RATIONALE The Essential Six

Efficacy

Show 5 more outcomes
Outcome				Grade		Effect		Evidence		Studies
Skin Firmness				C		⇧ Potential		★★★ Fair		2 studies 48 participants
Skin Brightness				C		⇧ Potential		★★★ Fair		2 studies 48 participants
Hyperpigmentation				C		⇩ Potential		★★ Some		2 studies 48 participants
Skin Smoothness				C		⇧ Potential		★★★ Fair		2 studies 48 participants
Skin Redness				C		⇩ Potential		★★ Some		2 studies 48 participants
Fine Lines				C		⇩ Potential		★★ Some		1 study 30 participants
Skin Barrier Function				C		⇩ Potential		★★ Some		1 study 30 participants
Skin Hydration				C		⇧ Potential		★★ Some		1 study 30 participants
Wrinkles				E		– No Effect		★★ Some		1 study 30 participants
Skin Elasticity				E		– No Effect		★★ Some		1 study 30 participants

Side Effects

Outcome			Effect		Frequency			Studies
Itching			⇧ Increase		17% (3 out of 18 participants)			1 study
Pain			⇧ Increase		17% (3 out of 18 participants)			1 study
Skin Hydration			⇩ Decrease		—			1 study
Skin Discomfort			⇧ Increase		—			1 study

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