Transforming Growth Factor Beta-1

Introduction

What is transforming growth factor beta-1?

Transforming growth factor beta-1 (TGF-β1) is a small protein that is known to modulate many biological processes, including cellular proliferation, the growth of blood vessels, wound healing, and the synthesis of collagen, elastin and glycosaminoglycans (R, R, R, R). It is expressed in the dermis, especially around blood vessels and ducts, but not in the epidermis (R).

Efficacy

Outcome				Grade		Effect		Evidence		Studies
Wrinkles				C		🠫 Slight		★★ Some		1 study 31 participants

Mechanisms

Show 1 more outcomes
Outcome	Grade	Effect	Evidence	Studies
Collagen	D	🠩🠩🠩 Marked	★ Basic	2 studies
Glycosaminoglycans	D	🠩🠩🠩 Marked	★ Basic	1 study
Hyaluronan Synthase	D	🠩🠩🠩 Marked	★ Basic	1 study
Fibronectin	D	🠩 Slight	★ Basic	1 study
Blood Vessels	D	🠩 Slight	★ Basic	1 study
Hyaluronidase	E	– No Effect	★ Basic	1 study

Latest Research

Transforming Growth Factor Beta-1

What is transforming growth factor beta-1?

Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects (2011)

Improvement in the appearance of wrinkles with topical transforming growth factor beta(1) and l-ascorbic acid (2006)

Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts (1987)