Fine Lines

The Clinical Efficacy and Tolerability of a Novel Retinaldehyde Serum with Firming Peptides to Improve Skin Texture and Signs of Photoaging (2024)

A Novel Protection and Repair Skincare Regimen Shows Efficacy for Improving Environmental Skin Aging (2024)

Open-label topical application of tetrahexyldecyl ascorbate and acetyl zingerone containing serum improves the appearance of photoaging and uneven pigmentation (2024)

Multicenter evaluation of a topical antioxidant serum (2024)

A Multi-Center, Randomized, Blinded Clinical Study Evaluating the Efficacy and Safety of a Novel Topical Product for Facial Dyschromia (2023)

Benefits of the Dermocosmetic Mineral 89 Probiotic Fractions Adjunct to Topical Retinoids for Anti-Aging Benefits (2023)

Topical formulation containing peptides and vitamin C in ampoules improves skin aging signs: Results of a large, international, observational study (2022)

Multicenter evaluation of a topical hyaluronic acid serum (2022)

Effect of green tea extract loaded chitosan microparticles on facial skin: A split-face, double-blind, randomized placebo-controlled study (2022)

A dermocosmetic formulation containing Vichy volcanic mineralizing water, Vitreoscilla filiformis extract, niacinamide, hyaluronic acid, and vitamin E regenerates and repairs acutely stressed skin (2022)

Effectiveness of a formulation containing peptides and vitamin C in treating signs of facial ageing: three clinical studies (2021)

Efficacy and Tolerability of a Novel Topical Treatment for Neck: A Randomized, Double-blind, Regimen-Controlled Study (2021)

A novel skin brightening topical technology (2020)

Clinical Benefits of Circadian-based Antioxidant Protection and Repair (2020)

Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis (2020)

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects (2020)

Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial (2019)

Global periorbital skin rejuvenation by a topical eye cream containing low molecular weight heparan sulfate (LMW-HS) and a blend of naturally derived extracts (2019)

A single-center clinical trial to evaluate the efficacy of a tripeptide/hexapeptide antiaging regimen (2019)

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study (2018)

A single-center, pilot study evaluating a novel TriHex peptide- and botanical-containing eye treatment compared to baseline (2018)

Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation (2017)

The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study (2017)

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women (2017)

A new dermocosmetic containing retinaldehyde, delta-tocopherol glucoside and glycylglycine oleamide for managing naturally aged skin: results from in vitro to clinical studies (2017)

Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol (2016)

A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females (2016)

In vitro and clinical evaluation of SIG1273: a cosmetic functional ingredient with a broad spectrum of anti-aging and antioxidant activities (2016)

An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol and Vitamin C Facial Regimen in Women With Mild-to-Moderate Hyperpigmentation and Photodamaged Facial Skin (2016)

A placebo-controlled, double-blind clinical trial to evaluate the efficacy of Imedeen Time Perfection for improving the appearance of photodamaged skin (2016)

Superior Efficacy of an Herbal-based Cosmeceutical Compared With Common Prescription and Cosmetic Antiaging Therapies (2016)

Improvement in Atrophic Acne Scars Using Topical Synthetic Epidermal Growth Factor (EGF) Serum: A Pilot Study (2015)

Facial primer provides immediate and long-term improvements in mild-to-moderate facial hyperpigmentation and fine lines associated with photoaging (2015)

Long-term Multi-product Facial Regimen in Subjects with Moderate-to-severe Photodamage and Hyperpigmentation (2015)

An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin (2015)

The Potential Role of Topically Applied Heparan Sulfate in the Treatment of Photodamage (2015)

4-Hexyl-1,3-phenylenediol, a nuclear factor-κB inhibitor, improves photodamaged skin and clinical signs of ageing in a double-blinded, randomized controlled trial (2015)

Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men (2015)

Assessment of the safety and efficacy of topical copper chlorophyllin in women with photodamaged facial skin (2015)

One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial (2015)

A randomized, double-blind, split-face study comparing the efficacy and tolerability of three retinol-based products vs. three tretinoin-based products in subjects with moderate to severe facial photodamage (2015)

A single center, pilot, double-blinded, randomized, comparative, prospective clinical study to evaluate improvements in the structure and function of facial skin with tazarotene 0.1% cream alone and in combination with GliSODin(®) Skin Nutrients Advanced Anti-Aging Formula (2014)

The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle (2014)

Long-term topical oestrogen treatment of sun-exposed facial skin in post-menopausal women does not improve facial wrinkles or skin elasticity, but induces matrix metalloproteinase-1 expression (2014)

Efficacy of a novel treatment serum in the improvement of photodamaged skin (2013)

The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites (2013)

Improved texture and appearance of human facial skin after daily topical application of barley produced, synthetic, human-like epidermal growth factor (EGF) serum (2012)

Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin (2012)

Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin: a double-blind, randomized-controlled trial (2011)

An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging (2010)

Combination of physiologically balanced growth factors with antioxidants for reversal of facial photodamage (2010)

Clinical Safety and Efficacy in Photoaged Skin With CoffeeBerry Extract, a Natural Antioxidant (2009)

Evaluation of anti-wrinkle effects of a novel cosmetic containing retinol using the guideline of the Japan Cosmetic Industry Association (2009)

A two-year, double-blind, randomized placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histologic appearance of photoaging skin (2009)

Improvement of photoaged facial skin in middle-aged Japanese females by topical retinol (vitamin A alcohol): a vehicle-controlled, double-blind study (2009)

Anti-Aging Effects and Tolerability of High Strength Hydroxy Acids in Males with Moderate to Severe Photoaging (2009)

Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin (2008)

A novel treatment option for photoaged skin (2008)

Antiaging Effects of Topical Lactobionic Acid: Results of A Controlled Usage Study (2008)

Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage (2007)

Efficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study (2007)

Facilitating facial retinization through barrier improvement (2006)

Tazarotene versus tazarotene plus hydroquinone in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized study (2006)

Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone (2005)

Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging (2005)

A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage (2005)

Long-term efficacy and safety of tretinoin emollient cream 0.05% in the treatment of photodamaged facial skin: a two-year, randomized, placebo-controlled trial (2005)

Histological effects of tazarotene 0.1% cream vs. vehicle on photodamaged skin: a 6-month, multicentre, double-blind, randomized, vehicle-controlled study in patients with photodamaged facial skin (2004)

Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy (2004)

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen (2004)

The use of polyhydroxy acids (PHAs) in photoaged skin (2004)

Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin (2003)

Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial (2003)

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo (2003)

Efficacy of 0.1% tazarotene cream for the treatment of photodamage: a 12-month multicenter, randomized trial (2002)

Clinical study of safety and efficacy of using topical kinetin 0.1% (Kinerase®) to treat photodamaged skin (2002)

Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks (2001)

Topical 5% alpha lipoic acid cream in the treatment of cutaneous rhytids (2000)

Use of topical ascorbic acid and its effects on photodamaged skin topography (1999)

Imedeen in the treatment of photoaged skin: an efficacy and safety trial over 12 months (1998)

A clinicopathological study of the effects of topical retinyl propionate cream in skin photoageing (1998)

Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind vehicle-controlled clinical trial (1996)

Mechanism of action of a lipophilic derivative of salicylic acid on normal skin (1995)

Tretinoin emollient cream 0.01% for the treatment of photoaged skin (1993)

Tretinoin emollient cream: a new therapy for photodamaged skin (1992)

Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream (1991)

Topical tretinoin for treatment of photodamaged skin. A multicenter study (1991)

Sustained improvement with prolonged topical tretinoin (retinoic acid) for photoaged skin (1990)

Treatment of photodamaged facial skin with topical tretinoin (1989)

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study (1988)