSOYATE (EMOLLIENT, EMULSIFYING) NO DATA NO DATA ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PEG-7 GLYCERYL COCOATE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
GLYCERYL STEARATE SE (EMULSIFYING) 3 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
GLYCOL PALMITATE (EMULSIFYING, OPACIFYING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
STEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, REFATTING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
HYDROXYPROPYL STARCH PHOSPHATE (BULKING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PEG-6 LAURAMIDE (EMULSIFYING) NO DATA NO DATA ALLOWED (SOURCE)
COFFEA ARABICA SEED EXTRACT (MASKING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
CAPRYLIC/CAPRIC TRIGLYCERIDE (EMOLLIENT, MASKING, PERFUMING, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
CITRUS GRANDIS (GRAPEFRUIT) EXTRACT (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
POLYSORBATE 80 (DENATURANT, EMULSIFYING, SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SILICA (ABRASIVE, ABSORBENT, ANTICAKING, BULKING, OPACIFYING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
ALUMINA (ABRASIVE, ABSORBENT, ANTICAKING, BULKING, OPACIFYING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
CITRIC ACID (BUFFERING, CHELATING, MASKING) NO DATA NO DATA ALLOWED (SOURCE)
PHENOXYETHANOL (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ETHYLPARABEN (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
BUTYLPARABEN (MASKING, PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ISOBUTYLPARABEN (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
CI 77891 (COSMETIC COLORANT) NO DATA NO DATA ALLOWED (SOURCE)
CI 42090 (COSMETIC COLORANT) NO DATA NO DATA ALLOWED (SOURCE)
CI 42053 (COSMETIC COLORANT) NO DATA NO DATA ALLOWED (SOURCE)
CI 19140 (COSMETIC COLORANT) NO DATA NO DATA ALLOWED (SOURCE)
Aqua, Glycerin, C12-15 Alkly Benzoate, Cyclomethicone, Cetly Ricinoleate, Cetearyl Glucoside, Pentylene Glycol, Hydrogenated Polydecene, Coffea Arabica (Coffee) Seed Extract, Dimethicone, Ceresin, Glyceryl Stearate, PEG-100 Stearate, Sodium PCA, Urea, Trehalose, Sodium Hyaluronate, Tocopheryl Acetate, Glycosphingolipids, Phospholipids, Cholesterol, Panthenol, Polyisobutene, Caprylic/Capric Triglyceride, Citrus Grandis (Grapefruit) Fruit Extract, Silica, Alumina, Steareth-10, Steareth-2, Triethanolamine, Polyacrylate-13, Magnesium Aluminum Silicate, Xanthan Gum, Polysorbate 20, Polyquaternium-51, Disodium EDTA, Phenoxyethanol, Ethylhexylglycerin, Methylparaben, Propylparaben, CI 77891, CI 42090, CI 42053, CI 19140
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
C12-15 ALKYL BENZOATE (ANTIMICROBIAL, EMOLLIENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
CYCLOMETHICONE (ANTISTATIC, EMOLLIENT, HAIR CONDITIONING, HUMECTANT, SOLVENT, VISCOSITY CONTROLLING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CETYL RICINOLEATE (EMOLLIENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
CETEARYL GLUCOSIDE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
PENTYLENE GLYCOL (SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
HYDROGENATED POLYDECENE (EMOLLIENT) NO DATA NO DATA ALLOWED (SOURCE)
COFFEA ARABICA SEED EXTRACT (MASKING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CERESIN (ANTISTATIC, BINDING, EMULSION STABILISING, HAIR CONDITIONING, OPACIFYING, VISCOSITY CONTROLLING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
GLYCERYL STEARATE (EMOLLIENT, EMULSIFYING) 2 (SEE SOURCES) NO DATA ALLOWED (SOURCE)
PEG-100 STEARATE (SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SODIUM PCA (ANTISTATIC, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
UREA (ANTISTATIC, BUFFERING, HUMECTANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
TREHALOSE (HUMECTANT, MOISTURISING) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM HYALURONATE (HUMECTANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
TOCOPHERYL ACETATE (ANTIOXIDANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
GLYCOSPHINGOLIPIDS (EMOLLIENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PHOSPHOLIPIDS (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
CHOLESTEROL (EMOLLIENT, EMULSIFYING, SKIN CONDITIONING, STABILISING, VISCOSITY CONTROLLING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PANTHENOL (ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
POLYISOBUTENE (BINDING, FILM FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
CAPRYLIC/CAPRIC TRIGLYCERIDE (EMOLLIENT, MASKING, PERFUMING, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
CITRUS GRANDIS (GRAPEFRUIT) EXTRACT (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
SILICA (ABRASIVE, ABSORBENT, ANTICAKING, BULKING, OPACIFYING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
ALUMINA (ABRASIVE, ABSORBENT, ANTICAKING, BULKING, OPACIFYING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
STEARETH-10 (EMULSIFYING, REFATTING, SURFACTANT) 4 (SEE SOURCES) 3 (SEE SOURCES) ALLOWED (SOURCE)
STEARETH-2 (EMULSIFYING, SURFACTANT) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
TRIETHANOLAMINE (BUFFERING, EMULSIFYING, MASKING, SURFACTANT) 2 (SEE SOURCES) 0 (SEE SOURCES) RESTRICTED (SOURCE)
POLYACRYLATE-13 (FILM FORMING) NO DATA NO DATA RESTRICTED (SOURCE)
MAGNESIUM ALUMINUM SILICATE (ABSORBENT, ANTICAKING, OPACIFYING, VISCOSITY CONTROLLING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
XANTHAN GUM (BINDING, EMULSIFYING, EMULSION STABILISING, GEL FORMING, SKIN CONDITIONING, SURFACTANT, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
POLYSORBATE 20 (EMULSIFYING, SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
POLYQUATERNIUM-51 (FILM FORMING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PHENOXYETHANOL (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
ETHYLHEXYLGLYCERIN (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CI 77891 (COSMETIC COLORANT) NO DATA NO DATA ALLOWED (SOURCE)
CI 42090 (COSMETIC COLORANT) NO DATA NO DATA ALLOWED (SOURCE)
CI 42053 (COSMETIC COLORANT) NO DATA NO DATA ALLOWED (SOURCE)
CI 19140 (COSMETIC COLORANT) NO DATA NO DATA ALLOWED (SOURCE)
Aqua (Mineral Spring Water), Sodium Hyaluronate & Water, Ceteth-20 & Glyceryl Stearate & Steareth-25 & Stearyl Alcohol, Dimethicone & Dimethicone Crosspolymer, Ethylhexyl Palmitate, Squalene (Phytosqualene), Vitis Vinifera (Grape) Seed Oil, Cetearyl Olivate & Sorbitan Olivate, Glycerin, Erythritol & Homarine HCl, Caprylic/Capric Triglyceride & Teprenone, Cetyl Palmitate & Sorbitan Palmitate, Ceratonia Siliqua Gum, Butylene Glycol & Palmitoyl Oligopeptide & Palmitoyl Tetrapeptide-3 & Polysorbate-20 & Carbomer, Tocopherol (Vitamin E) & Hypericum Perforatum Flower/Leaf/Stem Extract & Olea Europaea (Olive)Fruit Oil, Cetraria Islandica Extract, Cetyl Alcohol, Dimethicone, Panthenol (Pro Vitamin B5), Disodium Lauriminodipropionate Tocopheryl Phospates, Phenoxyethanol & Pichia\Resveratrol Ferment Extract, Phenoxyethanol & Ethylhexylglycerin, Maris Sal (Dead Sea Water), Rosa Centifolia Flower Extract, Lycium Barbarum Fruit Extract, Stearyl Alcohol, Rubus Ellipiticus Root Extract, Boron Nitride, Allantoin, Parfum (Fragrance), Dunaliella Salina Extract, Phoenix Dactylifera (Date) Fruit Extract & Propylene Glycol, Pentaerythrityl Tetra-di-t-butyl Hydroxyhycinnamate, Folic Acid, Geraniol, Citronellol, Coumarin, Alpha Isomethyl Ionone, Limonene, Linalool, Butylphenyl Methylpropional, Eugenol, Citral, Benzyl Alcohol, Benzyl Benzoate,Isoeugenol
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
SODIUM HYALURONATE (HUMECTANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CETETH-20 & GLYCERYL STEARATE & STEARETH-25 & STEARYL ALCOHOL NO RECORDS FOUND
DIMETHICONE CROSSPOLYMER (EMULSION STABILISING, HAIR FIXING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
ETHYLHEXYL PALMITATE (EMOLLIENT, PERFUMING) 4 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
SQUALENE (ANTISTATIC, EMOLLIENT, HAIR CONDITIONING, REFATTING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
VITIS VINIFERA SEED OIL (EMOLLIENT, SKIN CONDITIONING) 3 (SEE SOURCES) NO DATA ALLOWED (SOURCE)
CETEARYL OLIVATE & SORBITAN OLIVATE NO RECORDS FOUND
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ERYTHRITOL & HOMARINE HCL NO RECORDS FOUND
CAPRYLIC/CAPRIC TRIGLYCERIDE (EMOLLIENT, MASKING, PERFUMING, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
SORBITAN PALMITATE (EMULSIFYING) NO DATA NO DATA ALLOWED (SOURCE)
CERATONIA SILIQUA GUM (BINDING, EMOLLIENT, EMULSION STABILISING, FILM FORMING, MASKING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
BUTYLENE GLYCOL & PALMITOYL OLIGOPEPTIDE & PALMITOYL TETRAPEPTIDE-3 & POLYSORBATE-20 & CARBOMER NO RECORDS FOUND
TOCOPHEROL (VITAMIN E) & HYPERICUM PERFORATUM FLOWER/LEAF/STEM EXTRACT & OLEA EUROPAEA (OLIVE)FRUIT OIL NO RECORDS FOUND
CETRARIA ISLANDICA EXTRACT (CLEANSING, EMOLLIENT, SMOOTHING, SOOTHING) NO DATA NO DATA ALLOWED (SOURCE)
CETYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 3 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PANTHENOL (ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DISODIUM LAURIMINODIPROPIONATE TOCOPHERYL PHOSPHATES (ANTISTATIC, CLEANSING, FOAMING, HAIR CONDITIONING, HAIR FIXING, SKIN CONDITIONING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
PICHIA/RESVERATROL FERMENT EXTRACT (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PHENOXYETHANOL & ETHYLHEXYLGLYCERIN NO RECORDS FOUND
MARIS SAL (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ROSA CENTIFOLIA FLOWER EXTRACT (ASTRINGENT, MASKING, SKIN CONDITIONING, TONIC) NO DATA NO DATA ALLOWED (SOURCE)
LYCIUM BARBARUM FRUIT EXTRACT (ASTRINGENT, HAIR CONDITIONING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
STEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, REFATTING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
RUBUS ELLIPTICUS ROOT EXTRACT (HUMECTANT) NO DATA NO DATA ALLOWED (SOURCE)
BORON NITRIDE (ABSORBENT, OPACIFYING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ALLANTOIN (SKIN CONDITIONING, SKIN PROTECTING, SOOTHING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PARFUM (DEODORANT, MASKING, PERFUMING) NO DATA NO DATA ALLOWED (SOURCE)
DUNALIELLA SALINA EXTRACT (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PHOENIX DACTYLIFERA (DATE) FRUIT EXTRACT & PROPYLENE GLYCOL NO RECORDS FOUND
PENTAERYTHRITYL TETRA-DI-T-BUTYL HYDROXYHYDROCINNAMATE (ANTIOXIDANT) NO DATA NO DATA ALLOWED (SOURCE)
FOLIC ACID (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
GERANIOL (PERFUMING, TONIC) NO DATA NO DATA RESTRICTED (SOURCE)
CITRONELLOL (PERFUMING) NO DATA NO DATA RESTRICTED (SOURCE)
COUMARIN (PERFUMING) NO DATA NO DATA RESTRICTED (SOURCE)
ALPHA-ISOMETHYL IONONE (PERFUMING, SKIN CONDITIONING) NO DATA NO DATA RESTRICTED (SOURCE)
LIMONENE (DEODORANT, PERFUMING, SOLVENT) NO DATA NO DATA RESTRICTED (SOURCE)
LINALOOL (DEODORANT, PERFUMING) NO DATA NO DATA RESTRICTED (SOURCE)
BUTYLPHENYL METHYLPROPIONAL (PERFUMING) NO DATA NO DATA RESTRICTED (SOURCE)
EUGENOL (DENATURANT, PERFUMING, TONIC) NO DATA NO DATA RESTRICTED (SOURCE)
CITRAL (FLAVOURING, PERFUMING) NO DATA NO DATA RESTRICTED (SOURCE)
BENZYL ALCOHOL (PERFUMING, PRESERVATIVE, SOLVENT, VISCOSITY CONTROLLING) NO DATA NO DATA RESTRICTED (SOURCE)
BENZYL ISOEUGENOL (PERFUMING) NO DATA NO DATA ALLOWED (SOURCE)

Clinical Studies


Clinical Safety and Efficacy in Photoaged Skin With CoffeeBerry Extract, a Natural Antioxidant.

Products

RevaléSkin Facial Cleanser

RevaléSkin Day Cream

RevaléSkin Night Cream

Trial Design

Full-Face Protocol: Double-blind, uncontrolled

Split-Face Protocol: Double-blind, split-face, controlled

Duration

6 weeks of treatment

Subjects

30 women aged 31-71 years, with moderate photoaging

Regimen

Full Face Protocol: 20 subjects were randomly assigned to the full-face protocol, which involved using the RevaléSkin Facial Cleanser twice daily, the Day Cream in the morning and the Night Cream in the evening.

Split-Face Protocol: 10 subjects were randomly assigned to the split-face protocol. They received both the RevaléSkin products and vehicles, and were instructed to use each set of products on opposite sides of the face.

Methods of Assessment

Clinical evaluations at baseline, 3 weeks and 6 weeks using digital photographs of the right, left and full-face views. Skin roughness and dryness, fine lines and wrinkles, dyschromia and hyperpigmentation, and global improvement were graded on a 5-point scale.

Skin biopsies of 4 split-face participants

Side Effects

22 adverse events were reported in 13 participants. These included acne flare-ups (6 participants), redness (4 participants), burning (4 participants) and peeling (1 participant). All adverse events were mild in severity, and only 2 were considered related to the use of the study products.

Conflicts of Interest

The study was sponsored by Stiefel Laboratories, the original manufacturer of the RevaléSkin product line.

Effects observed in this study:

Clinical trial: Full-face subjects achieved an average global improvement of 27% after 6 weeks of treatment. Fine lines and wrinkles were improved by 16%, skin roughness and dryness by 18%, and pigmentation by 25%. Similarly, for the split-face participants the mean percentage improvement was greater on the side treated with the RevaléSkin products compared to the vehicle side for fine lines and wrinkles (24% versus 3%), roughness and dryness (10% versus 9%), pigmentation (15% versus 5%) and global improvement (29% versus 8%). The study did not appear to be statistically powered however.

Biopsy results: The results of immunostaining for collagen I, collagen IV, matrix metalloproteinase-1 (MMP-1) and IL-1β varied among the subjects, but there was a basic trend towards increased collagen as well as reduced MMP-1 and inflammation. There were also mild changes in the compactness of the stratum corneum and in the organizational arrangement of the epidermal layer that were consistent with improved skin texture and decreased fine lines and wrinkles.

A double-blind, randomized clinical trial evaluating the dermatologic benefits of coffee berry extract.

Products

RevaléSkin Facial Cleanser

RevaléSkin Day Cream

RevaléSkin Night Cream

Trial Design

Double-blind, randomized, controlled

Duration

12 weeks of treatment

Subjects

50 women aged at least 30 years, with moderately photodamaged skin

Regimen

Subjects were randomly assigned into 1 of 2 groups. One group washed their face twice daily with the RevaléSkin Facial Cleanser and applied the RevaléSkin Day Cream and Night Cream to their entire face, while the other group followed the same regimen but used a comparator system comprising a mild cleansing wash and a moisturizing lotion.

Methods of Assessment

Clinical evaluation of roughness, erythema, wrinkling, scaling and global photoaging every 3 weeks on a 6-point scale.

Assessment of skin hydration by corneometry and analysis of transepidermal water loss (TEWL).

Profilometry with silicone casts of the lateral orbital area at baseline, week 6 and week 12.

Side Effects

3 subjects in the active group and 1 subject in the control group had acne flare-ups, but did not discontinue the study.

Conflicts of Interest

The study was supported by an educational grant from Stiefel Laboratories, the original manufacturer of the RevaléSkin products.

Effects observed in this study:

At the end of the study, subjects using the RevaléSkin products had statistically significant improvements from baseline in skin wrinkling, roughness, erythema and scaling, compared to those in the comparator group. Transepidermal water loss was also lower in the group using the RevaléSkin products, but skin hydration was not significantly different between groups.