Skin Smoothness

A Multi-Center, Double-Blind, Randomized, Comparator Controlled Trial Evaluating Topical Formulations for Skin Fragility of the Arms (2024)

The Clinical Efficacy and Tolerability of a Novel Retinaldehyde Serum with Firming Peptides to Improve Skin Texture and Signs of Photoaging (2024)

A Novel Protection and Repair Skincare Regimen Shows Efficacy for Improving Environmental Skin Aging (2024)

Open-label topical application of tetrahexyldecyl ascorbate and acetyl zingerone containing serum improves the appearance of photoaging and uneven pigmentation (2024)

Oral consumption of Bonito fish-derived elastin peptide (VGPG Elastin® ) improves biophysical properties in aging skin: A randomized, double-blinded, placebo-controlled study (2024)

Multicenter evaluation of a topical antioxidant serum (2024)

Clinical and histologic findings after use of a novel combined retinol, tripeptide, and glaucine containing cream in the treatment of photo-aged skin (2023)

Restoration of Aging Body Skin: Evidence-Based Development of a Topical Formulation for Improving Body Skin Quality (2023)

A Multi-Center, Randomized, Blinded Clinical Study Evaluating the Efficacy and Safety of a Novel Topical Product for Facial Dyschromia (2023)

Evaluation of a New, Advanced Antioxidant Containing Topical Allyl Pyrroloquinoline Quinone: Analysis of Antioxidant Properties and Visible Effects in Subjects with Facial Photodamage (2023)

Impact of defensins-containing body cream on skin composition (2023)

Low-molecular-weight collagen peptides supplement promotes a healthy skin: A randomized, double-blinded, placebo-controlled study (2023)

Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months-An 11-Year Longitudinal Skin Aging Rejuvenation Study (2023)

Protective effects of a day/night dual-antioxidant serum on skin: A randomized, regimen-controlled study in Chinese women exposed to air pollution (2023)

Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study (2022)

Efficacy Evaluation of a Cosmetic Product for the Periocular Area in Caucasian Women Aged Over 40 Years Old (2022)

Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs (2022)

An Open-Label Clinical Trial Analyzing the Efficacy of a Novel Telomere-Protecting Antiaging Face Cream (2022)

Multicenter evaluation of a topical hyaluronic acid serum (2022)

Efficacy and tolerability of a hyaluronic acid-based serum and a peptide-rich cream for the face and neck in subjects with photodamaged skin (2022)

An Open-Label Study Assessing the Efficacy and Tolerability of a Skincare Regimen in Subjects of Different Ethnicities with Moderate-to-Severe Hyperpigmentation (2022)

A Prospective, Randomized, Double-Blind, Vehicle-Controlled Study Evaluating the Efficacy, Safety, and Patient Satisfaction of Tretinoin 0.05% Lotion for Chest Rejuvenation (2022)

An open-label, investigator-initiated, single-center, prospective, pilot clinical study to evaluate the efficacy of a skin whitening serum applied twice daily combined with a spot-preventing SPF50+ sunscreen in healthy female subjects with melasma hyperpigmentation (2022)

Effect of a Topical Collagen Tripeptide on Antiaging and Inhibition of Glycation of the Skin: A Pilot Study (2022)

A dermocosmetic formulation containing Vichy volcanic mineralizing water, Vitreoscilla filiformis extract, niacinamide, hyaluronic acid, and vitamin E regenerates and repairs acutely stressed skin (2022)

A pilot study evaluating the efficacy and tolerability of a comprehensive, hydrating topical antioxidant developed specifically for men (2021)

Prospective, Randomized, Comparative Study of the Cutaneous Effects of a Topical Body Treatment Compared to a Bland Moisturizer (2021)

Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study (2021)

Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula (2021)

Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study (2021)

A Randomized, Double-Blind, Split-Body, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Tolerability of a Topical Body Firming Moisturizer for Upper Arm Rejuvenation (2021)

Effectiveness of a formulation containing peptides and vitamin C in treating signs of facial ageing: three clinical studies (2021)

Efficacy and Tolerability of a Novel Topical Treatment for Neck: A Randomized, Double-blind, Regimen-Controlled Study (2021)

Clinical Benefits of Circadian-based Antioxidant Protection and Repair (2020)

Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin (2020)

Night Cream Containing Melatonin, Carnosine and Helichrysum italicum Extract Helps Reduce Skin Reactivity and Signs of Photodamage: Ex Vivo and Clinical Studies (2020)

Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study (2020)

Amazake made from sake cake and rice koji suppresses sebum content in differentiated hamster sebocytes and improves skin properties in humans (2020)

Effect of defensins-containing eye cream on periocular rhytids and skin quality (2020)

Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis (2020)

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects (2020)

SIG-1273 protects skin against urban air pollution and when formulated in AgeIQ™ Night Cream anti-aging benefits clinically demonstrated (2019)

Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial (2019)

Long-term objective assessments of skin rejuvenation using solar protection and solar repair shown through digital facial surface analysis and three-dimensional volumetric assessment (2019)

Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation (2019)

Brightening and Improvement of Facial Skin Quality in Healthy Female Subjects With Moderate Hyperpigmentation or Dark Spots and Moderate Facial Aging (2018)

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study (2018)

Topical Growth Factors for the Treatment of Facial Photoaging: A Clinical Experience of Eight Cases (2018)

Comparative efficacy of two anti-aging products containing retinyl palmitate in healthy human volunteers (2018)

Understanding Solar Skin Elastosis-Cause and Treatment (2018)

Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation (2018)

Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation (2017)

Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study (2017)

Topical equol preparation improves structural and molecular skin parameters (2017)

Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical Study (2017)

A Prospective, Randomized, Double-blind, Split-face Clinical Trial Comparing the Efficacy of Two Topical Human Growth Factors for the Rejuvenation of the Aging Face (2017)

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women (2017)

The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study (2017)

Clinical effects of an oral supplement rich in antioxidants on skin radiance in women (2016)

Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study (2016)

Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo (2016)

Efficacy and Tolerability of a Skin Brightening/Anti-Aging Cosmeceutical Containing Retinol 0.5%, Niacinamide, Hexylresorcinol, and Resveratrol (2016)

A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females (2016)

In vitro and clinical evaluation of SIG1273: a cosmetic functional ingredient with a broad spectrum of anti-aging and antioxidant activities (2016)

Assessment of a Novel Anti-Aging Hand Cream (2016)

A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating an Oral Anti-aging Skin Care Supplement for Treating Photodamaged Skin (2016)

An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol and Vitamin C Facial Regimen in Women With Mild-to-Moderate Hyperpigmentation and Photodamaged Facial Skin (2016)

Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs (2016)

A placebo-controlled, double-blind clinical trial to evaluate the efficacy of Imedeen Time Perfection for improving the appearance of photodamaged skin (2016)

Clinical Assessment of a Novel Jasmonate Cosmeceutical, LR2412-Cx, for the Treatment of Skin Aging (2016)

Superior Efficacy of an Herbal-based Cosmeceutical Compared With Common Prescription and Cosmetic Antiaging Therapies (2016)

Rejuvenating Hydrator: Restoring Epidermal Hyaluronic Acid Homeostasis With Instant Benefits (2016)

Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing (2015)

Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology (2015)

A novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% for treatment of epidermal melasma (2015)

Facial primer provides immediate and long-term improvements in mild-to-moderate facial hyperpigmentation and fine lines associated with photoaging (2015)

Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin (2015)

Long-term Multi-product Facial Regimen in Subjects with Moderate-to-severe Photodamage and Hyperpigmentation (2015)

Total Defense + Repair: A Novel Concept in Solar Protection and Skin Rejuvenation (2015)

An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin (2015)

Pilot Study of Topical Copper Chlorophyllin Complex in Subjects With Facial Acne and Large Pores (2015)

Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men (2015)

Assessment of the safety and efficacy of topical copper chlorophyllin in women with photodamaged facial skin (2015)

A double-blind randomized study comparing the association of Retinol and LR2412 with tretinoin 0.025% in photoaged skin (2015)

A randomized, double-blind, split-face study comparing the efficacy and tolerability of three retinol-based products vs. three tretinoin-based products in subjects with moderate to severe facial photodamage (2015)

Clinical effects of ingesting collagen hydrolysate on facial skin properties: A randomized, placebo-controlled, double-blind trial (2015)

Evaluation of a novel anti-aging topical formulation containing cycloastragenol, growth factors, peptides, and antioxidants (2014)

Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration (2014)

Novel cosmetic patches for wrinkle improvement: retinyl retinoate- and ascorbic acid-loaded dissolving microneedles (2014)

Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study (2013)

Tannase-converted green tea catechins and their anti-wrinkle activity in humans (2013)

The use of green tea extract in cosmetic formulations: not only an antioxidant active ingredient (2013)

Combined topical application of lotus and green tea improves facial skin surface parameters (2013)

Efficacy of a novel treatment serum in the improvement of photodamaged skin (2013)

The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites (2013)

Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: stability studies and in vivo efficacy (2012)

Improved texture and appearance of human facial skin after daily topical application of barley produced, synthetic, human-like epidermal growth factor (EGF) serum (2012)

Novel anti-wrinkle effect of cosmeceutical product with new retinyl retinoate microsphere using biodegradable polymer (2012)

Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women (2012)

Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin (2012)

Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment (2011)

Retinyl retinoate, a novel hybrid vitamin derivative, improves photoaged skin: a double-blind, randomized-controlled trial (2011)

Supplementation of flaxseed oil diminishes skin sensitivity and improves skin barrier function and condition (2011)

Three clinical studies showing the anti-aging benefits of sodium salicylate in human skin (2010)

An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging (2010)

Evaluation of a kojic acid, emblica extract, and glycolic acid formulation compared with hydroquinone 4% for skin lightening (2010)

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen (2010)

Combination of physiologically balanced growth factors with antioxidants for reversal of facial photodamage (2010)

Clinical Safety and Efficacy in Photoaged Skin With CoffeeBerry Extract, a Natural Antioxidant (2009)

An oral nutraceutical containing antioxidants, minerals and glycosaminoglycans improves skin roughness and fine wrinkles (2009)

Effects of a cosmetic 'anti-ageing' product on photoaged skin (2009)

A two-year, double-blind, randomized placebo-controlled trial of oral green tea polyphenols on the long-term clinical and histologic appearance of photoaging skin (2009)

Anti-Aging Effects and Tolerability of High Strength Hydroxy Acids in Males with Moderate to Severe Photoaging (2009)

Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin (2008)

Clinical, histologic, and ultrastructural changes after use of human growth factor and cytokine skin cream for the treatment of skin rejuvenation (2008)

A novel treatment option for photoaged skin (2008)

Antiaging Effects of Topical Lactobionic Acid: Results of A Controlled Usage Study (2008)

A double-blind, randomized clinical trial evaluating the dermatologic benefits of coffee berry extract (2008)

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial (2007)

Topical manganese peptide in the treatment of photodamaged skin (2007)

Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage (2007)

Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea (2007)

Efficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study (2007)

In vivo assessment of Ectoin: a randomized, vehicle-controlled clinical trial (2007)

Improvement of naturally aged skin with vitamin A (retinol) (2007)

Formulation, characterization, and efficacy of an adenosine-containing dissolvable film for a localized anti-wrinkle effect (2007)

Efficacy and tolerability of kinetin 0.1% cream for improving the signs of photoaging in facial and neck skin (2006)

Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS technique (2006)

Facilitating facial retinization through barrier improvement (2006)

Effect of a novel dietary supplement on skin aging in post-menopausal women (2006)

Tazarotene versus tazarotene plus hydroquinone in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized study (2006)

An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients (2006)

Clinical efficacy assessment in photodamaged skin of 0.5% and 1.0% idebenone (2005)

Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging (2005)

Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin (2005)

A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage (2005)

Long-term efficacy and safety of tretinoin emollient cream 0.05% in the treatment of photodamaged facial skin: a two-year, randomized, placebo-controlled trial (2005)

Histological effects of tazarotene 0.1% cream vs. vehicle on photodamaged skin: a 6-month, multicentre, double-blind, randomized, vehicle-controlled study in patients with photodamaged facial skin (2004)

Supplementation with Evelle improves skin smoothness and elasticity in a double-blind, placebo-controlled study with 62 women (2004)

The use of polyhydroxy acids (PHAs) in photoaged skin (2004)

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen (2004)

Effect of a fucose-rich polysaccharide preparation on the age-dependent evolution of the skin surface micro-relief (2003)

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo (2003)

Reversal of photodamage with topical growth factors: a pilot study (2003)

Phase II, clinical evaluation of 2% polyphenone (green tea extract) in a hydrophilic gel to assess improvement in damaged and premature aged facial skin. a placebo-controlled, double-blind study (2003)

Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation (2002)

Efficacy of 0.1% tazarotene cream for the treatment of photodamage: a 12-month multicenter, randomized trial (2002)

Clinical study of safety and efficacy of using topical kinetin 0.1% (Kinerase®) to treat photodamaged skin (2002)

Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks (2001)

Photodamage pilot study: a double-blind, vehicle-controlled study to assess the efficacy and safety of tazarotene 0.1% gel (2000)

Use of topical ascorbic acid and its effects on photodamaged skin topography (1999)

Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients (1998)

A double-blind randomized clinical trial on the effectiveness of a daily glycolic acid 5% formulation in the treatment of photoaging (1998)

Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind vehicle-controlled clinical trial (1996)

Mechanism of action of a lipophilic derivative of salicylic acid on normal skin (1995)

Tretinoin emollient cream 0.01% for the treatment of photoaged skin (1993)

Tretinoin emollient cream: a new therapy for photodamaged skin (1992)

Topical tretinoin for treatment of photodamaged skin. A multicenter study (1991)

Use of alpha-hydroxy acids in the therapy for 'photoaged' skin (1990)

Sustained improvement with prolonged topical tretinoin (retinoic acid) for photoaged skin (1990)

Treatment of photodamaged facial skin with topical tretinoin (1989)

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study (1988)

Hydration of the stratum corneum (1986)