Melasma

Ingredients

Show 7 more ingredients
Ingredient	Grade	Effect	Evidence	Studies
Tretinoin	C	Marked Decrease	Fair	1 study 38 participants
Cysteamine	C	Notable Decrease	Fair	4 studies 147 participants
Ascorbic Acid	C	Slight Decrease	Fair	1 study 16 participants
Hydroquinone	C	Slight Decrease	Fair	8 studies 549 participants
Thiamidol	C	Slight Decrease	Fair	2 studies 91 participants
Hyaluronic Acid	D	Slight Decrease	Some	1 study 60 participants
Hyaluronic Acid + Panthenol + Thiamidol	D	Slight Decrease	Some	1 study 47 participants
Triple Combination Cream	D	Slight Increase	Some	1 study 40 participants
Metformin	D	Slight Increase	Some	1 study 40 participants
Azelaic Acid	D	Slight Decrease	Some	3 studies 404 participants
Hyaluronic Acid + Thiamidol	D	Slight Decrease	Some	1 study 60 participants
Arbutin + Bisabolol + Niacinamide + Retinal	D	Potential Decrease	Some	1 study 33 participants

Products

Show 5 more products
Product	Grade	Effect	Evidence	Studies
Retin-A	C	Marked Decrease	Fair	1 study 38 participants
Esoterica	C	Slight Decrease	Fair	1 study 132 participants
Eucerin UltraWHITE Spotless Double Booster Serum	D	Slight Decrease	Some	1 study 60 participants
Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30	D	Slight Decrease	Some	1 study 34 participants
Eucerin Anti-Pigment Day SPF30	D	Slight Decrease	Some	1 study 34 participants
Dermage Clarite Cysteamin	D	Slight Decrease	Some	1 study 40 participants
Isdinceutics Melaclear	D	Potential Decrease	Some	1 study 10 participants
SkinCeuticals Discoloration Defense	D	Potential Decrease	Some	1 study 48 participants
ISDIN FotoUltra 100 Spot Prevent Fusion Fluid + Isdinceutics Pigment Expert	D	Potential Decrease	Some	1 study 11 participants
Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30 + Eucerin Anti-Pigment Night	D	Potential Decrease	Some	1 study 83 participants

Treatments

Coming soon.

Skincare treatments can penetrate more deeply into the skin to provide faster, more dramatic and longer-lasting results than topical products, but they are also much more expensive.

Review all of the scientific evidence before spending thousands of dollars on treatments that won't work, or that make your skin worse due to the side effects.

Log in to register your interest in knowing when information on skincare treatments becomes available on Wisderm.com, and get a 20% discount on launch!

1 Study Found

Intervention	Tretinoin
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	280 days
Participants	50

4 Studies Found

Intervention	Cysteamine
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	20

Intervention	Cysteamine
Concern	Melasma
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	120 days
Participants	40

Intervention	Cysteamine
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Participants	40

Intervention	Cysteamine
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	55

1 Study Found

Intervention	Ascorbic Acid
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	16

8 Studies Found

Intervention	Hydroquinone
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	80

Intervention	Hydroquinone
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	20

Intervention	Hydroquinone
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	155

Intervention	Hydroquinone
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	16

Intervention	Hydroquinone
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	329

Intervention	Hydroquinone
Concern	Melasma
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	30

Intervention	Hydroquinone
Concern	Melasma
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	120 days
Participants	40

Intervention	Hydroquinone
Concern	Melasma
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	90 days
Participants	50

2 Studies Found

Intervention	Thiamidol
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	80

Intervention	Thiamidol
Concern	Melasma
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

1 Study Found

Intervention	Hyaluronic Acid
Concern	Melasma
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

1 Study Found

Intervention	Hyaluronic Acid + Panthenol + Thiamidol
Concern	Melasma
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	90 days
Participants	50

1 Study Found

Intervention	Triple Combination Cream
Concern	Melasma
Subject Type	Human
Trial Design	Randomised Controlled
Trial Duration	56 days
Participants	40

1 Study Found

Intervention	Metformin
Concern	Melasma
Subject Type	Human
Trial Design	Randomised Controlled
Trial Duration	56 days
Participants	40

3 Studies Found

Intervention	Azelaic Acid
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	155

Intervention	Azelaic Acid
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	329

Intervention	Azelaic Acid
Concern	Melasma
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	30

1 Study Found

Intervention	Hyaluronic Acid + Thiamidol
Concern	Melasma
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

1 Study Found

Intervention	Arbutin + Bisabolol + Niacinamide + Retinal
Concern	Melasma
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	60 days
Participants	35

1 Study Found

Intervention	Retin-A
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	280 days
Participants	50

1 Study Found

Intervention	Esoterica
Concern	Melasma
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	155

1 Study Found

Intervention	Eucerin UltraWHITE Spotless Double Booster Serum
Concern	Melasma
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

1 Study Found

Intervention	Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30
Concern	Melasma
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	117

1 Study Found

Intervention	Eucerin Anti-Pigment Day SPF30
Concern	Melasma
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	117

1 Study Found

Intervention	Dermage Clarite Cysteamin
Concern	Melasma
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	120 days
Participants	40

1 Study Found

Intervention	Isdinceutics Melaclear
Concern	Melasma
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	10

1 Study Found

Intervention	SkinCeuticals Discoloration Defense
Concern	Melasma
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	55

1 Study Found

Intervention	ISDIN FotoUltra 100 Spot Prevent Fusion Fluid + Isdinceutics Pigment Expert
Concern	Melasma
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	12

1 Study Found

Intervention	Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30 + Eucerin Anti-Pigment Night
Concern	Melasma
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	117

Latest Research

Coming soon.

1 Study Found

Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial

4 Studies Found

Evaluation of the efficacy of cysteamine cream compared to hydroquinone in the treatment of melasma: A randomised, double-blinded trial

A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women

Efficacy of cysteamine cream in the treatment of epidermal melasma, evaluating by Dermacatch as a new measurement method: a randomized double blind placebo controlled study

Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double-blind placebo-controlled trial

1 Study Found

A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma

8 Studies Found

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma

Evaluation of the efficacy of cysteamine cream compared to hydroquinone in the treatment of melasma: A randomised, double-blinded trial

Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma

A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma

The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream

Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma

A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women

Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial

2 Studies Found

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

1 Study Found

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

1 Study Found

Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial

1 Study Found

Topical metformin in the treatment of melasma: A preliminary clinical trial

1 Study Found

Topical metformin in the treatment of melasma: A preliminary clinical trial

3 Studies Found

Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma

The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream

Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma

1 Study Found

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

1 Study Found

A novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% for treatment of epidermal melasma

1 Study Found

Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial

1 Study Found

Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma

1 Study Found

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

1 Study Found

Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study

1 Study Found

Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study

1 Study Found

A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women

1 Study Found

Brightening and Improvement of Facial Skin Quality in Healthy Female Subjects With Moderate Hyperpigmentation or Dark Spots and Moderate Facial Aging

1 Study Found

Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation

1 Study Found

An open-label, investigator-initiated, single-center, prospective, pilot clinical study to evaluate the efficacy of a skin whitening serum applied twice daily combined with a spot-preventing SPF50+ sunscreen in healthy female subjects with melasma hyperpigmentation

1 Study Found

Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study

An open-label, investigator-initiated, single-center, prospective, pilot clinical study to evaluate the efficacy of a skin whitening serum applied twice daily combined with a spot-preventing SPF50+ sunscreen in healthy female subjects with melasma hyperpigmentation (2022)

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial (2021)

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial (2021)

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial (2021)

Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial (2021)