Skin Barrier Function

Ingredients

Show 12 more ingredients
Ingredient	Grade	Effect	Evidence	Studies
Niacinamide + Sericin + Signaline	C	Slight Increase	Fair	1 study 30 participants
Tretinoin	C	Slight Decrease	Fair	2 studies 188 participants
Gluconolactone	C	Slight Increase	Fair	2 studies 11 participants
Tartaric Acid	C	Slight Increase	Fair	1 study 11 participants
Glycolic Acid	C	Slight Increase	Fair	2 studies 11 participants
Niacinamide	D	Marked Increase	Some	2 studies 35 participants
Lactic Acid	D	Potential Increase	Fair	2 studies 11 participants
Retinal	D	Potential Decrease	Some	1 study
Galactomyces Ferment Filtrate	D	Potential Increase	Some	1 study 20 participants
Retinol	D	Potential Decrease	Some	1 study
Rice Ceramides	D	Potential Increase	Some	1 study 50 participants
Lactobionic Acid	E	Marked Increase	Basic	1 study
Petrolatum	E	No Effect	Some	1 study 15 participants
Glycylglycine	E	No Effect	Some	1 study 24 participants
Hyaluronic Acid	E	No Effect	Some	1 study 60 participants
Hyaluronic Acid + Thiamidol	E	No Effect	Some	1 study 60 participants
Thiamidol	E	No Effect	Some	1 study 60 participants

Products

Show 9 more products
Product	Grade	Effect	Evidence	Studies
Purpose Daily Use UV Moisturiser	C	Marked Decrease	Fair	1 study 37 participants
Olay Total Effects 7X Visible Anti-Aging Vitamin Complex	C	Marked Increase	Fair	2 studies 83 participants
Purpose Daily Use UV Moisturiser + Tretinoin	C	Slight Decrease	Fair	1 study 37 participants
Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin	C	Slight Increase	Fair	1 study 37 participants
Isdinceutics Melatonik	D	Marked Increase	Some	1 study 24 participants
Renova	D	Slight Decrease	Some	1 study 188 participants
Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment	D	Slight Increase	Some	1 study 188 participants
Imedeen Time Perfection	D	Potential Decrease	Fair	2 studies 244 participants
Komecera	D	Potential Increase	Some	1 study 50 participants
Imedeen	D	Potential Increase	Some	1 study 111 participants
Pitera	D	Potential Increase	Some	1 study 20 participants
Eucerin UltraWHITE Spotless Double Booster Serum	E	No Effect	Some	1 study 60 participants
Burt's Bees Renewal Refining Cleanser + Burt's Bees Renewal Moisturizing Cream	E	No Effect	Some	1 study 60 participants
Imedeen Derma One	E	No Effect	Fair	1 study 151 participants

Treatments

Coming soon.

Skincare treatments can penetrate more deeply into the skin to provide faster, more dramatic and longer-lasting results than topical products, but they are also much more expensive.

Review all of the scientific evidence before spending thousands of dollars on treatments that won't work, or that make your skin worse due to the side effects.

Log in to register your interest in knowing when information on skincare treatments becomes available on Wisderm.com, and get a 20% discount on launch!

1 Study Found

Intervention	Niacinamide + Sericin + Signaline
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	30

2 Studies Found

Intervention	Tretinoin
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Non-Randomised Controlled
Trial Duration	308 days
Participants	355

Intervention	Tretinoin
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	196

2 Studies Found

Intervention	Gluconolactone
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	28 days
Participants	11

Intervention	Gluconolactone
Concern	Skin Barrier Function
Subject Type	Animal

1 Study Found

Intervention	Tartaric Acid
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	28 days
Participants	11

2 Studies Found

Intervention	Glycolic Acid
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	28 days
Participants	11

Intervention	Glycolic Acid
Concern	Skin Barrier Function
Subject Type	Animal

2 Studies Found

Intervention	Niacinamide
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	56 days
Participants	28

Intervention	Niacinamide
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Randomised Controlled
Trial Duration	28 days
Participants	20

2 Studies Found

Intervention	Lactic Acid
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	28 days
Participants	11

Intervention	Lactic Acid
Concern	Skin Barrier Function
Subject Type	Animal

1 Study Found

Intervention	Retinal
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Non-Randomised Controlled
Trial Duration	308 days
Participants	355

1 Study Found

Intervention	Galactomyces Ferment Filtrate
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	42 days
Participants	20

1 Study Found

Intervention	Retinol
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Non-Randomised Controlled
Trial Duration	308 days
Participants	355

1 Study Found

Intervention	Rice Ceramides
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	50

1 Study Found

Intervention	Lactobionic Acid
Concern	Skin Barrier Function
Subject Type	Animal

1 Study Found

Intervention	Petrolatum
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	56 days
Participants	28

1 Study Found

Intervention	Glycylglycine
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Participants	45

1 Study Found

Intervention	Hyaluronic Acid
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

1 Study Found

Intervention	Hyaluronic Acid + Thiamidol
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

1 Study Found

Intervention	Thiamidol
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

1 Study Found

Intervention	Purpose Daily Use UV Moisturiser
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

2 Studies Found

Intervention	Olay Total Effects 7X Visible Anti-Aging Vitamin Complex
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

Intervention	Olay Total Effects 7X Visible Anti-Aging Vitamin Complex
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	28 days
Participants	50

1 Study Found

Intervention	Purpose Daily Use UV Moisturiser + Tretinoin
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

1 Study Found

Intervention	Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

1 Study Found

Intervention	Isdinceutics Melatonik
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	103

1 Study Found

Intervention	Renova
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	196

1 Study Found

Intervention	Olay Professional Pro-X Age Repair Lotion + Olay Professional Pro-X Wrinkle Smoothing Cream + Olay Professional Pro-X Deep Wrinkle Treatment
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	196

2 Studies Found

Intervention	Imedeen Time Perfection
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	91

Intervention	Imedeen Time Perfection
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	194

1 Study Found

Intervention	Komecera
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	50

1 Study Found

Intervention	Imedeen
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Open-Label Randomised Uncontrolled
Trial Duration	336 days
Participants	144

1 Study Found

Intervention	Pitera
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	42 days
Participants	20

1 Study Found

Intervention	Eucerin UltraWHITE Spotless Double Booster Serum
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

1 Study Found

Intervention	Burt's Bees Renewal Refining Cleanser + Burt's Bees Renewal Moisturizing Cream
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	28 days
Participants	60

1 Study Found

Intervention	Imedeen Derma One
Concern	Skin Barrier Function
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	201

Latest Research

Skin Barrier Function

Coming soon.

1 Study Found

Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing

2 Studies Found

Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen

2 Studies Found

Alpha hydroxyacids modulate stratum corneum barrier function

Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes

1 Study Found

Alpha hydroxyacids modulate stratum corneum barrier function

2 Studies Found

Alpha hydroxyacids modulate stratum corneum barrier function

The effects of topical alpha-hydroxyacids on the normal skin barrier of hairless mice

2 Studies Found

Moisturizing effects of topical nicotinamide on atopic dry skin

Influence of niacinamide containing formulations on the molecular and biophysical properties of the stratum corneum

2 Studies Found

Alpha hydroxyacids modulate stratum corneum barrier function

The effects of topical alpha-hydroxyacids on the normal skin barrier of hairless mice

1 Study Found

Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions

1 Study Found

Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer

1 Study Found

Tolerance profile of retinol, retinaldehyde and retinoic acid under maximized and long-term clinical conditions

1 Study Found

Effect of Rice ( Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study

1 Study Found

Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes

1 Study Found

Moisturizing effects of topical nicotinamide on atopic dry skin

1 Study Found

Glycylglycine decreases the size of conspicuous facial pores: Single-blinded half areas of face-applied study

1 Study Found

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

1 Study Found

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

1 Study Found

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

1 Study Found

Facilitating facial retinization through barrier improvement

2 Studies Found

Facilitating facial retinization through barrier improvement

Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea

1 Study Found

Facilitating facial retinization through barrier improvement

1 Study Found

Facilitating facial retinization through barrier improvement

1 Study Found

Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days

1 Study Found

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen

1 Study Found

A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen

2 Studies Found

A placebo-controlled, double-blind clinical trial to evaluate the efficacy of Imedeen Time Perfection for improving the appearance of photodamaged skin

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women

1 Study Found

Effect of Rice ( Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study

1 Study Found

Imedeen in the treatment of photoaged skin: an efficacy and safety trial over 12 months

1 Study Found

Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer

1 Study Found

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

1 Study Found

Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin

1 Study Found

A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating an Oral Anti-aging Skin Care Supplement for Treating Photodamaged Skin

Effect of Rice ( Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study (2022)

Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer (2022)

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial (2021)

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial (2021)

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial (2021)