Hyperpigmentation

Ingredients

Show 24 more ingredients
Ingredient	Grade	Effect	Evidence	Studies
Hydroquinone	C	Marked Decrease	Fair	8 studies 680 participants
Ascorbic Acid	C	Marked Decrease	Fair	2 studies 35 participants
Cysteamine	C	Marked Decrease	Fair	3 studies 178 participants
Azelaic Acid	C	Marked Decrease	Fair	5 studies 560 participants
Niacinamide + Tranexamic Acid	C	Marked Decrease	Fair	1 study 42 participants
Niacinamide	C	Slight Decrease	Fair	5 studies 271 participants
Retinol	C	Slight Decrease	Fair	3 studies 134 participants
Tretinoin	C	Slight Decrease	Fair	4 studies 278 participants
Bakuchiol	C	Slight Decrease	Fair	1 study 44 participants
N-Acetyl Glucosamine + Niacinamide	C	Slight Decrease	Fair	1 study 188 participants
Niacinamide + Sericin + Signaline	C	Slight Decrease	Fair	1 study 30 participants
Thiamidol	C	Slight Decrease	Fair	3 studies 139 participants
Niacinamide + Sepiwhite	C	Slight Decrease	Fair	1 study 100 participants
Arbutin + Galactomyces Ferment Filtrate + Niacinamide + Tranexamic Acid	D	Marked Decrease	Some	1 study 44 participants
Hyaluronic Acid + Panthenol + Thiamidol	D	Marked Decrease	Some	1 study 47 participants
Hyaluronic Acid + Thiamidol	D	Notable Decrease	Some	1 study 30 participants
Adapalene	D	Slight Decrease	Some	2 studies 167 participants
Gluconolactone	D	Slight Decrease	Some	1 study 57 participants
Glycolic Acid	D	Slight Decrease	Some	1 study 57 participants
Delta-Tocopherol Glucoside + Glycylglycine Oleamide + Retinal	D	Slight Decrease	Some	1 study 57 participants
Kinetin	D	Potential Decrease	Fair	2 studies 117 participants
Hyaluronic Acid + Retinal	D	Potential Decrease	Some	1 study 2250 participants
Gluconolactone + Glycolic Acid + Lactobionic Acid	D	Potential Decrease	Some	1 study 29 participants
Ascorbic Acid + Tetrahexyldecyl Ascorbate	D	Potential Decrease	Some	1 study 10 participants
Kinetin + Niacinamide	D	Potential Decrease	Fair	1 study 27 participants
Linoleic Acid + Niacinamide + Oxidised Glutathione + Oxyresveratrol + Tranexamic Acid	D	Potential Decrease	Some	1 study 52 participants
Ammonium Lactate	E	No Effect	Some	1 study 21 participants
Arbutin + Bisabolol + Niacinamide + Retinal	E	No Effect	Some	1 study 33 participants
Pterostilbene	E	No Effect	Some	1 study 38 participants

Products

Show 31 more products
Product	Grade	Effect	Evidence	Studies
Esoterica	C	Marked Decrease	Fair	1 study 155 participants
Aestura Regederm RX White Project	C	Marked Decrease	Fair	1 study 42 participants
Purpose Daily Use UV Moisturiser + Tretinoin	C	Slight Decrease	Fair	1 study 37 participants
Renova	C	Slight Decrease	Fair	1 study 167 participants
RoC Retinol Correxion Deep Wrinkle Night Cream	C	Slight Decrease	Fair	1 study 36 participants
Retin-A	C	Slight Decrease	Fair	3 studies 111 participants
Imedeen	C	Slight Decrease	Fair	5 studies 256 participants
Imedeen Time Perfection	C	Slight Decrease	Fair	3 studies 287 participants
Vivida	C	Slight Decrease	Fair	1 study 30 participants
Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin	C	Slight Decrease	Fair	1 study 37 participants
Dermage Clarite Cysteamin	D	Marked Decrease	Some	1 study 40 participants
Eucerin UltraWHITE Spotless Double Booster Serum	D	Notable Decrease	Some	1 study 30 participants
Eucerin Anti-Pigment Day SPF30	D	Slight Decrease	Some	1 study 34 participants
Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30	D	Slight Decrease	Some	1 study 34 participants
Avene A-OXitive NIGHT Peeling Cream	D	Slight Decrease	Some	1 study 57 participants
Finacea	D	Potential Decrease	Some	1 study 20 participants
Isdinceutics Melaclear	D	Potential Decrease	Some	1 study 10 participants
SkinAx²	D	Potential Decrease	Some	1 study 35 participants
Kinerase	D	Potential Decrease	Fair	2 studies 117 participants
Neora Age IQ Night Cream	D	Potential Decrease	Some	1 study 37 participants
SkinCeuticals Discoloration Defense	D	Potential Decrease	Some	1 study 55 participants
Avene Eluage Cream + Avene Eluage Anti-Wrinkle Concentrate	D	Potential Decrease	Some	1 study 1004 participants
La Roche-Posay Active C	D	Potential Decrease	Fair	1 study 19 participants
Isdinceutics Melatonik	D	Potential Decrease	Fair	2 studies 63 participants
ISDIN FotoUltra 100 Spot Prevent Fusion Fluid + Isdinceutics Pigment Expert	D	Potential Decrease	Some	1 study 11 participants
Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30 + Eucerin Anti-Pigment Night	D	Potential Decrease	Fair	2 studies 112 participants
Revision Skincare Retinol Complete + Revision Skincare Vitamin C Lotion 30%	D	Potential Decrease	Some	1 study 44 participants
Imedeen Derma One	D	Potential Decrease	Fair	1 study 152 participants
Imedeen Man-Age-Ment	D	Potential Decrease	Some	1 study 41 participants
Avene Eluage Anti-Wrinkle Concentrate	D	Potential Decrease	Some	1 study 1004 participants
Cellex-C High-Potency Serum	D	Potential Decrease	Fair	1 study 19 participants
Avene Eluage Cream	D	Potential Decrease	Some	1 study 242 participants
Burt's Bees Renewal Refining Cleanser + Burt's Bees Renewal Moisturizing Cream	D	Potential Decrease	Some	1 study 60 participants
PteroWhite	E	No Effect	Some	1 study 38 participants
Lac-Hydrin	E	No Effect	Some	1 study 21 participants
Boots No7 Protect & Perfect Intense Beauty Serum	E	No Effect	Fair	1 study 60 participants

Treatments

Coming soon.

Skincare treatments can penetrate more deeply into the skin to provide faster, more dramatic and longer-lasting results than topical products, but they are also much more expensive.

Review all of the scientific evidence before spending thousands of dollars on treatments that won't work, or that make your skin worse due to the side effects.

Log in to register your interest in knowing when information on skincare treatments becomes available on Wisderm.com, and get a 20% discount on launch!

8 Studies Found

Intervention	Hydroquinone
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Randomised Controlled
Trial Duration	28 days
Participants	44

Intervention	Hydroquinone
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	80

Intervention	Hydroquinone
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	155

Intervention	Hydroquinone
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	16

Intervention	Hydroquinone
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	329

Intervention	Hydroquinone
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	30

Intervention	Hydroquinone
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	120 days
Participants	40

Intervention	Hydroquinone
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	90 days
Participants	50

2 Studies Found

Intervention	Ascorbic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	20

Intervention	Ascorbic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	16

3 Studies Found

Intervention	Cysteamine
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	120 days
Participants	40

Intervention	Cysteamine
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Participants	40

Intervention	Cysteamine
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	55

5 Studies Found

Intervention	Azelaic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	155

Intervention	Azelaic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	329

Intervention	Azelaic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	30

Intervention	Azelaic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	112 days
Participants	20

Intervention	Azelaic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	52

1 Study Found

Intervention	Niacinamide + Tranexamic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	42

5 Studies Found

Intervention	Niacinamide
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	232

Intervention	Niacinamide
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	138

Intervention	Niacinamide
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	52

Intervention	Niacinamide
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	294 days
Participants	79

Intervention	Niacinamide
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	50

3 Studies Found

Intervention	Retinol
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	64

Intervention	Retinol
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	182 days
Participants	106

Intervention	Retinol
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	44

4 Studies Found

Intervention	Tretinoin
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

Intervention	Tretinoin
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	40

Intervention	Tretinoin
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	90 days
Participants	171

Intervention	Tretinoin
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	280 days
Participants	50

1 Study Found

Intervention	Bakuchiol
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	44

1 Study Found

Intervention	N-Acetyl Glucosamine + Niacinamide
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	202

1 Study Found

Intervention	Niacinamide + Sericin + Signaline
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	30

3 Studies Found

Intervention	Thiamidol
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Participants	37

Intervention	Thiamidol
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	80

Intervention	Thiamidol
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	123

1 Study Found

Intervention	Niacinamide + Sepiwhite
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	232

1 Study Found

Intervention	Arbutin + Galactomyces Ferment Filtrate + Niacinamide + Tranexamic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Randomised Controlled
Trial Duration	28 days
Participants	44

1 Study Found

Intervention	Hyaluronic Acid + Panthenol + Thiamidol
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	90 days
Participants	50

1 Study Found

Intervention	Hyaluronic Acid + Thiamidol
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	30

2 Studies Found

Intervention	Adapalene
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	90 days
Participants	171

Intervention	Adapalene
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	252 days
Participants	90

1 Study Found

Intervention	Gluconolactone
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	57

1 Study Found

Intervention	Glycolic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	57

1 Study Found

Intervention	Delta-Tocopherol Glucoside + Glycylglycine Oleamide + Retinal
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	57

2 Studies Found

Intervention	Kinetin
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	18

Intervention	Kinetin
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	100

1 Study Found

Intervention	Hyaluronic Acid + Retinal
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	90 days
Participants	1462

1 Study Found

Intervention	Gluconolactone + Glycolic Acid + Lactobionic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	30

1 Study Found

Intervention	Ascorbic Acid + Tetrahexyldecyl Ascorbate
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	10

1 Study Found

Intervention	Kinetin + Niacinamide
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	52

1 Study Found

Intervention	Linoleic Acid + Niacinamide + Oxidised Glutathione + Oxyresveratrol + Tranexamic Acid
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	26

1 Study Found

Intervention	Ammonium Lactate
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	56 days
Participants	21

1 Study Found

Intervention	Arbutin + Bisabolol + Niacinamide + Retinal
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	60 days
Participants	35

1 Study Found

Intervention	Pterostilbene
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Esoterica
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	155

1 Study Found

Intervention	Aestura Regederm RX White Project
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	42

1 Study Found

Intervention	Purpose Daily Use UV Moisturiser + Tretinoin
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

1 Study Found

Intervention	Renova
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

1 Study Found

Intervention	RoC Retinol Correxion Deep Wrinkle Night Cream
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	64

3 Studies Found

Intervention	Retin-A
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	40

Intervention	Retin-A
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	90 days
Participants	171

Intervention	Retin-A
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	280 days
Participants	50

5 Studies Found

Intervention	Imedeen
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	100

Intervention	Imedeen
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Randomised Uncontrolled
Trial Duration	336 days
Participants	144

Intervention	Imedeen
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Participants	30

Intervention	Imedeen
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	90 days
Participants	40

Intervention	Imedeen
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	90 days
Participants	6

3 Studies Found

Intervention	Imedeen Time Perfection
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	91

Intervention	Imedeen Time Perfection
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	120 days
Participants	50

Intervention	Imedeen Time Perfection
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	194

1 Study Found

Intervention	Vivida
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Participants	30

1 Study Found

Intervention	Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

1 Study Found

Intervention	Dermage Clarite Cysteamin
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	120 days
Participants	40

1 Study Found

Intervention	Eucerin UltraWHITE Spotless Double Booster Serum
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	30

1 Study Found

Intervention	Eucerin Anti-Pigment Day SPF30
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	117

1 Study Found

Intervention	Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	117

1 Study Found

Intervention	Avene A-OXitive NIGHT Peeling Cream
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	57

1 Study Found

Intervention	Finacea
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	112 days
Participants	20

1 Study Found

Intervention	Isdinceutics Melaclear
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	10

1 Study Found

Intervention	SkinAx²
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	56 days
Participants	35

2 Studies Found

Intervention	Kinerase
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	18

Intervention	Kinerase
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	100

1 Study Found

Intervention	Neora Age IQ Night Cream
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	SkinCeuticals Discoloration Defense
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	55

1 Study Found

Intervention	Avene Eluage Cream + Avene Eluage Anti-Wrinkle Concentrate
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	90 days
Participants	1462

1 Study Found

Intervention	La Roche-Posay Active C
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	20

2 Studies Found

Intervention	Isdinceutics Melatonik
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	168 days
Participants	24

Intervention	Isdinceutics Melatonik
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	103

1 Study Found

Intervention	ISDIN FotoUltra 100 Spot Prevent Fusion Fluid + Isdinceutics Pigment Expert
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	12

2 Studies Found

Intervention	Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30 + Eucerin Anti-Pigment Night
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	117

Intervention	Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30 + Eucerin Anti-Pigment Night
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	123

1 Study Found

Intervention	Revision Skincare Retinol Complete + Revision Skincare Vitamin C Lotion 30%
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	44

1 Study Found

Intervention	Imedeen Derma One
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	201

1 Study Found

Intervention	Imedeen Man-Age-Ment
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	210 days
Participants	47

1 Study Found

Intervention	Avene Eluage Anti-Wrinkle Concentrate
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	90 days
Participants	1462

1 Study Found

Intervention	Cellex-C High-Potency Serum
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	28

1 Study Found

Intervention	Avene Eluage Cream
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	90 days
Participants	1462

1 Study Found

Intervention	Burt's Bees Renewal Refining Cleanser + Burt's Bees Renewal Moisturizing Cream
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	28 days
Participants	60

1 Study Found

Intervention	PteroWhite
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Lac-Hydrin
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	56 days
Participants	21

1 Study Found

Intervention	Boots No7 Protect & Perfect Intense Beauty Serum
Concern	Hyperpigmentation
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	365 days
Participants	70

Latest Research

Hyperpigmentation

Coming soon.

8 Studies Found

Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma

Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma

A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma

The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream

Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma

A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women

Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial

2 Studies Found

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo

A double-blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma

3 Studies Found

A comparative study of topical 5% cysteamine versus 4% hydroquinone in the treatment of facial melasma in women

Efficacy of cysteamine cream in the treatment of epidermal melasma, evaluating by Dermacatch as a new measurement method: a randomized double blind placebo controlled study

Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double-blind placebo-controlled trial

5 Studies Found

Double-blind comparison of azelaic acid and hydroquinone in the treatment of melasma

The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream

Comparative study of therapeutic effects of 20% azelaic acid and hydroquinone 4% cream in the treatment of melasma

Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study

Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients

1 Study Found

Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial

5 Studies Found

Reduction in the appearance of facial hyperpigmentation by topical N-undecyl-10-enoyl-L-phenylalanine and its combination with niacinamide

The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial

Effective inhibition of melanosome transfer to keratinocytes by lectins and niacinamide is reversible

Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin

3 Studies Found

One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial

Improvement of photoaged facial skin in middle-aged Japanese females by topical retinol (vitamin A alcohol): a vehicle-controlled, double-blind study

Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing

4 Studies Found

Topical tretinoin for treatment of photodamaged skin. A multicenter study

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study

Efficacy and safety of adapalene gel 0.1% and 0.3% and tretinoin gel 0.05% for acne vulgaris: results of a single-center, randomized, double-blinded, placebo-controlled clinical trial on Mexican patients (skin type III-IV)

Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial

1 Study Found

Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing

1 Study Found

Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial

1 Study Found

Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing

3 Studies Found

Inhibition of Human Tyrosinase Requires Molecular Motifs Distinctively Different from Mushroom Tyrosinase

Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma

Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol)

1 Study Found

Reduction in the appearance of facial hyperpigmentation by topical N-undecyl-10-enoyl-L-phenylalanine and its combination with niacinamide

1 Study Found

Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals

1 Study Found

Efficacy and safety of topical isobutylamido thiazolyl resorcinol (Thiamidol) vs. 4% hydroquinone cream for facial melasma: an evaluator-blinded, randomized controlled trial

1 Study Found

Isobutylamido thiazolyl resorcinol for prevention of UVB-induced hyperpigmentation

2 Studies Found

Efficacy and safety of adapalene gel 0.1% and 0.3% and tretinoin gel 0.05% for acne vulgaris: results of a single-center, randomized, double-blinded, placebo-controlled clinical trial on Mexican patients (skin type III-IV)

Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial

1 Study Found

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen

1 Study Found

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen

1 Study Found

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study

2 Studies Found

Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea

Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin

1 Study Found

Retinaldehyde/hyaluronic acid fragments: a synergistic association for the management of skin aging

1 Study Found

Anti-Aging Effects and Tolerability of High Strength Hydroxy Acids in Males with Moderate to Severe Photoaging

1 Study Found

Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage

1 Study Found

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial

1 Study Found