StriVectin-SD

Originally meant for treating stretch marks, StriVectin-SD quickly gained favour for its effectiveness in easing fine lines, wrinkles and crow's feet upon its release.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

C

Wrinkle treatment

Moderate

Decreased the number of wrinkles by 14% and the average wrinkle length by 10% after 12 weeks. Less effective on deep wrinkles.

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Ingredients


Water, C12-15 Alkyl Benzoate, Sesame Oil, Caprylic/Capric Triglyceride, Sweet Almond Oil, Cetearyl Olivate, Sorbitan Olivate, Palmitoyl Pentapeptide-4, Phyllanthus Emblica Fruit Extract, Siegesbeckia Orientalis Extract, Polyglyceryl Methacrylate, Propylene Glycol, Palmitoyl Oligopeptide, Glucosamine HCL, Algae Extract, Yeast Extract, Urea, Butylene Glycol, Hydrocotyl (Centella Asiatica) Extract, Coneflower Extract, Hydrolyzed Wheat Protein, Hydrolyzed Wheat Starch, Imperata Cylindrica, Root Extract, Bearberry (Arctostaphylos Uva Ursi) Extract, Licorice PTH, Glycerin, PPG-12/SMDI Copolymer, Glyceryl Stearate, PEG-100 Stearate, Cocoa Butter, Stearic Acid, Shea Butter, Tocopheryl Acetate, Mango Butter, Peppermint Oil, Methylparaben, Xanthan Gum, Propylparaben, Triethanolamine, Butylene Glycol, DMDM Hydantoin, Iodopropynyl Butylcabamate, Disodium EDTA, Retinyl Palmitate, Tetrahexyldecyl Ascorbate
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
AQUA (SOLVENT) 0 0 ALLOWED (SOURCE)
C12-15 ALKYL BENZOATE (ANTIMICROBIAL, EMOLLIENT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
HYDROGENATED SESAME SEED OIL (BINDING, EMULSION STABILISING, HAIR CONDITIONING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
CAPRYLIC/CAPRIC TRIGLYCERIDE (EMOLLIENT, MASKING, PERFUMING, SKIN CONDITIONING, SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)
PRUNUS AMYGDALUS DULCIS OIL (SKIN CONDITIONING) 2 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CETEARYL OLIVATE (HAIR CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
SORBITAN OLIVATE (EMULSIFYING) NO DATA NO DATA ALLOWED (SOURCE)
PALMITOYL PENTAPEPTIDE-4 (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
PHYLLANTHUS EMBLICA FRUIT EXTRACT (HUMECTANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
SIGESBECKIA ORIENTALIS EXTRACT (SKIN CONDITIONING, TONIC) NO DATA NO DATA ALLOWED (SOURCE)
GLYCERYL POLYMETHACRYLATE (VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PROPYLENE GLYCOL (HUMECTANT, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PALMITOYL OLIGOPEPTIDE (CLEANSING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
GLUCOSAMINE HCL (ANTISTATIC, HAIR CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ALGAE EXTRACT (EMOLLIENT, HUMECTANT, MASKING, ORAL CARE, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
HYDROLYZED YEAST EXTRACT (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
UREA (ANTISTATIC, BUFFERING, HUMECTANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
BUTYLENE GLYCOL (HUMECTANT, MASKING, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
CENTELLA ASIATICA EXTRACT (CLEANSING, SKIN CONDITIONING, SMOOTHING, SOOTHING, TONIC) NO DATA NO DATA ALLOWED (SOURCE)
CONEFLOWER EXTRACT NO RECORDS FOUND
HYDROLYZED WHEAT PROTEIN (ANTISTATIC, HAIR CONDITIONING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
HYDROLYZED WHEAT STARCH (SKIN CONDITIONING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
IMPERATA CYLINDRICA ROOT EXTRACT (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
OAK ROOT EXTRACT (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ARCTOSTAPHYLOS UVA URSI LEAF EXTRACT (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
LICORICE PTH NO RECORDS FOUND
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
PPG-12/SMDI COPOLYMER (EMOLLIENT, FILM FORMING, HAIR FIXING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
GLYCERYL STEARATE (EMOLLIENT, EMULSIFYING) 2 (SEE SOURCES) NO DATA ALLOWED (SOURCE)
PEG-100 STEARATE (SURFACTANT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
THEOBROMA CACAO SEED BUTTER (EMOLLIENT, MASKING, SKIN CONDITIONING, SKIN PROTECTING) 4 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
STEARIC ACID (CLEANSING, EMULSIFYING, EMULSION STABILISING, MASKING, REFATTING, SURFACTANT) 3 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
BUTYROSPERMUM PARKII BUTTER (SKIN CONDITIONING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
TOCOPHERYL ACETATE (ANTIOXIDANT, SKIN CONDITIONING) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
MANGIFERA INDICA SEED BUTTER (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
MENTHA PIPERITA OIL (MASKING, PERFUMING, REFRESHING, TONIC) NO DATA NO DATA ALLOWED (SOURCE)
METHYLPARABEN (PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
XANTHAN GUM (BINDING, EMULSIFYING, EMULSION STABILISING, GEL FORMING, SKIN CONDITIONING, SURFACTANT, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
PROPYLPARABEN (PERFUMING, PRESERVATIVE) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
TRIETHANOLAMINE (BUFFERING, EMULSIFYING, MASKING, SURFACTANT) 2 (SEE SOURCES) 0 (SEE SOURCES) RESTRICTED (SOURCE)
BUTYLENE GLYCOL (HUMECTANT, MASKING, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
DMDM HYDANTOIN (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
IODOPROPYNYL BUTYLCARBAMATE (PRESERVATIVE) NO DATA NO DATA ALLOWED (SOURCE)
DISODIUM EDTA (CHELATING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
RETINYL PALMITATE (SKIN CONDITIONING) 2 (SEE SOURCES) 2 (SEE SOURCES) ALLOWED (SOURCE)
TETRAHEXYLDECYL ASCORBATE (ANTIOXIDANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)

Clinical Studies


Antiwrinkle Creams: A Comparative Study of Efficacy Between a New Antiaging Proprietary Formulation and a Market Leader.

Products

Alyria Intense Wrinkle Correction

StriVectin-SD

Trial Design

Double-blind, single-center, parallel-group

Duration

12 weeks of treatment

Subjects

62 women aged 40-55 years, of Fitzpatrick phototypes II, III or IV, and with moderate to severe wrinkles in the crow's feet area.

Regimen

Volunteers applied either the Alyria Intense Wrinkle Correction cream or the StriVectin-SD facial cream sparingly twice a day (morning and night), and massaged vigorously in a circular motion until absorbed.

Methods of Assessment

Prolifometry of the eye contour area

Digital image analysis of silicon replicas of the crow's feet to obtain skin topography

Comparison of partial-face frontal and angle profile photographs taken every month

Subjects' self-evaluation questionnaire on the perceived efficacy of product claims

Side Effects

Subjects reported minor discomfort (redness and a prickling and burning sensation), particularly around the eyes and lips, but these were temporary and lasted only the first few days of use. >20% of the volunteers assigned to use the StriVectin-SD product reported developing pimples.

Conflicts of Interest

Study was sponsored by Canderm Pharma, which markets the Alyria products, and the author is a consultant for the company.

Effects observed in this study:

Alyria Intense Wrinkle Correction:

The number of wrinkles decreased by 12% after 2 months and by 25% after 3 months. When the wrinkles were classified by depth, there was a 25% reduction in the number of class 1 wrinkles (0-55 μm), a 27% reduction in the number of class 2 wrinkles ( 55-100 μm) and a 23% reduction in the number of class 3 wrinkles (110-800 μm).

Wrinkle area too declined by 17% after the first month and was 39% lower by the end of the study. In addition, the total length of the wrinkles on patients using this product was significantly reduced by 11% and 37% over the same time periods, while the mean wrinkle length dropped by 18% after treatment. Individual results went as high as a 66% reduction in wrinkle number, a 80% decline in wrinkle surface area and a 54% decrease in mean wrinkle length.

These changes were progressive and were all statistically significant compared to baseline. A between groups comparison appears to have been conducted, but the results were not mentioned.

StriVectin-SD:

At the end of the 12 weeks, the total number of wrinkles had declined by 14%. The number of class 1 wrinkles dropped by 23% and the number of class 2 wrinkles by 14%, but no significant reduction was seen for the class 3 wrinkles, which were the deepest. The total area occupied by wrinkles also decreased by 15%, while the the total length of the wrinkles on patients using this product dropped by 18%. On average, wrinkle length was reduced by 10% at the end of the treatment.

These improvements were statistically significant compared to baseline, but were not progressive.