Safety and efficacy of topical metformin 30% cream versus triple combination cream (Kligman's formula) in treating melasma: A randomized controlled study

Study Design

Subject Type

Human

Trial Design

Randomised, Controlled

Trial Duration

56 days

Participants

40 (40 completed)

Efficacy

Intervention(s)			Outcome		Method		Effect	Description
Hydroquinone + Tretinoin + Corticosteroid			Melasma		Clinical grading		🠫	Sign in to read for free
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Metformin			Melasma		Clinical grading		🠫	Sign in to read for free
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Side Effects

Intervention(s)			Outcome		Effect	Description
Hydroquinone + Tretinoin + Corticosteroid			Hyperpigmentation		⇧	Sign in to read for free
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Metformin			Hyperpigmentation		⇧	Sign in to read for free
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Hydroquinone + Tretinoin + Corticosteroid			Irritation		⇧	Sign in to read for free
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Metformin			Irritation		⇧	Sign in to read for free
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Hydroquinone + Tretinoin + Corticosteroid			Skin Discomfort		⇧	Sign in to read for free
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Metformin			Skin Discomfort		⇧	Sign in to read for free
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Study Summary

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