Melanin

Ingredients

Show 10 more ingredients
Ingredient	Grade	Effect	Evidence	Studies
Tretinoin	C	Marked Decrease	Fair	2 studies 183 participants
N-Acetyl Glucosamine + Niacinamide	C	Slight Decrease	Fair	1 study 188 participants
Hyaluronic Acid	D	Slight Increase	Some	1 study 60 participants
Adapalene	D	Potential Decrease	Some	1 study 36 participants
Centella Asiatica Extract + Galactomyces Ferment Filtrate + Panthenol	D	Potential Decrease	Good	1 study 51 participants
Niacinamide + Tranexamic Acid	D	Potential Decrease	Fair	1 study 42 participants
Linoleic Acid + Niacinamide + Oxidised Glutathione + Oxyresveratrol + Tranexamic Acid	D	Potential Decrease	Some	1 study 26 participants
Rice Ceramides	D	Potential Decrease	Some	1 study 50 participants
Tranexamic Acid	E	Marked Decrease	Basic	1 study
Kojic Acid	E	Slight Decrease	Basic	1 study
Pterostilbene	E	Slight Decrease	Basic	1 study
Hyaluronic Acid + Thiamidol	E	No Effect	Some	1 study 60 participants
Kinetin + Niacinamide	E	No Effect	Fair	1 study 27 participants
Thiamidol	E	No Effect	Some	1 study 60 participants
Niacinamide	E	No Effect	Fair	2 studies 25 participants

Products

Show 2 more products
Product	Grade	Effect	Evidence	Studies
Renova	C	Marked Decrease	Fair	1 study 146 participants
Retin-A	C	Marked Decrease	Fair	1 study 37 participants
Aestura Regederm RX White Project	D	Potential Decrease	Fair	1 study 42 participants
Komecera	D	Potential Decrease	Some	1 study 50 participants
SkinCeuticals Discoloration Defense	D	Potential Decrease	Some	1 study 55 participants
PteroWhite	E	Slight Decrease	Basic	1 study
Eucerin UltraWHITE Spotless Double Booster Serum	E	No Effect	Some	1 study 60 participants

Treatments

Coming soon.

Skincare treatments can penetrate more deeply into the skin to provide faster, more dramatic and longer-lasting results than topical products, but they are also much more expensive.

Review all of the scientific evidence before spending thousands of dollars on treatments that won't work, or that make your skin worse due to the side effects.

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2 Studies Found

Intervention	Tretinoin
Concern	Melanin
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

Intervention	Tretinoin
Concern	Melanin
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	280 days
Participants	50

1 Study Found

Intervention	N-Acetyl Glucosamine + Niacinamide
Concern	Melanin
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	70 days
Participants	202

1 Study Found

Intervention	Hyaluronic Acid
Concern	Melanin
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

1 Study Found

Intervention	Adapalene
Concern	Melanin
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	252 days
Participants	90

1 Study Found

Intervention	Centella Asiatica Extract + Galactomyces Ferment Filtrate + Panthenol
Concern	Melanin
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	51

1 Study Found

Intervention	Niacinamide + Tranexamic Acid
Concern	Melanin
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	42

1 Study Found

Intervention	Linoleic Acid + Niacinamide + Oxidised Glutathione + Oxyresveratrol + Tranexamic Acid
Concern	Melanin
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	26

1 Study Found

Intervention	Rice Ceramides
Concern	Melanin
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	50

1 Study Found

Intervention	Tranexamic Acid
Concern	Melanin
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	55

1 Study Found

Intervention	Kojic Acid
Concern	Melanin
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Pterostilbene
Concern	Melanin
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Hyaluronic Acid + Thiamidol
Concern	Melanin
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

1 Study Found

Intervention	Kinetin + Niacinamide
Concern	Melanin
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	52

1 Study Found

Intervention	Thiamidol
Concern	Melanin
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

2 Studies Found

Intervention	Niacinamide
Concern	Melanin
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	138

Intervention	Niacinamide
Concern	Melanin
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	84 days
Participants	52

1 Study Found

Intervention	Renova
Concern	Melanin
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

1 Study Found

Intervention	Retin-A
Concern	Melanin
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	280 days
Participants	50

1 Study Found

Intervention	Aestura Regederm RX White Project
Concern	Melanin
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	56 days
Participants	42

1 Study Found

Intervention	Komecera
Concern	Melanin
Subject Type	Human
Trial Design	Open-Label Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	50

1 Study Found

Intervention	SkinCeuticals Discoloration Defense
Concern	Melanin
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	84 days
Participants	55

1 Study Found

Intervention	PteroWhite
Concern	Melanin
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	56 days
Participants	39

1 Study Found

Intervention	Eucerin UltraWHITE Spotless Double Booster Serum
Concern	Melanin
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	84 days
Participants	92

Latest Research

Coming soon.

2 Studies Found

Topical tretinoin for treatment of photodamaged skin. A multicenter study

Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial

1 Study Found

Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial

1 Study Found

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

1 Study Found

Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial

1 Study Found

The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color

1 Study Found

Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial

1 Study Found

Assessment of the efficacy and safety of a new complex skin cream in Asian women: A controlled clinical trial

1 Study Found

Effect of Rice ( Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study

1 Study Found

Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation

1 Study Found

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects

1 Study Found

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects

1 Study Found

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

1 Study Found

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial

1 Study Found

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

2 Studies Found

The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

The clinical anti-aging effects of topical kinetin and niacinamide in Asians: a randomized, double-blind, placebo-controlled, split-face comparative trial

1 Study Found

Topical tretinoin for treatment of photodamaged skin. A multicenter study

1 Study Found

Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial

1 Study Found

Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial

1 Study Found

Effect of Rice ( Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study

1 Study Found

Effect of a Tranexamic Acid, Kojic Acid, and Niacinamide Containing Serum on Facial Dyschromia: A Clinical Evaluation

1 Study Found

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects

1 Study Found

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial

Effect of Rice ( Oryza sativa L.) Ceramides Supplementation on Improving Skin Barrier Functions and Depigmentation: An Open-Label Prospective Study (2022)

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial (2021)

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial (2021)

Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial (2021)

The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color (2021)