Skin Hydration

Ingredients

Show 16 more ingredients
Ingredient	Grade	Effect	Evidence	Studies
Retinol	C	Marked Increase	Fair	2 studies 54 participants
Metronidazole	C	Slight Increase	Fair	1 study 37 participants
Niacinamide + Sericin + Signaline	C	Slight Increase	Fair	1 study 30 participants
Petrolatum	D	Slight Increase	Some	1 study 15 participants
Azelaic Acid + Gluconolactone	D	Slight Increase	Some	1 study 62 participants
Glycylglycine	D	Slight Increase	Some	1 study 24 participants
Pterostilbene	D	Potential Increase	Some	1 study 38 participants
Arbutin + Bisabolol + Niacinamide + Retinal	D	Potential Increase	Some	1 study 33 participants
Ascorbic Acid + Tetrahexyldecyl Ascorbate	D	Potential Increase	Some	1 study 10 participants
Azelaic Acid	D	Potential Decrease	Fair	13 studies 1706 participants
Hyaluronic Acid + Retinal	D	Potential Increase	Some	1 study 1245 participants
Kinetin + Niacinamide	D	Potential Increase	Fair	1 study 27 participants
Rice Ceramides	D	Potential Increase	Some	1 study 50 participants
Ivermectin	D	Potential Increase	Fair	2 studies 2670 participants
DMAE	D	Potential Increase	Fair	2 studies 66 participants
Citric Acid	D	Potential Increase	Some	1 study
Glycolic Acid	D	Potential Increase	Some	2 studies
Ascorbic Acid	D	Potential Increase	Fair	1 study 19 participants
Lactic Acid	D	Potential Increase	Some	2 studies
Galactomyces Ferment Filtrate	D	Potential Increase	Fair	2 studies 124 participants
Niacinamide	E	Mixed Effect	Fair	2 studies 40 participants

Products

Show 19 more products
Product	Grade	Effect	Evidence	Studies
Purpose Daily Use UV Moisturiser	C	Marked Increase	Fair	1 study 37 participants
Imedeen Time Perfection	C	Marked Increase	Fair	3 studies 283 participants
Olay Total Effects 7X Visible Anti-Aging Vitamin Complex	C	Marked Increase	Fair	2 studies 83 participants
Vivida	C	Slight Increase	Fair	1 study 30 participants
Imedeen	C	Slight Increase	Fair	2 studies 60 participants
Purpose Daily Use UV Moisturiser + Tretinoin	C	Slight Increase	Fair	1 study 37 participants
Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin	C	Slight Increase	Fair	1 study 37 participants
Isdinceutics Melatonik	D	Marked Increase	Some	2 studies 48 participants
Viscoderm Pearls	D	Marked Increase	Some	1 study 30 participants
Finacea + NeoStrata Facial Cleanser + NeoStrata Ultra Moisturizing Face Cream	D	Slight Increase	Some	1 study 62 participants
Imedeen Derma One	D	Potential Increase	Fair	1 study 129 participants
Komecera	D	Potential Increase	Some	1 study 50 participants
Pitera	D	Potential Increase	Fair	2 studies 124 participants
Imedeen Man-Age-Ment	D	Potential Increase	Some	1 study 41 participants
La Roche-Posay Active C	D	Potential Increase	Fair	1 study 19 participants
Neora Age IQ Night Cream	D	Potential Increase	Some	1 study 37 participants
Burt's Bees Renewal Refining Cleanser + Burt's Bees Renewal Moisturizing Cream	D	Potential Increase	Some	1 study 60 participants
Avene Eluage Cream	D	Potential Increase	Some	1 study 242 participants
Avene Eluage Cream + Avene Eluage Anti-Wrinkle Concentrate	D	Potential Increase	Some	1 study 1003 participants
PteroWhite	D	Potential Increase	Some	1 study 38 participants
Imedeen Prime Renewal	D	Potential Increase	Fair	1 study 80 participants
Finacea	E	No Effect	Some	2 studies 62 participants
SkinAx²	E	No Effect	Some	1 study 35 participants
Cellex-C High-Potency Serum	E	No Effect	Fair	1 study 38 participants

Treatments

Coming soon.

Skincare treatments can penetrate more deeply into the skin to provide faster, more dramatic and longer-lasting results than topical products, but they are also much more expensive.

Review all of the scientific evidence before spending thousands of dollars on treatments that won't work, or that make your skin worse due to the side effects.

Log in to register your interest in knowing when information on skincare treatments becomes available on Wisderm.com, and get a 20% discount on launch!

2 Studies Found

Intervention	Retinol
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	182 days
Participants	106

Intervention	Retinol
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	36

1 Study Found

Intervention	Metronidazole
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	105 days
Participants	40

1 Study Found

Intervention	Niacinamide + Sericin + Signaline
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	30

1 Study Found

Intervention	Petrolatum
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	56 days
Participants	28

1 Study Found

Intervention	Azelaic Acid + Gluconolactone
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	67

1 Study Found

Intervention	Glycylglycine
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Participants	45

1 Study Found

Intervention	Pterostilbene
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Arbutin + Bisabolol + Niacinamide + Retinal
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	60 days
Participants	35

1 Study Found

Intervention	Ascorbic Acid + Tetrahexyldecyl Ascorbate
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	10

13 Studies Found

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	67

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	252 days
Participants	100

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	116

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	664

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Randomised Controlled
Trial Duration	56 days
Participants	85

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	112 days
Participants	20

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	52

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	105 days
Participants	40

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	252 days
Participants	55

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	961

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	280 days
Participants	1258

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	221

Intervention	Azelaic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	112 days
Participants	20

1 Study Found

Intervention	Hyaluronic Acid + Retinal
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	90 days
Participants	1462

1 Study Found

Intervention	Kinetin + Niacinamide
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	52

1 Study Found

Intervention	Rice Ceramides
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	50

2 Studies Found

Intervention	Ivermectin
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	1371

Intervention	Ivermectin
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	280 days
Participants	1258

2 Studies Found

Intervention	DMAE
Concern	Skin Hydration
Subject Type	Human
Trial Design	Non-Randomised Controlled
Trial Duration	56 days
Participants	36

Intervention	DMAE
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Participants	30

1 Study Found

Intervention	Citric Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Non-Randomised Controlled
Trial Duration	42 days
Participants	10

2 Studies Found

Intervention	Glycolic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Non-Randomised Controlled
Trial Duration	42 days
Participants	10

Intervention	Glycolic Acid
Concern	Skin Hydration
Subject Type	Animal

1 Study Found

Intervention	Ascorbic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	20

2 Studies Found

Intervention	Lactic Acid
Concern	Skin Hydration
Subject Type	Human
Trial Design	Non-Randomised Controlled
Trial Duration	42 days
Participants	10

Intervention	Lactic Acid
Concern	Skin Hydration
Subject Type	Animal

2 Studies Found

Intervention	Galactomyces Ferment Filtrate
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	42 days
Participants	20

Intervention	Galactomyces Ferment Filtrate
Concern	Skin Hydration
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	57 days
Participants	105

2 Studies Found

Intervention	Niacinamide
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	52

Intervention	Niacinamide
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Non-Randomised Controlled
Trial Duration	56 days
Participants	28

1 Study Found

Intervention	Purpose Daily Use UV Moisturiser
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

3 Studies Found

Intervention	Imedeen Time Perfection
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	91

Intervention	Imedeen Time Perfection
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	120 days
Participants	50

Intervention	Imedeen Time Perfection
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	194

2 Studies Found

Intervention	Olay Total Effects 7X Visible Anti-Aging Vitamin Complex
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

Intervention	Olay Total Effects 7X Visible Anti-Aging Vitamin Complex
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	28 days
Participants	50

1 Study Found

Intervention	Vivida
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Participants	30

2 Studies Found

Intervention	Imedeen
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Participants	30

Intervention	Imedeen
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	90 days
Participants	40

1 Study Found

Intervention	Purpose Daily Use UV Moisturiser + Tretinoin
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

1 Study Found

Intervention	Olay Total Effects 7X Visible Anti-Aging Vitamin Complex + Tretinoin
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	50

2 Studies Found

Intervention	Isdinceutics Melatonik
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	168 days
Participants	24

Intervention	Isdinceutics Melatonik
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	103

1 Study Found

Intervention	Viscoderm Pearls
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Randomised Controlled
Trial Duration	28 days
Participants	30

1 Study Found

Intervention	Finacea + NeoStrata Facial Cleanser + NeoStrata Ultra Moisturizing Face Cream
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	67

1 Study Found

Intervention	Imedeen Derma One
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	201

1 Study Found

Intervention	Komecera
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	50

2 Studies Found

Intervention	Pitera
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	42 days
Participants	20

Intervention	Pitera
Concern	Skin Hydration
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	57 days
Participants	105

1 Study Found

Intervention	Imedeen Man-Age-Ment
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	210 days
Participants	47

1 Study Found

Intervention	La Roche-Posay Active C
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	20

1 Study Found

Intervention	Neora Age IQ Night Cream
Concern	Skin Hydration
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Burt's Bees Renewal Refining Cleanser + Burt's Bees Renewal Moisturizing Cream
Concern	Skin Hydration
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	28 days
Participants	60

1 Study Found

Intervention	Avene Eluage Cream
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	90 days
Participants	1462

1 Study Found

Intervention	Avene Eluage Cream + Avene Eluage Anti-Wrinkle Concentrate
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	90 days
Participants	1462

1 Study Found

Intervention	PteroWhite
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Imedeen Prime Renewal
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	100

2 Studies Found

Intervention	Finacea
Concern	Skin Hydration
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	67

Intervention	Finacea
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	112 days
Participants	20

1 Study Found

Intervention	SkinAx²
Concern	Skin Hydration
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	56 days
Participants	35

1 Study Found

Intervention	Cellex-C High-Potency Serum
Concern	Skin Hydration
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	28

Latest Research

Coming soon.

2 Studies Found

Improvement of photoaged facial skin in middle-aged Japanese females by topical retinol (vitamin A alcohol): a vehicle-controlled, double-blind study

Improvement of naturally aged skin with vitamin A (retinol)

1 Study Found

A comparison of topical azelaic acid 20% cream and topical metronidazole 0.75% cream in the treatment of patients with papulopustular rosacea

1 Study Found

Randomized, double-blinded, vehicle-controlled, split-face study to evaluate the effects of topical application of a Gold Silk Sericin/Niacinamide/Signaline complex on biophysical parameters related to skin ageing

1 Study Found

Moisturizing effects of topical nicotinamide on atopic dry skin

1 Study Found

An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients

1 Study Found

Glycylglycine decreases the size of conspicuous facial pores: Single-blinded half areas of face-applied study

1 Study Found

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects

1 Study Found

A novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% for treatment of epidermal melasma

1 Study Found

Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage

13 Studies Found

An evaluation of a polyhydroxy acid skin care regimen in combination with azelaic acid 15% gel in rosacea patients

Beneficial effect of 15% azelaic acid cream on acne vulgaris

Double-blind comparison of azelaic acid 20% cream and its vehicle in treatment of papulo-pustular rosacea

Efficacy and safety of azelaic acid (15%) gel as a new treatment for papulopustular rosacea: results from two vehicle-controlled, randomized phase III studies

Relationship between sebostatic activity, tolerability and efficacy of three topical drugs to treat mild to moderate acne

Efficacy and safety of azelaic acid (AzA) gel 15% in the treatment of post-inflammatory hyperpigmentation and acne: a 16-week, baseline-controlled study

Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients

A comparison of topical azelaic acid 20% cream and topical metronidazole 0.75% cream in the treatment of patients with papulopustular rosacea

A randomized investigator-blind parallel-group study to assess efficacy and safety of azelaic acid 15% gel vs. adapalene 0.1% gel in the treatment and maintenance treatment of female adult acne

A phase 3 randomized, double-blind, vehicle-controlled trial of azelaic acid foam 15% in the treatment of papulopustular rosacea

Long-term safety of ivermectin 1% cream vs azelaic acid 15% gel in treating inflammatory lesions of rosacea: results of two 40-week controlled, investigator-blinded trials

A multicentre, randomized, single-blind, parallel-group study comparing the efficacy and tolerability of benzoyl peroxide 3%/clindamycin 1% with azelaic acid 20% in the topical treatment of mild-to-moderate acne vulgaris

The Efficacy and Safety of Azelaic Acid 15% Foam in the Treatment of Truncal Acne Vulgaris

1 Study Found

Retinaldehyde/hyaluronic acid fragments: a synergistic association for the management of skin aging

1 Study Found

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial

1 Study Found

Effect of Rice ( Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study

2 Studies Found

Efficacy and safety of ivermectin 1% cream in treatment of papulopustular rosacea: results of two randomized, double-blind, vehicle-controlled pivotal studies

Long-term safety of ivermectin 1% cream vs azelaic acid 15% gel in treating inflammatory lesions of rosacea: results of two 40-week controlled, investigator-blinded trials

2 Studies Found

In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation

Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel

1 Study Found

Comparative effectiveness of alpha-hydroxy acids on skin properties

2 Studies Found

Comparative effectiveness of alpha-hydroxy acids on skin properties

The effects of topical alpha-hydroxyacids on the normal skin barrier of hairless mice

1 Study Found

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo

2 Studies Found

Comparative effectiveness of alpha-hydroxy acids on skin properties

The effects of topical alpha-hydroxyacids on the normal skin barrier of hairless mice

2 Studies Found

Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer

Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula

2 Studies Found

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial

Moisturizing effects of topical nicotinamide on atopic dry skin

1 Study Found

Facilitating facial retinization through barrier improvement

3 Studies Found

A placebo-controlled, double-blind clinical trial to evaluate the efficacy of Imedeen Time Perfection for improving the appearance of photodamaged skin

Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women

2 Studies Found

Facilitating facial retinization through barrier improvement

Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea

1 Study Found

Natural cartilage polysaccharides for the treatment of sun-damaged skin in females: a double-blind comparison of Vivida and Imedeen

2 Studies Found

Natural cartilage polysaccharides for the treatment of sun-damaged skin in females: a double-blind comparison of Vivida and Imedeen

Imedeen for the treatment of degenerated skin in females

1 Study Found

Facilitating facial retinization through barrier improvement

1 Study Found