Hyperpigmentation

A Multi-Center, Double-Blind, Randomized, Comparator Controlled Trial Evaluating Topical Formulations for Skin Fragility of the Arms (2024)

The Clinical Efficacy and Tolerability of a Novel Retinaldehyde Serum with Firming Peptides to Improve Skin Texture and Signs of Photoaging (2024)

A Novel Protection and Repair Skincare Regimen Shows Efficacy for Improving Environmental Skin Aging (2024)

Open-label topical application of tetrahexyldecyl ascorbate and acetyl zingerone containing serum improves the appearance of photoaging and uneven pigmentation (2024)

Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging (2024)

Topical application of retinyl propionate, 4 hexyl resorcinol, and niacinamide reverses molecular and clinical features of ageing (2024)

Efficacy and tolerability of a depigmenting gel serum comprising tranexamic acid, niacinamide, 4-butylresorcinol, phytic acid, and a mixture of hydroxy acids that targets the biological processes regulating skin melanogenesis (2024)

Efficacy of isobutylamido thiazolyl resorcinol for prevention of laser-induced post-inflammatory hyperpigmentation: A randomized, controlled trial (2024)

Effectiveness and tolerance of multicorrective topical treatment for infraorbital dark circles and puffiness (2024)

Multicenter evaluation of a topical antioxidant serum (2024)

Restoration of Aging Body Skin: Evidence-Based Development of a Topical Formulation for Improving Body Skin Quality (2023)

Prospective, randomized, double-blind clinical study of split-body comparison of topical hydroquinone and hexylresorcinol for skin pigment appearance (2023)

A Multi-Center, Randomized, Blinded Clinical Study Evaluating the Efficacy and Safety of a Novel Topical Product for Facial Dyschromia (2023)

Evaluation of a New, Advanced Antioxidant Containing Topical Allyl Pyrroloquinoline Quinone: Analysis of Antioxidant Properties and Visible Effects in Subjects with Facial Photodamage (2023)

A comparative study of 20% azelaic acid cream versus 5% tranexamic acid solution for the treatment of postinflammatory hyperpigmentation in patients with acne vulgaris: A single-blinded randomized clinical trial (2023)

Evaluation of the Reduction of Skin Hyperpigmentation Changes under the Influence of a Preparation Containing Kojic Acid Using Hyperspectral Imaging-Preliminary Study (2023)

Impact of defensins-containing body cream on skin composition (2023)

Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months-An 11-Year Longitudinal Skin Aging Rejuvenation Study (2023)

A Randomized, Double-Blind, Split-Face Study of Topical Silymarin vs 2% Hydroquinone Cream in Melasmas (2022)

An open-label, 4-week, prospective clinical study evaluating the efficacy and safety of a novel targeted skin care line addressing five common skin conditions (2022)

Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs (2022)

Efficacy and tolerability of a hyaluronic acid-based serum and a peptide-rich cream for the face and neck in subjects with photodamaged skin (2022)

Safety and efficacy of topical metformin 30% cream versus triple combination cream (Kligman's formula) in treating melasma: A randomized controlled study (2022)

An Open-Label Study Assessing the Efficacy and Tolerability of a Skincare Regimen in Subjects of Different Ethnicities with Moderate-to-Severe Hyperpigmentation (2022)

A Prospective, Randomized, Double-Blind, Vehicle-Controlled Study Evaluating the Efficacy, Safety, and Patient Satisfaction of Tretinoin 0.05% Lotion for Chest Rejuvenation (2022)

An open-label, investigator-initiated, single-center, prospective, pilot clinical study to evaluate the efficacy of a skin whitening serum applied twice daily combined with a spot-preventing SPF50+ sunscreen in healthy female subjects with melasma hyperpigmentation (2022)

Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide (2022)

A dermocosmetic formulation containing Vichy volcanic mineralizing water, Vitreoscilla filiformis extract, niacinamide, hyaluronic acid, and vitamin E regenerates and repairs acutely stressed skin (2022)

Thiamidol® in moderate-to-severe melasma: 24-week, randomized, double-blind, vehicle-controlled clinical study with subsequent regression phase (2021)

Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial (2021)

Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study (2021)

Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol) (2021)

A Randomized, Double-Blind, Split-Body, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Tolerability of a Topical Body Firming Moisturizer for Upper Arm Rejuvenation (2021)

A Clinical Study Evaluating the Efficacy of Topical Bakuchiol (UP256) Cream on Facial Acne (2021)

Isobutylamido thiazolyl resorcinol for prevention of UVB-induced hyperpigmentation (2021)

Efficacy of topical antioxidants in the skin hyperpigmentation control: A clinical study by reflectance confocal microscopy (2021)

Efficacy and Tolerability of a Novel Topical Treatment for Neck: A Randomized, Double-blind, Regimen-Controlled Study (2021)

French maritime pine bark extract (pycnogenol) in association with triple combination cream for the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled trial (2021)

Randomized double-blind vehicle controlled study of the effects of topical acetyl zingerone on photoaging (2021)

Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin (2020)

A novel skin brightening topical technology (2020)

A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women (2020)

Night Cream Containing Melatonin, Carnosine and Helichrysum italicum Extract Helps Reduce Skin Reactivity and Signs of Photodamage: Ex Vivo and Clinical Studies (2020)

Clinical Benefits of Circadian-based Antioxidant Protection and Repair (2020)

Amazake made from sake cake and rice koji suppresses sebum content in differentiated hamster sebocytes and improves skin properties in humans (2020)

Effect of defensins-containing eye cream on periocular rhytids and skin quality (2020)

Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study (2020)

Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis (2020)

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects (2020)

Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals (2019)

SIG-1273 protects skin against urban air pollution and when formulated in AgeIQ™ Night Cream anti-aging benefits clinically demonstrated (2019)

Long-term objective assessments of skin rejuvenation using solar protection and solar repair shown through digital facial surface analysis and three-dimensional volumetric assessment (2019)

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma (2019)

Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days (2019)

Evaluation of the safety and efficacy of a triple combination cream (hydroquinone, tretinoin, and fluocinolone) for treatment of melasma in Middle Eastern skin (2019)

Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation (2019)

Evaluation of the Antioxidant Capacity and Protective Effects of a Comprehensive Topical Antioxidant Containing Water-soluble, Enzymatic, and Lipid-soluble Antioxidants (2019)

Whitening effect of L-ascorbate-2-phosphate trisodium salt on solar lentigos (2019)

Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing (2019)

Brightening and Improvement of Facial Skin Quality in Healthy Female Subjects With Moderate Hyperpigmentation or Dark Spots and Moderate Facial Aging (2018)

Topical Growth Factors for the Treatment of Facial Photoaging: A Clinical Experience of Eight Cases (2018)

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study (2018)

Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase (2018)

Comparable efficacy of adapalene 0.3% gel and tretinoin 0.05% cream as treatment for cutaneous photoaging (2018)

Efficacy of cysteamine cream in the treatment of epidermal melasma, evaluating by Dermacatch as a new measurement method: a randomized double blind placebo controlled study (2018)

Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation (2017)

Efficacy and tolerability of a double-conjugated retinoid cream vs 1.0% retinol cream or 0.025% tretinoin cream in subjects with mild to severe photoaging (2017)

Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study (2017)

Therapeutic Effects of Topical Tranexamic Acid in Comparison with Hydroquinone in Treatment of Women with Melasma (2017)

Assessment of the efficacy and safety of a new complex skin cream in Asian women: A controlled clinical trial (2017)

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women (2017)

Clinical effects of an oral supplement rich in antioxidants on skin radiance in women (2016)

Efficacy and possible mechanisms of topical tranexamic acid in melasma (2016)

Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol (2016)

A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females (2016)

An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol and Vitamin C Facial Regimen in Women With Mild-to-Moderate Hyperpigmentation and Photodamaged Facial Skin (2016)

A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating an Oral Anti-aging Skin Care Supplement for Treating Photodamaged Skin (2016)

Assessment of a Novel Anti-Aging Hand Cream (2016)

A placebo-controlled, double-blind clinical trial to evaluate the efficacy of Imedeen Time Perfection for improving the appearance of photodamaged skin (2016)

Superior Efficacy of an Herbal-based Cosmeceutical Compared With Common Prescription and Cosmetic Antiaging Therapies (2016)

Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing (2015)

A novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% for treatment of epidermal melasma (2015)

Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin (2015)

Facial primer provides immediate and long-term improvements in mild-to-moderate facial hyperpigmentation and fine lines associated with photoaging (2015)

Long-term Multi-product Facial Regimen in Subjects with Moderate-to-severe Photodamage and Hyperpigmentation (2015)

4-Hexyl-1,3-phenylenediol, a nuclear factor-κB inhibitor, improves photodamaged skin and clinical signs of ageing in a double-blinded, randomized controlled trial (2015)

An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin (2015)

Total Defense + Repair: A Novel Concept in Solar Protection and Skin Rejuvenation (2015)

Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double-blind placebo-controlled trial (2015)

Pilot Study of Topical Copper Chlorophyllin Complex in Subjects With Facial Acne and Large Pores (2015)

Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men (2015)

Assessment of the safety and efficacy of topical copper chlorophyllin in women with photodamaged facial skin (2015)

A double-blind randomized study comparing the association of Retinol and LR2412 with tretinoin 0.025% in photoaged skin (2015)

One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial (2015)

A randomized, double-blind, split-face study comparing the efficacy and tolerability of three retinol-based products vs. three tretinoin-based products in subjects with moderate to severe facial photodamage (2015)

Evaluation of a novel anti-aging topical formulation containing cycloastragenol, growth factors, peptides, and antioxidants (2014)

Clinical efficacy and safety of 4-hexyl-1,3-phenylenediol for improving skin hyperpigmentation (2014)

A single center, pilot, double-blinded, randomized, comparative, prospective clinical study to evaluate improvements in the structure and function of facial skin with tazarotene 0.1% cream alone and in combination with GliSODin(®) Skin Nutrients Advanced Anti-Aging Formula (2014)

Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial (2014)

Hydroquinone-free Skin Brightener System for the Treatment of Moderate-to-severe Facial Hyperpigmentation (2014)

Objective assessment of erythema and pigmentation of melasma lesions and surrounding areas in long-term management regimens with triple combination (2014)

Effects of Resveratrol and Collagen Supplementation on Facial Aging (2014)

Blockade of melanin synthesis, activation and distribution pathway by a nonprescription natural regimen is equally effective to a multiple prescription-based therapeutic regimen (2013)

Efficacy and safety of adapalene gel 0.1% and 0.3% and tretinoin gel 0.05% for acne vulgaris: results of a single-center, randomized, double-blinded, placebo-controlled clinical trial on Mexican patients (skin type III-IV) (2013)

Efficacy of a novel treatment serum in the improvement of photodamaged skin (2013)

The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites (2013)

Efficacy of hydroquinone-free skin-lightening cream for photoaging (2013)

4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation (2013)

Clinical efficacy and safety of a multimodality skin brightener composition compared with 4% hydroquinone (2012)

The treatment of melasma by silymarin cream (2012)

Clinical effects of collagen hydrolysates ingestion on UV-induced pigmented spots of human skin: A preliminary study (2012)

Improved texture and appearance of human facial skin after daily topical application of barley produced, synthetic, human-like epidermal growth factor (EGF) serum (2012)

Instrumental and clinical studies of the facial skin tone and pigmentation of Shanghaiese women. Changes induced by age and a cosmetic whitening product (2012)

Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin (2012)

Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma (2011)

Salicin regulates the expression of functional 'youth gene clusters' to reflect a more youthful gene expression profile (2011)

Efficacy of a novel hydroquinone-free skin-brightening cream in patients with melasma (2011)

Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study (2011)

Analytic assessment under ultraviolet light of actinic lentigines under bleaching treatment (2011)

Retinaldehyde/hyaluronic acid fragments: a synergistic association for the management of skin aging (2011)

An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging (2010)

Evaluation of a kojic acid, emblica extract, and glycolic acid formulation compared with hydroquinone 4% for skin lightening (2010)

A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines (2010)

Continuous therapy followed by a maintenance therapy regimen with a triple combination cream for melasma (2010)

Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial (2010)

Combination of physiologically balanced growth factors with antioxidants for reversal of facial photodamage (2010)

Pigmented contact dermatitis due to kojic acid. A paradoxical side effect of a skin lightener (2010)

Reduction in the appearance of facial hyperpigmentation by topical N-undecyl-10-enoyl-L-phenylalanine and its combination with niacinamide (2009)

An oral nutraceutical containing antioxidants, minerals and glycosaminoglycans improves skin roughness and fine wrinkles (2009)

Clinical Safety and Efficacy in Photoaged Skin With CoffeeBerry Extract, a Natural Antioxidant (2009)

Effects of a cosmetic 'anti-ageing' product on photoaged skin (2009)

A two-year, double-blind, randomized placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histologic appearance of photoaging skin (2009)

Improvement of photoaged facial skin in middle-aged Japanese females by topical retinol (vitamin A alcohol): a vehicle-controlled, double-blind study (2009)

Anti-Aging Effects and Tolerability of High Strength Hydroxy Acids in Males with Moderate to Severe Photoaging (2009)

Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin (2008)

Antiaging Effects of Topical Lactobionic Acid: Results of A Controlled Usage Study (2008)

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial (2007)

Topical manganese peptide in the treatment of photodamaged skin (2007)

Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea (2007)

Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage (2007)

Efficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study (2007)

Evaluation of efficacy and safety of rucinol serum in patients with melasma: a randomized controlled trial (2007)

Efficacy and tolerability of kinetin 0.1% cream for improving the signs of photoaging in facial and neck skin (2006)

Facilitating facial retinization through barrier improvement (2006)

Effect of a novel dietary supplement on skin aging in post-menopausal women (2006)

Tazarotene versus tazarotene plus hydroquinone in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized study (2006)

Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled study (2006)

Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging (2005)

Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible (2005)

Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin (2005)

Long-term efficacy and safety of tretinoin emollient cream 0.05% in the treatment of photodamaged facial skin: a two-year, randomized, placebo-controlled trial (2005)

A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage (2005)

Hydroquinone 4%, tretinoin 0.05%, fluocinolone acetonide 0.01%: a safe and efficacious 12-month treatment for melasma (2005)

Histological effects of tazarotene 0.1% cream vs. vehicle on photodamaged skin: a 6-month, multicentre, double-blind, randomized, vehicle-controlled study in patients with photodamaged facial skin (2004)

Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin (2004)

A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma (2004)

The use of polyhydroxy acids (PHAs) in photoaged skin (2004)

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen (2004)

Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin (2003)

Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial (2003)

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo (2003)

The effects of an estrogen and glycolic acid cream on the facial skin of postmenopausal women: a randomized histologic study (2003)

Efficacy of 0.1% tazarotene cream for the treatment of photodamage: a 12-month multicenter, randomized trial (2002)

Clinical study of safety and efficacy of using topical kinetin 0.1% (Kinerase®) to treat photodamaged skin (2002)

The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer (2002)

Utilization of a high-resolution digital imaging system for the objective and quantitative assessment of hyperpigmented spots on the face (2002)

Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage (2002)

Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks (2001)

Photodamage pilot study: a double-blind, vehicle-controlled study to assess the efficacy and safety of tazarotene 0.1% gel (2000)

Use of topical ascorbic acid and its effects on photodamaged skin topography (1999)

Comparative effects of retinoic acid, glycolic acid and a lipophilic derivative of salicylic acid on photodamaged epidermis (1999)

Imedeen in the treatment of photoaged skin: an efficacy and safety trial over 12 months (1998)

Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients (1998)

A clinicopathological study of the effects of topical retinyl propionate cream in skin photoageing (1998)

A double-blind randomized clinical trial on the effectiveness of a daily glycolic acid 5% formulation in the treatment of photoaging (1998)

Treatment of skin aging with topical estrogens (1996)

Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind vehicle-controlled clinical trial (1996)

Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo (1996)

Treatment of skin ageing symptoms in perimenopausal females with estrogen compounds. A pilot study (1994)

Topical tretinoin (retinoic acid) treatment of hyperpigmented lesions associated with photoaging in Chinese and Japanese patients: a vehicle-controlled trial (1994)

Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial (1993)

Tretinoin emollient cream 0.01% for the treatment of photoaged skin (1993)

Natural cartilage polysaccharides for the treatment of sun-damaged skin in females: a double-blind comparison of Vivida and Imedeen (1992)

An oral approach to the treatment of photodamaged skin: a pilot study (1992)

Tretinoin emollient cream: a new therapy for photodamaged skin (1992)

Topical tretinoin (retinoic acid) treatment for liver spots associated with photodamage (1992)

The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream (1991)

Topical tretinoin for treatment of photodamaged skin. A multicenter study (1991)

Imedeen for the treatment of degenerated skin in females (1991)

Use of alpha-hydroxy acids in the therapy for 'photoaged' skin (1990)

Sustained improvement with prolonged topical tretinoin (retinoic acid) for photoaged skin (1990)

Treatment of photodamaged facial skin with topical tretinoin (1989)

Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma (1989)

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study (1988)