SkinMedica Lytera Skin Brightening Complex

SkinMedica's Lytera Skin Brightening Complex is a hydroquinone-free product that seems live up to its claim, due to its formulation which includes several active ingredients that have proven lightening effects.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Skin lightening

Strong

Improved hyperpigmented skin to the same extent as 4% hydroquinone cream, via a variety of mechanisms.

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Ingredients


Water, Niacinamide, Butylene Glycol, Tetrahexyldecyl Ascorbate, Polyacrylate-13, Caprylic/Capric Triglyceride, Tetrapeptide-30, Hexylresorcinol, 4-Ethoxybenzaldehyde, Retinol, Licorice (Glycyrrhiza Glabra Root) Extract, Ethyl Linoleate, Dunaliella Salina Extract, Tocopherol, Squalane, Cetyl Ethylhexanoate, Glycerin, Polyisobutene, Polysorbate 20, Phytic Acid, Disodium EDTA, Ethylhexylglycerin, Potassium Sorbate, Phenoxyethanol.
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
NIACINAMIDE (SMOOTHING) NO DATA NO DATA ALLOWED (SOURCE)
BUTYLENE GLYCOL (HUMECTANT, MASKING, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
TETRAHEXYLDECYL ASCORBATE (ANTIOXIDANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
POLYACRYLATE-13 (FILM FORMING) NO DATA NO DATA RESTRICTED (SOURCE)
CAPRYLIC/CAPRIC TRIGLYCERIDE (EMOLLIENT, MASKING, PERFUMING, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
TETRAPEPTIDE-30 (SKIN CONDITIONING, SKIN PROTECTING) NO DATA NO DATA ALLOWED (SOURCE)
HEXYLRESORCINOL (ANTIMICROBIAL) NO DATA NO DATA ALLOWED (SOURCE)
4-ETHOXYBENZALDEHYDE (MASKING, PERFUMING) NO DATA NO DATA ALLOWED (SOURCE)
RETINOL (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
GLYCYRRHIZA GLABRA (LICORICE) STEM EXTRACT (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ETHYL LINOLEATE (EMOLLIENT, PERFUMING) NO DATA NO DATA ALLOWED (SOURCE)
DUNALIELLA SALINA EXTRACT (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
TOCOPHEROL (ANTIOXIDANT, MASKING, SKIN CONDITIONING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
SQUALANE (EMOLLIENT, HAIR CONDITIONING, REFATTING, SKIN CONDITIONING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CETYL ETHYLHEXANOATE (EMOLLIENT) NO DATA NO DATA ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
POLYISOBUTENE (BINDING, FILM FORMING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
POLYSORBATE 20 (EMULSIFYING, SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PHYTIC ACID (CHELATING) NO DATA NO DATA ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
ETHYLHEXYLGLYCERIN (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
POTASSIUM SORBATE (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
PHENOXYETHANOL (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)

Clinical Studies


Clinical efficacy and safety of a multimodality skin brightener composition compared with 4% hydroquinone.

Products

3 test formulations (BR1, BR2 and BR3)

4% hyddroquinone cream

Standard facial cleanser, moisturizer and SPF 30 physical sunscreen

Trial Design

Randomized, double-blind, half-face, comparative

Duration

12 weeks of treatment

Subjects

75 Caucasian women of Fitzpatrick phototypes I, II or III, aged between 30-65 years and with moderate to severe facial hyperpigmentation.

Regimen

Applied one of the test formulations or the generic hydroquinone cream to the assigned side of the face twice daily. Also used standard skin care products (facial cleanser, moisturizer and SPF 30 physical sunscreen) during the course of the study.

Methods of Assessment

Chroma Meter measurements of skin colour

Investigator evaluations of overall hyperpigmentation on a 10-point scale and global hyperpigmentation improvement on a 5-point scale.

Patient self-assessments regarding various skin parameters on the left and right sides of the face.

Side Effects

Product use induced transient erythema that resolved by week 12. There was mild burning/stinging with BR1, as well as transient and intermittent skin tightness with BR1 and BR2.

Conflicts of Interest

Study was funded by SkinMedica. 3 of the 6 authors were employed by SkinMedica and another was a consultant for the company.

Effects observed in this study:

2 of the test formulations, BR1 and BR3, produced statistically equivalent reductions in hyperpigmentation compared to hydroquinone after 12 weeks of treatment, attributable to the presence of SMA-432, an active ingredient in BR1 and BR3 but not in BR2. Further, BR1 seemed to have a faster onset of action which was attributed to the activity of SMA-013 that was present in BR1 but not BR3.

Chroma Meter measurements also showed statistically significant improvements in the brightness of the skin tone compared to baseline scores at week 8 for all 3 test formulations.

While all 4 products were generally well-received among participants, BR3 was the most favoured product in terms of user satisfaction. The hydroquinone cream was the least favoured.