Thiamidol or isobutylamido thiazolyl resorcinol is a skin lightening agent. It was identified by the German company Beiersdorf through first screening 50,000 compounds for inhibitors of human tyrosinase, the rate-limiting enzyme in melanin production, and then optimising the lead compound to develop a derivative with properties compatible with topical formulations (R).
Outcome | Grade | Effect | Studies | |||||||
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Hyperpigmentation |
B
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Melasma |
B
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Skin Barrier Function |
E
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Skin Brightness |
E
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Outcome | Grade | Effect | Studies | |||||||
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Tyrosinase |
D
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Melanin |
E
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