The treatment of melasma. 20% azelaic acid versus 4% hydroquinone cream

Efficacy

Intervention(s)	Outcome	Effect	Description
Azelaic Acid	Hyperpigmentation	Decrease	Login to read descriptions for free
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Hydroquinone	Hyperpigmentation	Decrease	Login to read descriptions for free
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Hydroquinone	Melasma	Decrease	Login to read descriptions for free
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Azelaic Acid	Melasma	Decrease	Login to read descriptions for free
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Side Effects

Intervention(s)	Outcome	Effect	Description
Azelaic Acid	Allergic Sensitisation	No Effect	Login to read descriptions for free
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Hydroquinone	Allergic Sensitisation	Increase	Login to read descriptions for free
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Hydroquinone	Irritation	Increase	Login to read descriptions for free
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Azelaic Acid	Irritation	Increase	Login to read descriptions for free
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Hydroquinone	Itching	No Effect	Login to read descriptions for free
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Azelaic Acid	Itching	Increase	Login to read descriptions for free
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Azelaic Acid	Pain	Increase	Login to read descriptions for free
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Hydroquinone	Pain	Increase	Login to read descriptions for free
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Hydroquinone	Peeling	No Effect	Login to read descriptions for free
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Azelaic Acid	Peeling	Increase	Login to read descriptions for free
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Study Design

Subject Type

Human

Trial Design

Double-Blind, Randomised, Controlled

Trial Duration

168 days

Participants

329 (243 completed)

Age Range

18-57 years

Study Summary