Skin Brightness

The Clinical Efficacy and Tolerability of a Novel Retinaldehyde Serum with Firming Peptides to Improve Skin Texture and Signs of Photoaging (2024)

A Novel Protection and Repair Skincare Regimen Shows Efficacy for Improving Environmental Skin Aging (2024)

Efficacy of isobutylamido thiazolyl resorcinol for prevention of laser-induced post-inflammatory hyperpigmentation: A randomized, controlled trial (2024)

Efficacy and tolerability of a depigmenting gel serum comprising tranexamic acid, niacinamide, 4-butylresorcinol, phytic acid, and a mixture of hydroxy acids that targets the biological processes regulating skin melanogenesis (2024)

Effectiveness and tolerance of multicorrective topical treatment for infraorbital dark circles and puffiness (2024)

Multicenter evaluation of a topical antioxidant serum (2024)

Skin-Whitening Effect of a Callus Extract of Nelumbo nucifera Isolate Haman (2023)

The effect of Salix alba L. bark extract on dark circles in vitro and in vivo (2023)

Evaluation of the Reduction of Skin Hyperpigmentation Changes under the Influence of a Preparation Containing Kojic Acid Using Hyperspectral Imaging-Preliminary Study (2023)

Evaluation of a New, Advanced Antioxidant Containing Topical Allyl Pyrroloquinoline Quinone: Analysis of Antioxidant Properties and Visible Effects in Subjects with Facial Photodamage (2023)

A Multi-Center, Randomized, Blinded Clinical Study Evaluating the Efficacy and Safety of a Novel Topical Product for Facial Dyschromia (2023)

Impact of defensins-containing body cream on skin composition (2023)

Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months-An 11-Year Longitudinal Skin Aging Rejuvenation Study (2023)

Benefits of the Dermocosmetic Mineral 89 Probiotic Fractions Adjunct to Topical Retinoids for Anti-Aging Benefits (2023)

Protective effects of a day/night dual-antioxidant serum on skin: A randomized, regimen-controlled study in Chinese women exposed to air pollution (2023)

Efficacy Evaluation of a Cosmetic Product for the Periocular Area in Caucasian Women Aged Over 40 Years Old (2022)

An Open-Label Clinical Trial Analyzing the Efficacy of a Novel Telomere-Protecting Antiaging Face Cream (2022)

Topical formulation containing peptides and vitamin C in ampoules improves skin aging signs: Results of a large, international, observational study (2022)

Efficacy and tolerability of a hyaluronic acid-based serum and a peptide-rich cream for the face and neck in subjects with photodamaged skin (2022)

An Open-Label Study Assessing the Efficacy and Tolerability of a Skincare Regimen in Subjects of Different Ethnicities with Moderate-to-Severe Hyperpigmentation (2022)

A Prospective, Randomized, Double-Blind, Vehicle-Controlled Study Evaluating the Efficacy, Safety, and Patient Satisfaction of Tretinoin 0.05% Lotion for Chest Rejuvenation (2022)

An open-label, investigator-initiated, single-center, prospective, pilot clinical study to evaluate the efficacy of a skin whitening serum applied twice daily combined with a spot-preventing SPF50+ sunscreen in healthy female subjects with melasma hyperpigmentation (2022)

The study of skin hydration, anti-wrinkles function improvement of anti-aging cream with alpha-ketoglutarate (2022)

Superior even skin tone and anti-ageing benefit of a combination of 4-hexylresorcinol and niacinamide (2022)

A dermocosmetic formulation containing Vichy volcanic mineralizing water, Vitreoscilla filiformis extract, niacinamide, hyaluronic acid, and vitamin E regenerates and repairs acutely stressed skin (2022)

Thiamidol® in moderate-to-severe melasma: 24-week, randomized, double-blind, vehicle-controlled clinical study with subsequent regression phase (2021)

A pilot study evaluating the efficacy and tolerability of a comprehensive, hydrating topical antioxidant developed specifically for men (2021)

Effective reduction of post-inflammatory hyperpigmentation with the tyrosinase inhibitor isobutylamido-thiazolyl-resorcinol (Thiamidol) (2021)

The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color (2021)

Effectiveness of a formulation containing peptides and vitamin C in treating signs of facial ageing: three clinical studies (2021)

Oral Pycnogenol® Intake Benefits the Skin in Urban Chinese Outdoor Workers: A Randomized, Placebo-Controlled, Double-Blind, and Crossover Intervention Study (2021)

Isobutylamido thiazolyl resorcinol for prevention of UVB-induced hyperpigmentation (2021)

A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity (2021)

Efficacy and Tolerability of a Novel Topical Treatment for Neck: A Randomized, Double-blind, Regimen-Controlled Study (2021)

Night Cream Containing Melatonin, Carnosine and Helichrysum italicum Extract Helps Reduce Skin Reactivity and Signs of Photodamage: Ex Vivo and Clinical Studies (2020)

Clinical Benefits of Circadian-based Antioxidant Protection and Repair (2020)

Clinical Evaluation of a Nature-Based Bakuchiol Anti-Aging Moisturizer for Sensitive Skin (2020)

A novel skin brightening topical technology (2020)

Thiamidol containing treatment regimens in facial hyperpigmentation: An international multi-centre approach consisting of a double-blind, controlled, split-face study and of an open-label, real-world study (2020)

Amazake made from sake cake and rice koji suppresses sebum content in differentiated hamster sebocytes and improves skin properties in humans (2020)

Effect of defensins-containing eye cream on periocular rhytids and skin quality (2020)

Efficacy of a Dermocosmetic Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin Photoaging in vitro and to Improve Clinical Outcomes for Naturally Aged Skin (2020)

Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis (2020)

A Dermonutrient Containing Special Collagen Peptides Improves Skin Structure and Function: A Randomized, Placebo-Controlled, Triple-Blind Trial Using Confocal Laser Scanning Microscopy on the Cosmetic Effects and Tolerance of a Drinkable Collagen Supplement (2020)

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects (2020)

Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals (2019)

SIG-1273 protects skin against urban air pollution and when formulated in AgeIQ™ Night Cream anti-aging benefits clinically demonstrated (2019)

Novel Hydrolyzed Chicken Sternal Cartilage Extract Improves Facial Epidermis and Connective Tissue in Healthy Adult Females: A Randomized, Double-Blind, Placebo-Controlled Trial (2019)

Long-term objective assessments of skin rejuvenation using solar protection and solar repair shown through digital facial surface analysis and three-dimensional volumetric assessment (2019)

Evaluation of the safety and efficacy of a triple combination cream (hydroquinone, tretinoin, and fluocinolone) for treatment of melasma in Middle Eastern skin (2019)

Whitening effect of L-ascorbate-2-phosphate trisodium salt on solar lentigos (2019)

A single-center clinical trial to evaluate the efficacy of a tripeptide/hexapeptide antiaging regimen (2019)

Evaluation of the efficacy of a new hyaluronic acid gel on dynamic and static wrinkles in volunteers with moderate aging/photoaging (2019)

Brightening and Improvement of Facial Skin Quality in Healthy Female Subjects With Moderate Hyperpigmentation or Dark Spots and Moderate Facial Aging (2018)

Antiaging efficacy of a retinaldehyde-based cream compared with glycolic acid peel sessions: A randomized controlled study (2018)

A single-center, pilot study evaluating a novel TriHex peptide- and botanical-containing eye treatment compared to baseline (2018)

Multi-Center, Double-Blind, Vehicle-Controlled Clinical Trial of an Alpha and Beta Defensin-Containing Anti-Aging Skin Care Regimen With Clinical, Histopathologic, Immunohistochemical, Photographic, and Ultrasound Evaluation (2018)

Oral hyaluronan relieves wrinkles: a double-blinded, placebo-controlled study over a 12-week period (2017)

Assessment of the efficacy and safety of a new complex skin cream in Asian women: A controlled clinical trial (2017)

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women (2017)

Clinical effects of an oral supplement rich in antioxidants on skin radiance in women (2016)

Efficacy and possible mechanisms of topical tranexamic acid in melasma (2016)

A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females (2016)

In vitro and clinical evaluation of SIG1273: a cosmetic functional ingredient with a broad spectrum of anti-aging and antioxidant activities (2016)

A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating an Oral Anti-aging Skin Care Supplement for Treating Photodamaged Skin (2016)

Assessment of a Novel Anti-Aging Hand Cream (2016)

An Open Label Clinical Trial to Evaluate the Efficacy and Tolerance of a Retinol and Vitamin C Facial Regimen in Women With Mild-to-Moderate Hyperpigmentation and Photodamaged Facial Skin (2016)

4-n-butylresorcinol dissolving microneedle patch for skin depigmentation: a randomized, double-blind, placebo-controlled trial (2016)

A placebo-controlled, double-blind clinical trial to evaluate the efficacy of Imedeen Time Perfection for improving the appearance of photodamaged skin (2016)

Rejuvenating Hydrator: Restoring Epidermal Hyaluronic Acid Homeostasis With Instant Benefits (2016)

A novel cream formulation containing nicotinamide 4%, arbutin 3%, bisabolol 1%, and retinaldehyde 0.05% for treatment of epidermal melasma (2015)

Facial primer provides immediate and long-term improvements in mild-to-moderate facial hyperpigmentation and fine lines associated with photoaging (2015)

Long-term Multi-product Facial Regimen in Subjects with Moderate-to-severe Photodamage and Hyperpigmentation (2015)

An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin (2015)

4-Hexyl-1,3-phenylenediol, a nuclear factor-κB inhibitor, improves photodamaged skin and clinical signs of ageing in a double-blinded, randomized controlled trial (2015)

Assessment of clinical effects and safety of an oral supplement based on marine protein, vitamin C, grape seed extract, zinc, and tomato extract in the improvement of visible signs of skin aging in men (2015)

Assessment of the safety and efficacy of topical copper chlorophyllin in women with photodamaged facial skin (2015)

One-year topical stabilized retinol treatment improves photodamaged skin in a double-blind, vehicle-controlled trial (2015)

A randomized, double-blind, split-face study comparing the efficacy and tolerability of three retinol-based products vs. three tretinoin-based products in subjects with moderate to severe facial photodamage (2015)

Clinical efficacy and safety of 4-hexyl-1,3-phenylenediol for improving skin hyperpigmentation (2014)

Hydroquinone-free Skin Brightener System for the Treatment of Moderate-to-severe Facial Hyperpigmentation (2014)

Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial (2014)

Effects of Resveratrol and Collagen Supplementation on Facial Aging (2014)

Efficacy of a novel treatment serum in the improvement of photodamaged skin (2013)

Efficacy of hydroquinone-free skin-lightening cream for photoaging (2013)

The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites (2013)

Instrumental and clinical studies of the facial skin tone and pigmentation of Shanghaiese women. Changes induced by age and a cosmetic whitening product (2012)

Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin (2012)

Efficacy of a novel hydroquinone-free skin-brightening cream in patients with melasma (2011)

Evaluation of a kojic acid, emblica extract, and glycolic acid formulation compared with hydroquinone 4% for skin lightening (2010)

An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging (2010)

Combination of physiologically balanced growth factors with antioxidants for reversal of facial photodamage (2010)

Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin (2008)

A novel treatment option for photoaged skin (2008)

Antiaging Effects of Topical Lactobionic Acid: Results of A Controlled Usage Study (2008)

Topical manganese peptide in the treatment of photodamaged skin (2007)

Efficacy of a soy moisturizer in photoaging: a double-blind, vehicle-controlled, 12-week study (2007)

Evaluation of efficacy and safety of rucinol serum in patients with melasma: a randomized controlled trial (2007)

Efficacy and tolerability of kinetin 0.1% cream for improving the signs of photoaging in facial and neck skin (2006)

4-(1-Phenylethyl) 1,3-benzenediol: a new highly potent lightening agent (2006)

Niacinamide-containing facial moisturizer improves skin barrier and benefits subjects with rosacea (2005)

Long-term efficacy and safety of tretinoin emollient cream 0.05% in the treatment of photodamaged facial skin: a two-year, randomized, placebo-controlled trial (2005)

Topical niacinamide reduces yellowing, wrinkling, red blotchiness, and hyperpigmented spots in aging facial skin (2004)

A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen (2004)

The use of polyhydroxy acids (PHAs) in photoaged skin (2004)

Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo (2003)

Reversal of photodamage with topical growth factors: a pilot study (2003)

The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer (2002)

Utilization of a high-resolution digital imaging system for the objective and quantitative assessment of hyperpigmented spots on the face (2002)

Topical 5% alpha lipoic acid cream in the treatment of cutaneous rhytids (2000)

Use of topical ascorbic acid and its effects on photodamaged skin topography (1999)

Alpha hydroxyacids modulate stratum corneum barrier function (1997)

Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind vehicle-controlled clinical trial (1996)

Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo (1996)

Mechanism of action of a lipophilic derivative of salicylic acid on normal skin (1995)

Topical tretinoin (retinoic acid) treatment of hyperpigmented lesions associated with photoaging in Chinese and Japanese patients: a vehicle-controlled trial (1994)

Tretinoin emollient cream 0.01% for the treatment of photoaged skin (1993)

An oral approach to the treatment of photodamaged skin: a pilot study (1992)

Tretinoin emollient cream: a new therapy for photodamaged skin (1992)

Topical tretinoin for treatment of photodamaged skin. A multicenter study (1991)

Treatment of photodamaged facial skin with topical tretinoin (1989)