Wrinkles

Ingredients

Show 16 more ingredients
Ingredient	Grade	Effect	Evidence	Studies
Niacinamide	B	Slight Decrease	Good	3 studies 103 participants
Bakuchiol	C	Marked Decrease	Fair	1 study 44 participants
Retinol	C	Marked Decrease	Fair	4 studies 170 participants
Niacinamide + Sericin + Signaline	C	Slight Decrease	Fair	1 study 30 participants
Glycolic Acid	C	Slight Decrease	Fair	2 studies 63 participants
Ascorbic Acid	C	Slight Decrease	Fair	2 studies 42 participants
Delta-Tocopherol Glucoside + Glycylglycine Oleamide + Retinal	D	Slight Decrease	Some	2 studies 91 participants
Gluconolactone	D	Slight Decrease	Some	1 study 57 participants
Adapalene	D	Potential Decrease	Some	1 study 42 participants
Retinal	D	Potential Decrease	Good	1 study 85 participants
Alpha-Ketoglutarate	D	Potential Decrease	Some	1 study 30 participants
SIG-1273	D	Potential Decrease	Some	1 study 29 participants
Kinetin	D	Potential Decrease	Fair	2 studies 117 participants
Lactic Acid	D	Potential Decrease	Some	1 study 6 participants
Pterostilbene	D	Potential Decrease	Some	1 study 38 participants
Ascorbic Acid + Tetrahexyldecyl Ascorbate	D	Potential Decrease	Some	1 study 10 participants
Tretinoin	D	Potential Decrease	Good	4 studies 469 participants
Hyaluronic Acid + Retinal	D	Potential Decrease	Some	1 study 1175 participants
Kinetin + Niacinamide	D	Potential Decrease	Fair	1 study 27 participants
Rice Ceramides	D	Potential Decrease	Some	1 study 50 participants
Ammonium Lactate	E	No Effect	Some	1 study 21 participants

Products

Show 22 more products
Product	Grade	Effect	Evidence	Studies
RoC Retinol Correxion Deep Wrinkle Night Cream	C	Marked Decrease	Fair	1 study 36 participants
Imedeen Prime Renewal	C	Slight Decrease	Fair	1 study 80 participants
Imedeen	C	Slight Decrease	Fair	4 studies 177 participants
Boots No7 Protect & Perfect Intense Beauty Serum	C	Slight Decrease	Fair	1 study 60 participants
Cellex-C High-Potency Serum	C	Slight Decrease	Fair	1 study 19 participants
Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin	C	Slight Decrease	Fair	1 study 37 participants
Renova	C	Slight Decrease	Fair	2 studies 354 participants
Purpose Daily Use UV Moisturiser + Tretinoin	C	Slight Decrease	Fair	1 study 37 participants
Vivida	C	Slight Decrease	Fair	1 study 30 participants
Avene A-OXitive NIGHT Peeling Cream	D	Slight Decrease	Some	2 studies 91 participants
Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment	D	Slight Decrease	Some	1 study 187 participants
Avene Ystheal Anti-Wrinkle Cream	D	Potential Decrease	Good	1 study 85 participants
Komecera	D	Potential Decrease	Some	1 study 50 participants
Retin-A	D	Potential Decrease	Good	2 studies 115 participants
Neora Age IQ Night Cream	D	Potential Decrease	Some	1 study 37 participants
La Roche-Posay Active C	D	Potential Decrease	Fair	1 study 19 participants
Avene Eluage Anti-Wrinkle Concentrate	D	Potential Decrease	Some	1 study 177 participants
PteroWhite	D	Potential Decrease	Some	1 study 38 participants
Avene Eluage Cream + Avene Eluage Anti-Wrinkle Concentrate	D	Potential Decrease	Some	1 study 998 participants
Revision Skincare Retinol Complete + Revision Skincare Vitamin C Lotion 30%	D	Potential Decrease	Some	1 study 44 participants
Kinerase	D	Potential Decrease	Fair	2 studies 117 participants
ISDIN FotoUltra 100 Spot Prevent Fusion Fluid + Isdinceutics Pigment Expert	D	Potential Decrease	Some	1 study 11 participants
Isdinceutics Melatonik	D	Potential Decrease	Fair	2 studies 63 participants
Imedeen Time Perfection	D	Potential Decrease	Fair	3 studies 287 participants
Lac-Hydrin	E	No Effect	Some	1 study 21 participants
Imedeen Derma One	E	No Effect	Fair	1 study 150 participants
Imedeen Man-Age-Ment	E	No Effect	Some	1 study 41 participants

Treatments

Coming soon.

Skincare treatments can penetrate more deeply into the skin to provide faster, more dramatic and longer-lasting results than topical products, but they are also much more expensive.

Review all of the scientific evidence before spending thousands of dollars on treatments that won't work, or that make your skin worse due to the side effects.

Log in to register your interest in knowing when information on skincare treatments becomes available on Wisderm.com, and get a 20% discount on launch!

3 Studies Found

Intervention	Niacinamide
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	52

Intervention	Niacinamide
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	30

Intervention	Niacinamide
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	50

1 Study Found

Intervention	Bakuchiol
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	44

4 Studies Found

Intervention	Retinol
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	64

Intervention	Retinol
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	182 days
Participants	106

Intervention	Retinol
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	36

Intervention	Retinol
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	44

1 Study Found

Intervention	Niacinamide + Sericin + Signaline
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	30

2 Studies Found

Intervention	Glycolic Acid
Concern	Wrinkles
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	57

Intervention	Glycolic Acid
Concern	Wrinkles
Subject Type	Human
Trial Design	Non-Randomised Controlled
Trial Duration	42 days
Participants	10

2 Studies Found

Intervention	Ascorbic Acid
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	20

Intervention	Ascorbic Acid
Concern	Wrinkles
Subject Type	Human
Trial Design	Randomised Controlled
Trial Duration	84 days
Participants	75

2 Studies Found

Intervention	Delta-Tocopherol Glucoside + Glycylglycine Oleamide + Retinal
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	56 days
Participants	36

Intervention	Delta-Tocopherol Glucoside + Glycylglycine Oleamide + Retinal
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	57

1 Study Found

Intervention	Gluconolactone
Concern	Wrinkles
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	57

1 Study Found

Intervention	Adapalene
Concern	Wrinkles
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	252 days
Participants	90

1 Study Found

Intervention	Retinal
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	308 days
Participants	135

1 Study Found

Intervention	Alpha-Ketoglutarate
Concern	Wrinkles
Subject Type	Human
Trial Design	Non-Randomised Controlled
Trial Duration	56 days
Participants	30

1 Study Found

Intervention	SIG-1273
Concern	Wrinkles
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	28 days
Participants	31

2 Studies Found

Intervention	Kinetin
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	18

Intervention	Kinetin
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	100

1 Study Found

Intervention	Lactic Acid
Concern	Wrinkles
Subject Type	Human
Trial Design	Non-Randomised Controlled
Trial Duration	42 days
Participants	10

1 Study Found

Intervention	Pterostilbene
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Ascorbic Acid + Tetrahexyldecyl Ascorbate
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	10

4 Studies Found

Intervention	Tretinoin
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

Intervention	Tretinoin
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	308 days
Participants	135

Intervention	Tretinoin
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	40

Intervention	Tretinoin
Concern	Wrinkles
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	196

1 Study Found

Intervention	Hyaluronic Acid + Retinal
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	90 days
Participants	1462

1 Study Found

Intervention	Kinetin + Niacinamide
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	52

1 Study Found

Intervention	Rice Ceramides
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	50

1 Study Found

Intervention	Ammonium Lactate
Concern	Wrinkles
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	56 days
Participants	21

1 Study Found

Intervention	RoC Retinol Correxion Deep Wrinkle Night Cream
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	64

1 Study Found

Intervention	Imedeen Prime Renewal
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	100

4 Studies Found

Intervention	Imedeen
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Randomised Uncontrolled
Trial Duration	336 days
Participants	144

Intervention	Imedeen
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Participants	30

Intervention	Imedeen
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	90 days
Participants	40

Intervention	Imedeen
Concern	Wrinkles
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	90 days
Participants	6

1 Study Found

Intervention	Boots No7 Protect & Perfect Intense Beauty Serum
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	365 days
Participants	70

1 Study Found

Intervention	Cellex-C High-Potency Serum
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	28

1 Study Found

Intervention	Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

2 Studies Found

Intervention	Renova
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

Intervention	Renova
Concern	Wrinkles
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	196

1 Study Found

Intervention	Purpose Daily Use UV Moisturiser + Tretinoin
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

1 Study Found

Intervention	Vivida
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Participants	30

2 Studies Found

Intervention	Avene A-OXitive NIGHT Peeling Cream
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	56 days
Participants	36

Intervention	Avene A-OXitive NIGHT Peeling Cream
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	57

1 Study Found

Intervention	Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment
Concern	Wrinkles
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	196

1 Study Found

Intervention	Avene Ystheal Anti-Wrinkle Cream
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	308 days
Participants	135

1 Study Found

Intervention	Komecera
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	50

2 Studies Found

Intervention	Retin-A
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	308 days
Participants	135

Intervention	Retin-A
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	40

1 Study Found

Intervention	Neora Age IQ Night Cream
Concern	Wrinkles
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	La Roche-Posay Active C
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	20

1 Study Found

Intervention	Avene Eluage Anti-Wrinkle Concentrate
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	90 days
Participants	1462

1 Study Found

Intervention	PteroWhite
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Avene Eluage Cream + Avene Eluage Anti-Wrinkle Concentrate
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	90 days
Participants	1462

1 Study Found

Intervention	Revision Skincare Retinol Complete + Revision Skincare Vitamin C Lotion 30%
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	44

2 Studies Found

Intervention	Kinerase
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	18

Intervention	Kinerase
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	100

1 Study Found

Intervention	ISDIN FotoUltra 100 Spot Prevent Fusion Fluid + Isdinceutics Pigment Expert
Concern	Wrinkles
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	12

2 Studies Found

Intervention	Isdinceutics Melatonik
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	168 days
Participants	24

Intervention	Isdinceutics Melatonik
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	103

3 Studies Found

Intervention	Imedeen Time Perfection
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	91

Intervention	Imedeen Time Perfection
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	120 days
Participants	50

Intervention	Imedeen Time Perfection
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	194

1 Study Found

Intervention	Lac-Hydrin
Concern	Wrinkles
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	56 days
Participants	21

1 Study Found

Intervention	Imedeen Derma One
Concern	Wrinkles
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	201

1 Study Found

Intervention	Imedeen Man-Age-Ment
Concern	Wrinkles
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	210 days
Participants	47

Latest Research

Coming soon.

3 Studies Found

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial

Evaluation of anti-wrinkle effects of a novel cosmetic containing niacinamide

Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin

1 Study Found

Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing

4 Studies Found

One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial

Improvement of photoaged facial skin in middle-aged Japanese females by topical retinol (vitamin A alcohol): a vehicle-controlled, double-blind study

Improvement of naturally aged skin with vitamin A (retinol)

Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing

1 Study Found

Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing

2 Studies Found

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen

Comparative effectiveness of alpha-hydroxy acids on skin properties

2 Studies Found

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo

Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy

2 Studies Found

A new dermocosmetic containing retinaldehyde, delta-tocopherol glucoside and glycylglycine oleamide for managing naturally aged skin: results from in vitro to clinical studies

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study

1 Study Found

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen

1 Study Found

Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial

1 Study Found

Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment

1 Study Found

The study of skin hydration, anti-wrinkles function improvement of anti-aging cream with alpha-ketoglutarate

1 Study Found

In vitro and clinical evaluation of SIG1273: a cosmetic functional ingredient with a broad spectrum of anti-aging and antioxidant activities

2 Studies Found

Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea

Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin

1 Study Found

Comparative effectiveness of alpha-hydroxy acids on skin properties

1 Study Found

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects

1 Study Found

Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage

4 Studies Found

Topical tretinoin for treatment of photodamaged skin. A multicenter study

Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen

1 Study Found

Retinaldehyde/hyaluronic acid fragments: a synergistic association for the management of skin aging

1 Study Found

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial

1 Study Found

Effect of Rice ( Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study

1 Study Found

Use of alpha-hydroxy acids in the therapy for 'photoaged' skin

1 Study Found

One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial

1 Study Found

Effect of a novel dietary supplement on skin aging in post-menopausal women

4 Studies Found

Imedeen in the treatment of photoaged skin: an efficacy and safety trial over 12 months

Natural cartilage polysaccharides for the treatment of sun-damaged skin in females: a double-blind comparison of Vivida and Imedeen

Imedeen for the treatment of degenerated skin in females

An oral approach to the treatment of photodamaged skin: a pilot study

1 Study Found

Effects of a cosmetic 'anti-ageing' product on photoaged skin

1 Study Found

Use of topical ascorbic acid and its effects on photodamaged skin topography

1 Study Found

Facilitating facial retinization through barrier improvement

2 Studies Found

Topical tretinoin for treatment of photodamaged skin. A multicenter study

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen

1 Study Found

Facilitating facial retinization through barrier improvement

1 Study Found

Natural cartilage polysaccharides for the treatment of sun-damaged skin in females: a double-blind comparison of Vivida and Imedeen

2 Studies Found

A new dermocosmetic containing retinaldehyde, delta-tocopherol glucoside and glycylglycine oleamide for managing naturally aged skin: results from in vitro to clinical studies