Effect of Hydroquinone + Tretinoin + Corticosteroid on Hyperpigmentation

Efficacy
Study Outcomes
French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial
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Evaluation of the safety and efficacy of a triple combination cream (hydroquinone, tretinoin, and fluocinolone) for treatment of melasma in Middle Eastern skin
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Objective assessment of erythema and pigmentation of melasma lesions and surrounding areas in long-term management regimens with triple combination
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Continuous therapy followed by a maintenance therapy regimen with a triple combination cream for melasma
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Side Effect
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