A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen

Efficacy

Intervention(s)		Outcome		Effect	Description
Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment		Skin Barrier Function		Increase	Login to read descriptions for free
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Tretinoin Renova		Skin Barrier Function		Decrease	Login to read descriptions for free
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Tretinoin Renova		Skin Smoothness		Increase	Login to read descriptions for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment		Skin Smoothness		Increase	Login to read descriptions for free
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Tretinoin Renova		Wrinkles		Decrease	Login to read descriptions for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment		Wrinkles		Decrease	Login to read descriptions for free
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Mechanisms

Intervention(s)		Outcome		Effect	Description
Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment		Human Serum Albumin		Decrease	Login to read descriptions for free
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Tretinoin Renova		Human Serum Albumin		Increase	Login to read descriptions for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment		Involucrin		Decrease	Login to read descriptions for free
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Tretinoin Renova		Involucrin		Increase	Login to read descriptions for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment		Keratin		Increase	Login to read descriptions for free
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Tretinoin Renova		Keratin		Decrease	Login to read descriptions for free
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Tretinoin Renova		Soluble Protein		Increase	Login to read descriptions for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment		Soluble Protein		Decrease	Login to read descriptions for free
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Side Effects

Intervention(s)		Outcome	Effect	Description
Tretinoin Renova		Skin Hydration	Decrease	Login to read descriptions for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment		Skin Hydration	No Effect	Login to read descriptions for free
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Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment		Skin Redness	Increase	Login to read descriptions for free
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Tretinoin Renova		Skin Redness	Increase	Login to read descriptions for free
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Study Design

Subject Type

Human

Trial Design

Single-Blind, Randomised, Controlled

Trial Duration

168 days

Participants

196 (190 completed)

Age Range

40-65 years

Study Summary

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