Thiamidol

Introduction

What is thiamidol?

Thiamidol or isobutylamido thiazolyl resorcinol is a skin lightening agent. It was identified by the German company Beiersdorf through first screening 50,000 compounds for inhibitors of human tyrosinase, the rate-limiting enzyme in melanin production, and then optimising the lead compound to develop a derivative with properties compatible with topical formulations (R).

Efficacy
Outcome Grade Effect Studies
Hyperpigmentation
B
  • ๐Ÿ ซ
Melasma
B
  • ๐Ÿ ซ
Skin Barrier Function
E
  • โ€“
Skin Brightness
E
  • โ€“
Mechanisms
Outcome Grade Effect Studies
Tyrosinase
D
  • ๐Ÿ ซ๐Ÿ ซ๐Ÿ ซ
Melanin
E
  • โ€“
Side Effects
Outcome Effect Frequency Studies
Itching โ‡ง โ€”
Skin Redness โ‡ง
  • 4%
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