Adenosine

What is adenosine?

Adenosine is a purine nucleoside composed of adenine, one of the 4 bases of DNA, associated with a ribose sugar. It is normally present in the skin at low concentrations of between 10 to 200 nM, but its concentration is heightened in hypertrophic or immature scars (R). It is also considered to be a major regulator of adipose tissue physiology, promoting adipogenesis and inhibiting lipolysis (R, R).

Is adenosine stable?

The adenosine content of a dissolvable film containing 1% adenosine was 96% of the initial amount even after 1 month of storage at 45°C, indicating that adenosine is stable (R).

Does adenosine get absorbed?

Adenosine is capable of penetrating human skin (R, R). It can also be applied topically after piercing the skin using microneedle patches (R), or directly loaded onto microneedle patches, to enhance its delivery into the skin (R, R).

What happens after adenosine is absorbed?

Fibroblasts and adipocytes in the skin express adenosine receptors, which adenosine can bind to and activate (R).