Hydroquinone + Tretinoin + Corticosteroid + Maritime Pine Bark Extract Supplement

Efficacy

Outcome				Grade		Effect		Evidence		Studies
Melasma				A		🠫 Slight		★★★★ Good		1 study 44 participants
Hyperpigmentation				A		🠫 Slight		★★★★ Good		1 study 44 participants

Side Effects

Latest Research

French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial (2021)