Skin Smoothness

Ingredients

Show 13 more ingredients
Ingredient	Grade	Effect	Evidence	Studies
Niacinamide + Sericin + Signaline	C	Slight Increase	Fair	1 study 30 participants
Tretinoin	C	Slight Increase	Fair	3 studies 387 participants
Retinol	C	Slight Increase	Fair	1 study 36 participants
Glycolic Acid	D	Slight Increase	Some	1 study 57 participants
Gluconolactone	D	Slight Increase	Some	1 study 57 participants
Delta-Tocopherol Glucoside + Glycylglycine Oleamide + Retinal	D	Slight Increase	Some	1 study 57 participants
Azelaic Acid + Gluconolactone	D	Slight Increase	Some	1 study 62 participants
Kinetin + Niacinamide	D	Potential Increase	Fair	1 study 27 participants
SIG-1273	D	Potential Increase	Some	1 study 29 participants
Ascorbic Acid	D	Potential Increase	Fair	1 study 19 participants
Kinetin	D	Potential Increase	Fair	2 studies 117 participants
Pterostilbene	D	Potential Increase	Some	1 study 38 participants
Arbutin + Bisabolol + Niacinamide + Retinal	D	Potential Increase	Some	1 study 33 participants
Gluconolactone + Glycolic Acid + Lactobionic Acid	D	Potential Increase	Some	1 study 29 participants
Galactomyces Ferment Filtrate	D	Potential Increase	Some	1 study 104 participants
Azelaic Acid	E	Mixed Effect	Some	2 studies 97 participants
Niacinamide	E	No Effect	Fair	1 study 25 participants
Ammonium Lactate	E	No Effect	Some	1 study 21 participants

Products

Show 25 more products
Product	Grade	Effect	Evidence	Studies
Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin	C	Slight Increase	Fair	1 study 37 participants
Imedeen Time Perfection	C	Slight Increase	Fair	3 studies 287 participants
Cellex-C High-Potency Serum	C	Slight Increase	Fair	1 study 19 participants
Retin-A	C	Slight Increase	Fair	1 study 30 participants
Renova	C	Slight Increase	Fair	2 studies 357 participants
Imedeen Derma One	C	Slight Increase	Fair	1 study 152 participants
Purpose Daily Use UV Moisturiser + Tretinoin	C	Slight Increase	Fair	1 study 37 participants
Eucerin Anti-Pigment Day SPF30	D	Slight Increase	Some	1 study 34 participants
Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment	D	Slight Increase	Some	1 study 190 participants
Avene A-OXitive NIGHT Peeling Cream	D	Slight Increase	Some	1 study 57 participants
Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30	D	Slight Increase	Some	1 study 34 participants
Finacea + NeoStrata Facial Cleanser + NeoStrata Ultra Moisturizing Face Cream	D	Slight Increase	Some	1 study 62 participants
SkinCeuticals Discoloration Defense	D	Potential Increase	Some	1 study 55 participants
Burt's Bees Renewal Refining Cleanser + Burt's Bees Renewal Moisturizing Cream	D	Potential Increase	Some	1 study 60 participants
SkinAx²	D	Potential Increase	Some	1 study 35 participants
Pitera	D	Potential Increase	Some	1 study 104 participants
Neora Age IQ Night Cream	D	Potential Decrease	Some	1 study 37 participants
Imedeen Prime Renewal	D	Potential Increase	Fair	1 study 80 participants
Boots No7 Protect & Perfect Intense Beauty Serum	D	Potential Increase	Fair	1 study 60 participants
Revision Skincare Retinol Complete + Revision Skincare Vitamin C Lotion 30%	D	Potential Increase	Some	1 study 44 participants
Isdinceutics Melatonik	D	Potential Increase	Some	1 study 24 participants
Kinerase	D	Potential Increase	Fair	2 studies 117 participants
ISDIN FotoUltra 100 Spot Prevent Fusion Fluid + Isdinceutics Pigment Expert	D	Potential Increase	Some	1 study 11 participants
PteroWhite	D	Potential Increase	Some	1 study 38 participants
La Roche-Posay Active C	D	Potential Increase	Fair	1 study 19 participants
Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30 + Eucerin Anti-Pigment Night	D	Potential Increase	Some	1 study 83 participants
Imedeen Man-Age-Ment	D	Potential Increase	Some	1 study 41 participants
Isdinceutics Melaclear	D	Potential Increase	Some	1 study 10 participants
Finacea	E	No Effect	Some	1 study 62 participants
Lac-Hydrin	E	No Effect	Some	1 study 21 participants

Treatments

Coming soon.

Skincare treatments can penetrate more deeply into the skin to provide faster, more dramatic and longer-lasting results than topical products, but they are also much more expensive.

Review all of the scientific evidence before spending thousands of dollars on treatments that won't work, or that make your skin worse due to the side effects.

Log in to register your interest in knowing when information on skincare treatments becomes available on Wisderm.com, and get a 20% discount on launch!

1 Study Found

Intervention	Niacinamide + Sericin + Signaline
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	30

3 Studies Found

Intervention	Tretinoin
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

Intervention	Tretinoin
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	40

Intervention	Tretinoin
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	196

1 Study Found

Intervention	Retinol
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	36

1 Study Found

Intervention	Glycolic Acid
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	57

1 Study Found

Intervention	Gluconolactone
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	57

1 Study Found

Intervention	Delta-Tocopherol Glucoside + Glycylglycine Oleamide + Retinal
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	57

1 Study Found

Intervention	Azelaic Acid + Gluconolactone
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	67

1 Study Found

Intervention	Kinetin + Niacinamide
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	52

1 Study Found

Intervention	SIG-1273
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	28 days
Participants	31

1 Study Found

Intervention	Ascorbic Acid
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	20

2 Studies Found

Intervention	Kinetin
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	18

Intervention	Kinetin
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	100

1 Study Found

Intervention	Pterostilbene
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Arbutin + Bisabolol + Niacinamide + Retinal
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	60 days
Participants	35

1 Study Found

Intervention	Gluconolactone + Glycolic Acid + Lactobionic Acid
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	30

1 Study Found

Intervention	Galactomyces Ferment Filtrate
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	57 days
Participants	105

2 Studies Found

Intervention	Azelaic Acid
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	67

Intervention	Azelaic Acid
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	52

1 Study Found

Intervention	Niacinamide
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	52

1 Study Found

Intervention	Ammonium Lactate
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	56 days
Participants	21

1 Study Found

Intervention	Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

3 Studies Found

Intervention	Imedeen Time Perfection
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	91

Intervention	Imedeen Time Perfection
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	120 days
Participants	50

Intervention	Imedeen Time Perfection
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	194

1 Study Found

Intervention	Cellex-C High-Potency Serum
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	28

1 Study Found

Intervention	Retin-A
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	40

2 Studies Found

Intervention	Renova
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

Intervention	Renova
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	196

1 Study Found

Intervention	Imedeen Derma One
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	201

1 Study Found

Intervention	Purpose Daily Use UV Moisturiser + Tretinoin
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

1 Study Found

Intervention	Eucerin Anti-Pigment Day SPF30
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	117

1 Study Found

Intervention	Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	196

1 Study Found

Intervention	Avene A-OXitive NIGHT Peeling Cream
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	56 days
Participants	57

1 Study Found

Intervention	Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	117

1 Study Found

Intervention	Finacea + NeoStrata Facial Cleanser + NeoStrata Ultra Moisturizing Face Cream
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	67

1 Study Found

Intervention	SkinCeuticals Discoloration Defense
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	55

1 Study Found

Intervention	Burt's Bees Renewal Refining Cleanser + Burt's Bees Renewal Moisturizing Cream
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	28 days
Participants	60

1 Study Found

Intervention	SkinAx²
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	56 days
Participants	35

1 Study Found

Intervention	Pitera
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	57 days
Participants	105

1 Study Found

Intervention	Neora Age IQ Night Cream
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Imedeen Prime Renewal
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	100

1 Study Found

Intervention	Boots No7 Protect & Perfect Intense Beauty Serum
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	365 days
Participants	70

1 Study Found

Intervention	Revision Skincare Retinol Complete + Revision Skincare Vitamin C Lotion 30%
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	44

1 Study Found

Intervention	Isdinceutics Melatonik
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	168 days
Participants	24

2 Studies Found

Intervention	Kinerase
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	18

Intervention	Kinerase
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	100

1 Study Found

Intervention	ISDIN FotoUltra 100 Spot Prevent Fusion Fluid + Isdinceutics Pigment Expert
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	12

1 Study Found

Intervention	PteroWhite
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	La Roche-Posay Active C
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	20

1 Study Found

Intervention	Eucerin Anti-Pigment Dual Serum + Eucerin Anti-Pigment Day SPF30 + Eucerin Anti-Pigment Night
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	117

1 Study Found

Intervention	Imedeen Man-Age-Ment
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	210 days
Participants	47

1 Study Found

Intervention	Isdinceutics Melaclear
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	10

1 Study Found

Intervention	Finacea
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	67

1 Study Found

Intervention	Lac-Hydrin
Concern	Skin Smoothness
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	56 days
Participants	21

Latest Research

Skin Smoothness

Coming soon.

1 Study Found

Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing

3 Studies Found

Topical tretinoin for treatment of photodamaged skin. A multicenter study

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen

1 Study Found

Improvement of naturally aged skin with vitamin A (retinol)

1 Study Found

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen

1 Study Found

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen

1 Study Found

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study

1 Study Found

An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients

1 Study Found

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial

1 Study Found

In vitro and clinical evaluation of SIG1273: a cosmetic functional ingredient with a broad spectrum of anti-aging and antioxidant activities

1 Study Found

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo

2 Studies Found

Topical kinetin 0.1% lotion for improving the signs and symptoms of rosacea

Efficacy and safety of 0.1% kinetin cream in the treatment of photoaging skin

1 Study Found

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects

1 Study Found

A novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% for treatment of epidermal melasma

1 Study Found

Anti-Aging Effects and Tolerability of High Strength Hydroxy Acids in Males with Moderate to Severe Photoaging

1 Study Found

Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula

2 Studies Found

An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients

Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients

1 Study Found

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial

1 Study Found

Use of alpha-hydroxy acids in the therapy for 'photoaged' skin

1 Study Found

Facilitating facial retinization through barrier improvement

3 Studies Found

A placebo-controlled, double-blind clinical trial to evaluate the efficacy of Imedeen Time Perfection for improving the appearance of photodamaged skin

Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women

1 Study Found

Use of topical ascorbic acid and its effects on photodamaged skin topography

1 Study Found

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study

2 Studies Found

Topical tretinoin for treatment of photodamaged skin. A multicenter study

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen

1 Study Found

A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating an Oral Anti-aging Skin Care Supplement for Treating Photodamaged Skin

1 Study Found

Facilitating facial retinization through barrier improvement

1 Study Found

Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study

1 Study Found

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen

1 Study Found

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study

1 Study Found

Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study

1 Study Found

An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients

1 Study Found

Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation

1 Study Found

Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin

1 Study Found

Clinical effects of an oral supplement rich in antioxidants on skin radiance in women

1 Study Found

Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula

1 Study Found

SIG-1273 protects skin against urban air pollution and when formulated in AgeIQ™ Night Cream anti-aging benefits clinically demonstrated

1 Study Found