Vivida

Vivida supplements seem to be strikingly good at reversing the signs of skin aging. It boosts skin thickness, elasticity and moisture, and is also effective at tightening loose, sagging skin, effacing wrinkles and lightening dark spots or blotches on the skin.

Images


Effects


Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments

B

Increased skin thickness

Strong

Can double or more than double the thickness of both the epidermis and the dermis.

B

Increased skin elasticity

Strong

Raises the elasticity index of the skin by 50-70% over 3 months.

C

Tighter skin

Strong

Improves the clinical severity of skin laxity from moderate-to-severe to mostly absent.

C

Increased skin hydration

Strong

Improves the appearance of moderately or severely dry skin.

C

Wrinkle treatment

Moderate

Appears to be able to erase fine wrinkles and diminish deep wrinkles.

C

Skin lightening

Moderate

Needs more than 1.5 months to significantly reduce mottled hyperpigmentation of facial skin.

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Ingredients


Natural Marine Protein Complex, Horsetail Plant Extract, Microcrystalline Cellulose, Acerola Cherry (Malpighia Emarginata Fruit) Powder, Astaxanthin, Ascorbic Acid, Hydroxypropyl Cellulose, Natural Orange Flavour, Hydroxypropyl Methyl Cellulose, Cross-linked Carboxymethyl Cellulose, Titanium Dioxide, Iron Oxide, Riboflavin, Magnesium Stearate, Glycerin, Silicon Dioxide
NAME ANTIOXIDANT UV PROTECTION COMEDOGENIC IRRITANT SAFETY
NATURAL MARINE PROTEIN COMPLEX NO RECORDS FOUND
HORSETAIL PLANT EXTRACT NO RECORDS FOUND
MICROCRYSTALLINE CELLULOSE (ABSORBENT, ANTICAKING, BULKING, EMULSION STABILISING, OPACIFYING, STABILISING, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
MALPIGHIA EMARGINATA FRUIT POWDER (ABSORBENT) NO DATA NO DATA ALLOWED (SOURCE)
ASTAXANTHIN (SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
ASCORBIC ACID (ANTIOXIDANT, BUFFERING, MASKING, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
HYDROXYPROPYLCELLULOSE (BINDING, EMULSIFYING, EMULSION STABILISING, FILM FORMING, VISCOSITY CONTROLLING) 2 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
NATURAL ORANGE FLAVOUR NO RECORDS FOUND
HYDROXYPROPYL METHYLCELLULOSE (ANTISTATIC, BINDING, EMULSION STABILISING, FILM FORMING, SURFACTANT, VISCOSITY CONTROLLING) NO DATA NO DATA ALLOWED (SOURCE)
CROSS-LINKED CARBOXYMETHYL CELLULOSE NO RECORDS FOUND
TITANIUM DIOXIDE (OPACIFYING, UV ABSORBER, UV FILTER) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
IRON OXIDES (COSMETIC COLORANT) NO DATA NO DATA ALLOWED (SOURCE)
RIBOFLAVIN (COSMETIC COLORANT, SKIN CONDITIONING) NO DATA NO DATA ALLOWED (SOURCE)
MAGNESIUM STEARATE (ANTICAKING, BULKING, COSMETIC COLORANT, MOISTURISING) 1 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
GLYCERIN (DENATURANT, HUMECTANT, PERFUMING, SOLVENT) 0 (SEE SOURCES) 0 (SEE SOURCES) ALLOWED (SOURCE)
BARIUM/CALCIUM/SILICON/TITANIUM OXIDE (SOLVENT) NO DATA NO DATA ALLOWED (SOURCE)

Clinical Studies


Natural cartilage polysaccharides for the treatment of sun-damaged skin in females: a double-blind comparison of Vivida and Imedeen.

Products

Imedeen

Vivida

Trial Design

Double-blind, randomized, comparative

Duration

90 days of treatment

Subjects

30 women aged 40-60 years

Regimen

15 women were randomly allocated to receive Vivida while the other 15 received Imedeen, to be taken orally on a daily basis.

Methods of Assessment

Clinical examinations were conducted at baseline and day 90, where physicians graded skin thinning, laxity, wrinkles, mottles, dryness plus the brittleness of the hair and skin on a 3-point scale.

The thicknesses of the epidermis and dermis were measured 2 cm laterally from the left eye using Dermascan C.

The elasticity index of the skin from the left cheek was measured using Dermaflex A.

Side Effects

5 subjects in the Vivida group developed transient, mild pimples during the first weeks of treatment. No other adverse effects occurred.

Conflicts of Interest

None declared.

Effects observed in this study:

At baseline, all patients had moderate to severe thinning of the facial skin, skin laxity, skin dryness and wrinkles. The majority also had moderate to severe mottles and brittle nails, and approximately half had fragile hair.

By the end of the study, all of the patients treated with Vivida had skin of normal thickness, and most had either no or moderate wrinkles as well as mottles. None had dry skin, loose skin, brittle hair or brittle nails. The patients in the Imedeen group witnessed definite but less dramatic improvements in skin thinning, laxity, wrinkles, dryness, mottles and the fragility of their hair and nails. The difference between the 2 treatment groups was statistically significant for all parameters.

The patients who had taken Vivida also saw larger increases in epidermal thickness (86% versus 38%), dermal thickness (68% versus 21%) and skin elasticity (51% versus 17%) compared to the patients who had taken Imedeen.

Since the daily dose of Vivida contained 500 mg of active polysaccharides while the daily dose of Imedeen had been reduced to 380 mg (compred to 500 mg in an earlier study), the effect of the polysaccharides appear to be dose-dependent.

Special natural cartilage polysaccharides for the treatment of sun-damaged skin in females.

Products

Vivida

Trial Design

Randomized, double-blind, placebo-controlled

Duration

90 days of treatment

Subjects

30 women aged 40-60 years, with Fitzpatrick phototype II or III and moderate to severe solar elastosis.

Regimen

15 women were randomized to treatment with 500 mg/day of Vivida supplements, while the remaining 15 took 500 mg/day of the placebo tablets.

Methods of Assessment

Clinical assessments of the thinning of the skin, laxity, wrinkles, mottles, dryness of the skin, brittleness of the hair and the brittleness of the nails.

Measurements of the thickness of the epidermis and the dermis 2 cm laterally from the left eye using Dermascan C.

Measurement of elasticity index for skin on the left cheek using Dermaflex.

Side Effects

Some of the Vivida-treated patients experienced mild pimples during the first 3-4 weeks of treatment. No other adverse effects were reported.

Conflicts of Interest

None declared.

Effects observed in this study:

There was a definite improvement in the Vivida group after 45 days of treatment. Apart from mottles, all of the signs of photodamage (skin thinning, laxity, wrinkles, dryness, brittleness of hair and nails) were improved to a statistically significant extent relative to the placebo. After 90 days of treatment, the difference between the 2 groups had widened further, leading to the difference between the 2 groups results reaching even greater statistical significance. Skin dryness and the brittleness of the hair and nails were completely cured, and the number of mottles had decreased.

Similarly, a statistically significant difference was already seen in terms of epidermal thickness, dermal thickness and skin elasticity after 45 days of treatment, which was enhanced after 90 days of treatment. The mean epidermal thickness more than doubled and the mean dermal thickness nearly doubled in the Vivida-treated patients, whereas in the placebo-treated group these thicknesses were unchanged. Patients in the Vivida group also achieved an average 66% increase in the elasticity index, while the elasticity index was not improved in patients who had taken the placebo.