Fine Lines

Ingredients

Show 5 more ingredients
Ingredient	Grade	Effect	Evidence	Studies
Tretinoin	C	Slight Decrease	Fair	2 studies 197 participants
Delta-Tocopherol Glucoside + Glycylglycine Oleamide + Retinal	C	Slight Decrease	Fair	2 studies 91 participants
Retinol	C	Slight Decrease	Fair	2 studies 126 participants
Adapalene	D	Slight Decrease	Some	1 study 42 participants
Gluconolactone	D	Slight Decrease	Some	1 study 57 participants
Glycolic Acid	D	Slight Decrease	Some	1 study 57 participants
SIG-1273	D	Potential Decrease	Some	1 study 29 participants
Pterostilbene	D	Potential Decrease	Some	1 study 38 participants
Gluconolactone + Glycolic Acid + Lactobionic Acid	D	Potential Decrease	Some	1 study 29 participants
Ascorbic Acid	E	Mixed Effect	Some	2 studies 42 participants

Products

Show 9 more products
Product	Grade	Effect	Evidence	Studies
Avene A-OXitive NIGHT Peeling Cream	C	Slight Decrease	Fair	2 studies 91 participants
La Roche-Posay Active C	C	Slight Increase	Fair	1 study 19 participants
Renova	C	Slight Decrease	Fair	1 study 167 participants
Retin-A	C	Slight Decrease	Fair	1 study 30 participants
Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin	C	Slight Decrease	Fair	1 study 37 participants
Purpose Daily Use UV Moisturiser + Tretinoin	C	Slight Decrease	Fair	1 study 37 participants
RoC Retinol Correxion Deep Wrinkle Night Cream	C	Slight Decrease	Fair	1 study 36 participants
Cellex-C High-Potency Serum	C	Slight Decrease	Fair	1 study 19 participants
Imedeen	D	Slight Decrease	Some	1 study 111 participants
Imedeen Time Perfection	D	Potential Decrease	Fair	3 studies 287 participants
PteroWhite	D	Potential Decrease	Some	1 study 38 participants
Revision Skincare Retinol Complete + Revision Skincare Vitamin C Lotion 30%	D	Potential Decrease	Some	1 study 44 participants
Isdinceutics Melatonik	D	Potential Decrease	Some	1 study 24 participants
Imedeen Man-Age-Ment	E	No Effect	Some	1 study 41 participants

Treatments

Coming soon.

Skincare treatments can penetrate more deeply into the skin to provide faster, more dramatic and longer-lasting results than topical products, but they are also much more expensive.

Review all of the scientific evidence before spending thousands of dollars on treatments that won't work, or that make your skin worse due to the side effects.

Log in to register your interest in knowing when information on skincare treatments becomes available on Wisderm.com, and get a 20% discount on launch!

2 Studies Found

Intervention	Tretinoin
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

Intervention	Tretinoin
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	40

2 Studies Found

Intervention	Delta-Tocopherol Glucoside + Glycylglycine Oleamide + Retinal
Concern	Fine Lines
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	56 days
Participants	36

Intervention	Delta-Tocopherol Glucoside + Glycylglycine Oleamide + Retinal
Concern	Fine Lines
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	57

2 Studies Found

Intervention	Retinol
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	64

Intervention	Retinol
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	182 days
Participants	106

1 Study Found

Intervention	Adapalene
Concern	Fine Lines
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	252 days
Participants	90

1 Study Found

Intervention	Gluconolactone
Concern	Fine Lines
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	57

1 Study Found

Intervention	Glycolic Acid
Concern	Fine Lines
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	57

1 Study Found

Intervention	SIG-1273
Concern	Fine Lines
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	28 days
Participants	31

1 Study Found

Intervention	Pterostilbene
Concern	Fine Lines
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Gluconolactone + Glycolic Acid + Lactobionic Acid
Concern	Fine Lines
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	30

2 Studies Found

Intervention	Ascorbic Acid
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	20

Intervention	Ascorbic Acid
Concern	Fine Lines
Subject Type	Human
Trial Design	Randomised Controlled
Trial Duration	84 days
Participants	75

2 Studies Found

Intervention	Avene A-OXitive NIGHT Peeling Cream
Concern	Fine Lines
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	56 days
Participants	36

Intervention	Avene A-OXitive NIGHT Peeling Cream
Concern	Fine Lines
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	57

1 Study Found

Intervention	La Roche-Posay Active C
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	20

1 Study Found

Intervention	Renova
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

1 Study Found

Intervention	Retin-A
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	40

1 Study Found

Intervention	Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

1 Study Found

Intervention	Purpose Daily Use UV Moisturiser + Tretinoin
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

1 Study Found

Intervention	RoC Retinol Correxion Deep Wrinkle Night Cream
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	64

1 Study Found

Intervention	Cellex-C High-Potency Serum
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	28

1 Study Found

Intervention	Imedeen
Concern	Fine Lines
Subject Type	Human
Trial Design	Open-Label Randomised Uncontrolled
Trial Duration	336 days
Participants	144

3 Studies Found

Intervention	Imedeen Time Perfection
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	91

Intervention	Imedeen Time Perfection
Concern	Fine Lines
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	120 days
Participants	50

Intervention	Imedeen Time Perfection
Concern	Fine Lines
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	194

1 Study Found

Intervention	PteroWhite
Concern	Fine Lines
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Revision Skincare Retinol Complete + Revision Skincare Vitamin C Lotion 30%
Concern	Fine Lines
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	44

1 Study Found

Intervention	Isdinceutics Melatonik
Concern	Fine Lines
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	168 days
Participants	24

1 Study Found

Intervention	Imedeen Man-Age-Ment
Concern	Fine Lines
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	210 days
Participants	47

Latest Research

Coming soon.

2 Studies Found

Topical tretinoin for treatment of photodamaged skin. A multicenter study

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study

2 Studies Found

A new dermocosmetic containing retinaldehyde, delta-tocopherol glucoside and glycylglycine oleamide for managing naturally aged skin: results from in vitro to clinical studies

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study

2 Studies Found

One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial

Improvement of photoaged facial skin in middle-aged Japanese females by topical retinol (vitamin A alcohol): a vehicle-controlled, double-blind study

1 Study Found

Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial

1 Study Found

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen

1 Study Found

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen

1 Study Found

In vitro and clinical evaluation of SIG1273: a cosmetic functional ingredient with a broad spectrum of anti-aging and antioxidant activities

1 Study Found

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects

1 Study Found

Anti-Aging Effects and Tolerability of High Strength Hydroxy Acids in Males with Moderate to Severe Photoaging

2 Studies Found

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo

Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy

2 Studies Found

A new dermocosmetic containing retinaldehyde, delta-tocopherol glucoside and glycylglycine oleamide for managing naturally aged skin: results from in vitro to clinical studies

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study

1 Study Found

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo

1 Study Found

Topical tretinoin for treatment of photodamaged skin. A multicenter study

1 Study Found

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study

1 Study Found

Facilitating facial retinization through barrier improvement

1 Study Found

Facilitating facial retinization through barrier improvement

1 Study Found

One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial

1 Study Found

Use of topical ascorbic acid and its effects on photodamaged skin topography

1 Study Found

Imedeen in the treatment of photoaged skin: an efficacy and safety trial over 12 months

3 Studies Found

A placebo-controlled, double-blind clinical trial to evaluate the efficacy of Imedeen Time Perfection for improving the appearance of photodamaged skin

Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women

1 Study Found

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects

1 Study Found

An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol and Vitamin C Facial Regimen in Women With Mild-to-Moderate Hyperpigmentation and Photodamaged Facial Skin

1 Study Found

Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis

1 Study Found

Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men

Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis (2020)

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects (2020)

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study (2018)

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study (2018)

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women (2017)