RoC Retin-OX

RoC's Retin-OX has robust anti-wrinkle effects, even when used over relatively short durations (e.g. 8 weeks).

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

B

Wrinkle treatment

Moderate

Reduced wrinkle area by 13% and maximum wrinkle length by 12% after just 8 weeks of treatment.

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Ingredients


Aqua, Retinol, Ascorbic Acid, Ethylhexyl Methoxycinnamate, Ethylhexyl Palmitate, Isononyl Isononanoate, Glycerin, Avobenzone, PEG-8, Styrene/Acrylates Copolymer, Cetearyl Alcohol, Stearyl Heptanoate, Polyethylene, PTFE, Dimethicone, Glyceryl Stearate, PEG-100 Stearate, Panthenol, Bisabolol, Magnesium Aspartate, Copper Gluconate, Zinc Gluconate, Linseed Acid, PEG-8 Laurate, Sodium Dodecylbenzenesulfonate, Squalane, Stearyl Alcohol, Stearyl Caprylate, Myristyl Alcohol, Caprylyl Glycol, Carbomer, Cetearyl Glucoside, Cetyl Alcohol, Acrylates Copolymer, Hydroxyethyl Acrylates/Sodium Acryloyldimethyl Taurate Copolymer, Polysorbate 20, Polysorbate 60, Xanthan Gum, Disodium EDTA, Sodium Hydroxide, BHA, BHT, Tocopheryl Acetate, Chlorphenesin, Methylparaben, Ethylparaben, Propylparaben, Phenoxyethanol, Parfum
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
RETINOL (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ASCORBIC ACID (ANTIOXIDANT, BUFFERING, MASKING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ETHYLHEXYL METHOXYCINNAMATE (UV ABSORBER, UV FILTER) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ETHYLHEXYL PALMITATE (EMOLLIENT, PERFUMING) 4 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ISONONYL ISONONANOATE (ANTISTATIC, EMOLLIENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
BUTYL METHOXYDIBENZOYLMETHANE (UV ABSORBER, UV FILTER) NO DATA NO DATA ALLOWED (SOURCE)
PEG-8 (HUMECTANT, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
STYRENE/ACRYLATES COPOLYMER (FILM FORMING, OPACIFYING) NO DATA NO DATA ALLOWED (SOURCE)
CETEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 1 (SEE SOURCES) ALLOWED (SOURCE)
STEARYL HEPTANOATE (EMOLLIENT, SKIN CONDITIONING) 4 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
POLYETHYLENE (ABRASIVE, FILM FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PTFE (BULKING) NO DATA NO DATA ALLOWED (SOURCE)
DIMETHICONE (ANTIFOAMING, EMOLLIENT, SKIN CONDITIONING, SKIN PROTECTING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
GLYCERYL STEARATE (EMOLLIENT, EMULSIFYING) 2 (SEE SOURCES) NO DATA ALLOWED (SOURCE)
PEG-100 STEARATE (SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PANTHENOL (ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
BISABOLOL (MASKING, SKIN CONDITIONING, SOOTHING) NO DATA NO DATA ALLOWED (SOURCE)
MAGNESIUM ASPARTATE (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
COPPER GLUCONATE (SKIN CONDITIONING, SKIN PROTECTING) NO DATA NO DATA ALLOWED (SOURCE)
ZINC GLUCONATE (DEODORANT, SKIN CONDITIONING) NO DATA NO DATA RESTRICTED (SOURCE)
LINSEED ACID (CLEANSING, EMOLLIENT, EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
PEG-8 LAURATE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM DODECYLBENZENESULFONATE (CLEANSING, EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
SQUALANE (EMOLLIENT, HAIR CONDITIONING, REFATTING, SKIN CONDITIONING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
STEARYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, REFATTING, SURFACTANT, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
STEARYL CAPRYLATE (EMOLLIENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
MYRISTYL ALCOHOL (EMOLLIENT, EMULSION STABILISING, FOAM BOOSTING, SKIN CONDITIONING, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 4 (SEE SOURCES) ALLOWED (SOURCE)
CAPRYLYL GLYCOL (EMOLLIENT, HAIR CONDITIONING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
CARBOMER (EMULSION STABILISING, GEL FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
CETEARYL GLUCOSIDE (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
CETYL ALCOHOL (EMOLLIENT, EMULSIFYING, EMULSION STABILISING, FOAM BOOSTING, MASKING, OPACIFYING, SURFACTANT, VISCOSITY CONTROLLING) 3 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
ACRYLATES COPOLYMER (ANTISTATIC, BINDING, FILM FORMING) NO DATA NO DATA ALLOWED (SOURCE)
HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER (EMULSION STABILISING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
POLYSORBATE 20 (EMULSIFYING, SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
POLYSORBATE 60 (EMULSIFYING, SURFACTANT) NO DATA NO DATA ALLOWED (SOURCE)
XANTHAN GUM (BINDING, EMULSIFYING, EMULSION STABILISING, GEL FORMING, SKIN CONDITIONING, SURFACTANT, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
SODIUM HYDROXIDE (BUFFERING, DENATURANT) NO DATA NO DATA RESTRICTED (SOURCE)
BHA (ANTIOXIDANT, MASKING) NO DATA NO DATA ALLOWED (SOURCE)
BHT (ANTIOXIDANT, MASKING) NO DATA NO DATA ALLOWED (SOURCE)
TOCOPHERYL ACETATE (ANTIOXIDANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CHLORPHENESIN (ANTIMICROBIAL, PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
ETHYLPARABEN (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PHENOXYETHANOL (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
PARFUM (DEODORANT, MASKING, PERFUMING) NO DATA NO DATA ALLOWED (SOURCE)

Clinical Studies


Evaluation of anti-wrinkle effects of a novel cosmetic containing retinol using the guideline of the Japan Cosmetic Industry Association.

Products

RoC Retin-OX

Trial Design

Randomized, investigator-blinded, controlled, split-face

Duration

8 weeks of treatment

Subjects

30 Japanese females aged 35-39 years, with fine wrinkles in the eye area

Regimen

Applied 0.3g of Retin-OX+ to half of the face twice a day after washing

Methods of Assessment

Observation by 2 investigators based on the guidelines of the Japanese Cosmetic Industry Association

Comparison of standard photographs by the investigators

Analysis of digital images of the skin by the Robo Skin Analyzer CS50

Side Effects

7 subjects complained of a burning sensation with faint redness of the skin on the applied site, but this disappeared in a few weeks without any medication.

Conflicts of Interest

None declared.

Effects observed in this study:

At the end of 8 weeks, 34% of subjects showed marked or moderate improvement according to investigator assessments. The Robo Skin Analyzer found a 13% reduction in wrinkle area and a 12% decline in the maximum length of the wrinkles. These effects were all significantly superior to that of the control.