elure Advanced Skin Lightening

elure's Advanced Skin Lightening products are effective in lightening the skin of Asian women, and bring about significant changes after just 1 month of treatment.



Grade Level of Evidence
A Double-blind, controlled study with more than 50 participants.
B Controlled study that is single-blind or has less than 50 participants.
C Controlled or comparative study.
D Uncontrolled or observational study.
Grade Effect Size of Effect Comments


Skin lightening


More effective than 2% hydroquinone cream in making the skin more fair and in improving mottled hyperpigmentation.

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Lignin peroxidase (Ligninase - 2%)

Clinical Studies

A randomized and placebo-controlled study to compare the skin-lightening efficacy and safety of lignin peroxidase cream vs. 2% hydroquinone cream.


elure Advanced Skin Lightening products

2% hydroquinone cream

Trial Design

Randomized, double-blind, placebo-controlled, split-face, single-center


31 days of treatment


51 East Asian and Southeast Asian women aged 20-60 years


Applied a dime-sized amount of 2 lightening creams to the face in the morning and 2 other lightening creams in the evening, followed by an activator lotion after applying the creams.

Patients were also supplied with a cleanser for twice-daily use, and an SPF 15 sunscreen to be used regularly.

Methods of Assessment

Whole-face skin-lightening effect on the chin, cheeks and forehead were measured using a Mexameter.

Subjective grading of overall fairness and mottled hyperpigmentation by a dermatologist, on a 10-point scale.

Visual evaluation of changes using the VisioFace system.

Patient evaluation of product efficacy, their skin appearance, skin tone, radiance and lightening/whitening through a questionnaire.

Side Effects

8 patients experienced mild adverse events and withdrew from the study, but 5 of these reported the same adverse events on both sides on their faces, so it was concluded that these adverse events were not related to the active ingredient of lignin peroxidase treatment.

Conflicts of Interest

2 of the 3 authors were R&D consultants to Syneron, which markets the elure products.

Effects observed in this study:

83% of patients responded to treatment with the elure Advanced Skin Lightening products at 31 days. Mexameter measurements showed a mean reduction of 7.6% in the melanin index compared to baseline measurements, whereas the changes in the 2% hydroquinone or placebo group did not reach statistical significance. Between-groups comparisons revealed statistically significant differences in favour of the elure Advanced Skin Lightening products over 2% hydroquinone and the placebo creams as well.

Similarly, dermatologist evaluations of overall fairness improved more quickly and to a greater extent with treatment using the elure Advanced Skin Lightening products. The products also provided the best improvements in mottled hyperpigmentation compared to the other treatments.

Patients also preferred the elure Advanced Skin Lightening regimen over the other products, with more patients selecting it for making their skin look healthier, more radiant, fairer, more even-toned, smooth and refined, and translucent.