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Long-term topical oestrogen treatment of sun-exposed facial skin in post-menopausal women does not improve facial wrinkles or skin elasticity, but induces matrix metalloproteinase-1 expression
Study Design
Subject Type
Human
Trial Design
Double-Blind, Randomised, Controlled
Trial Duration
168 days
Participants
80 (76 completed)
Age Range
51-60 years
Efficacy
Intervention(s)
Outcome
Method
Effect
Description
Estrone
Fine Lines
Visiometer
🠩
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Estrone
Skin Elasticity
Cutometer
–
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Estrone
Wrinkles
Visiometer
–
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Mechanisms
Intervention(s)
Outcome
Method
Effect
Description
Estrone
Collagen
Immunohistochemistry
⇧⇩
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Estrone
Collagenase
Quantitative RT-PCR
🠩
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Estrone
Fibrillin
Immunohistochemistry
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Study Summary
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