Melasma

Efficacy and tolerability of a depigmenting gel serum comprising tranexamic acid, niacinamide, 4-butylresorcinol, phytic acid, and a mixture of hydroxy acids that targets the biological processes regulating skin melanogenesis (2024)

Efficacy and safety of a novel triple combination cream compared to Kligman's trio for melasma: A 24-week double-blind prospective randomized controlled trial (2023)

A Multi-Center, Randomized, Blinded Clinical Study Evaluating the Efficacy and Safety of a Novel Topical Product for Facial Dyschromia (2023)

A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas (2022)

Safety and efficacy of topical metformin 30% cream versus triple combination cream (Kligman's formula) in treating melasma: A randomized controlled study (2022)

An Open-Label Study Assessing the Efficacy and Tolerability of a Skincare Regimen in Subjects of Different Ethnicities with Moderate-to-Severe Hyperpigmentation (2022)

An open-label, investigator-initiated, single-center, prospective, pilot clinical study to evaluate the efficacy of a skin whitening serum applied twice daily combined with a spot-preventing SPF50+ sunscreen in healthy female subjects with melasma hyperpigmentation (2022)

Thiamidol® in moderate-to-severe melasma: 24-week, randomized, double-blind, vehicle-controlled clinical study with subsequent regression phase (2021)

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial (2021)

Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial (2021)

French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial (2021)

Evaluation of the efficacy of cysteamine cream compared to hydroquinone in the treatment of melasma: A randomised, double-blinded trial (2021)

Effective lightening of facial melasma during the summer with a dual regimen: A prospective, open-label, evaluator-blinded study (2020)

A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women (2020)

Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study (2020)

Topical metformin in the treatment of melasma: A preliminary clinical trial (2020)

Topical tranexamic acid versus hydroquinone for patients presenting with melasma (2019)

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma (2019)

Evaluation of the safety and efficacy of a triple combination cream (hydroquinone, tretinoin, and fluocinolone) for treatment of melasma in Middle Eastern skin (2019)

Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation (2019)

Topical silymarin versus hydroquinone in the treatment of melasma: A comparative study (2019)

A Randomized Controlled Study Comparing the Efficacy of Topical 5% Tranexamic Acid Solution versus 3% Hydroquinone Cream in Melasma (2019)

Brightening and Improvement of Facial Skin Quality in Healthy Female Subjects With Moderate Hyperpigmentation or Dark Spots and Moderate Facial Aging (2018)

A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma (2018)

Efficacy of cysteamine cream in the treatment of epidermal melasma, evaluating by Dermacatch as a new measurement method: a randomized double blind placebo controlled study (2018)

Therapeutic Effects of Topical Tranexamic Acid in Comparison with Hydroquinone in Treatment of Women with Melasma (2017)

Clinical efficacy of liposome-encapsulated Aloe vera on melasma treatment during pregnancy (2017)

Efficacy and possible mechanisms of topical tranexamic acid in melasma (2016)

Assessment of efficacy, safety, and tolerability of 4-n-butylresorcinol 0.3% cream: an Indian multicentric study on melasma (2016)

A novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% for treatment of epidermal melasma (2015)

The use of pycnogenol in the treatment of melasma (2015)

Comparison of therapeutic effects of liposomal Tranexamic Acid and conventional Hydroquinone on melasma (2015)

Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double-blind placebo-controlled trial (2015)

Topical tranexamic acid as a promising treatment for melasma (2014)

A double-blind vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of melasma in females (2014)

Objective assessment of erythema and pigmentation of melasma lesions and surrounding areas in long-term management regimens with triple combination (2014)

Blockade of melanin synthesis, activation and distribution pathway by a nonprescription natural regimen is equally effective to a multiple prescription-based therapeutic regimen (2013)

Kojic Acid vis-a-vis its Combinations with Hydroquinone and Betamethasone Valerate in Melasma: A Randomized, Single Blind, Comparative Study of Efficacy and Safety (2013)

A Comparative Study of the Efficacy of 4% Hydroquinone vs 0.75% Kojic Acid Cream in the Treatment of Facial Melasma (2013)

The treatment of melasma by silymarin cream (2012)

Topical 5% tranexamic acid for the treatment of melasma in Asians: a double-blind randomized controlled clinical trial (2012)

Preventing melasma recurrence: prescribing a maintenance regimen with an effective triple combination cream based on long-standing clinical severity (2012)

Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma (2011)

Efficacy of a novel hydroquinone-free skin-brightening cream in patients with melasma (2011)

Continuous therapy followed by a maintenance therapy regimen with a triple combination cream for melasma (2010)

A histological examination for skin atrophy after 6 months of treatment with fluocinolone acetonide 0.01%, hydroquinone 4%, and tretinoin 0.05% cream (2009)

A randomized controlled trial of the efficacy and safety of a fixed triple combination (fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%) compared with hydroquinone 4% cream in Asian patients with moderate to severe melasma (2008)

Evaluation of efficacy and safety of rucinol serum in patients with melasma: a randomized controlled trial (2007)

A comparison of triple combination cream and hydroquinone 4% cream for the treatment of moderate to severe facial melasma (2007)

Tazarotene versus tazarotene plus hydroquinone in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized study (2006)

Whitening effect of a dermocosmetic formulation: a randomized double-blind controlled study on melasma (2006)

Community-based trial of a triple-combination agent for the treatment of facial melasma (2006)

Hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%: a safe and efficacious 12-month treatment for melasma (2005)

A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma (2004)

Efficacy and safety of a new triple-combination agent for the treatment of facial melasma (2003)

Treatment of melasma with Pycnogenol (2002)

Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid (1999)

The combination of glycolic acid and hydroquinone or kojic acid for the treatment of melasma and related conditions (1996)

Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo (1996)

Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial (1993)

The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream (1991)

Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma (1989)