Retinyl propionate and climbazole combination demonstrates clinical improvement to the appearance of hyperpigmentation and deep wrinkling with minimal irritation

Study Design

Subject Type

Human

Trial Design

Double-Blind, Randomised, Controlled

Trial Duration

112 days

Participants

68

Age Range

20-70 years

Efficacy

Intervention(s)			Outcome		Method		Effect	Description
Climbazole + Retinyl Propionate			Fine Lines		Clinical grading		⇩	Sign in to read for free
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Retinol			Fine Lines		Clinical grading		⇩	Sign in to read for free
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Climbazole + Retinyl Propionate			Hyperpigmentation		Clinical grading		⇩	Sign in to read for free
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Retinol			Hyperpigmentation		Clinical grading		⇩	Sign in to read for free
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Climbazole + Retinyl Propionate			Skin Firmness		Self-assessment		⇧	Sign in to read for free
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Climbazole + Retinyl Propionate			Skin Smoothness		PRIMOS		⇧	Sign in to read for free
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Climbazole + Retinyl Propionate			Wrinkles		PRIMOS		⇩	Sign in to read for free
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Climbazole + Retinyl Propionate			Wrinkles		Clinical grading		⇩	Sign in to read for free
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Retinol			Wrinkles		Clinical grading		⇩	Sign in to read for free
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Mechanisms

Intervention(s)			Outcome		Method		Effect	Description
Retinol			Melanin		SIAscopy		⇩	Sign in to read for free
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Climbazole + Retinyl Propionate			Melanin		SIAscopy		⇩	Sign in to read for free
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Side Effects

Intervention(s)			Outcome		Effect	Description
Climbazole + Retinyl Propionate			Irritation		⇧	Sign in to read for free
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Retinol			Irritation		⇧	Sign in to read for free
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Retinyl Propionate			Irritation		–	Sign in to read for free
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Study Summary

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