Skin Thickness

Ingredients

Show 6 more ingredients
Ingredient	Grade	Effect	Evidence	Studies
Tretinoin	C	Marked Increase	Fair	3 studies 220 participants
Retinal	C	Marked Increase	Fair	3 studies 40 participants
Retinyl Palmitate	D	Marked Increase	Some	1 study
Retinol	D	Marked Increase	Some	1 study
Niacinamide	D	Marked Increase	Some	1 study 20 participants
Glycolic Acid	D	Notable Increase	Some	3 studies 11 participants
Lactic Acid	D	Notable Increase	Some	3 studies 11 participants
Citric Acid	D	Slight Increase	Some	1 study 7 participants
Ascorbic Acid + Tetrahexyldecyl Ascorbate	D	Potential Increase	Some	1 study 4 participants
DMAE	E	Marked Increase	Basic	2 studies
Adapalene	E	No Effect	Some	1 study 36 participants

Products

Show 3 more products
Product	Grade	Effect	Evidence	Studies
Retin-A	C	Marked Increase	Fair	2 studies 65 participants
Vivida	C	Slight Increase	Fair	1 study 30 participants
Imedeen Derma One	C	Slight Increase	Fair	1 study 141 participants
Renova	C	Slight Increase	Fair	1 study 155 participants
Imedeen	C	Slight Increase	Fair	4 studies 177 participants
Imedeen Prime Renewal	D	Potential Decrease	Fair	1 study 80 participants
Imedeen Time Perfection	E	No Effect	Fair	1 study 171 participants
Isdinceutics Melatonik	E	No Effect	Some	1 study 5 participants

Treatments

Coming soon.

Skincare treatments can penetrate more deeply into the skin to provide faster, more dramatic and longer-lasting results than topical products, but they are also much more expensive.

Review all of the scientific evidence before spending thousands of dollars on treatments that won't work, or that make your skin worse due to the side effects.

Log in to register your interest in knowing when information on skincare treatments becomes available on Wisderm.com, and get a 20% discount on launch!

3 Studies Found

Intervention	Tretinoin
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

Intervention	Tretinoin
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	40

Intervention	Tretinoin
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	280 days
Participants	50

3 Studies Found

Intervention	Retinal
Concern	Skin Thickness
Subject Type	Human
Trial Design	Non-Randomised Controlled

Intervention	Retinal
Concern	Skin Thickness
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	365 days
Participants	44

Intervention	Retinal
Concern	Skin Thickness
Subject Type	Human
Trial Design	Non-Randomised Controlled

1 Study Found

Intervention	Retinyl Palmitate
Concern	Skin Thickness
Subject Type	Human
Trial Design	Non-Randomised Controlled

1 Study Found

Intervention	Retinol
Concern	Skin Thickness
Subject Type	Human
Trial Design	Non-Randomised Controlled

1 Study Found

Intervention	Niacinamide
Concern	Skin Thickness
Subject Type	Human
Trial Design	Randomised Controlled
Trial Duration	28 days
Participants	20

3 Studies Found

Intervention	Glycolic Acid
Concern	Skin Thickness
Subject Type	Human
Trial Design	Non-Randomised Controlled
Trial Duration	42 days
Participants	10

Intervention	Glycolic Acid
Concern	Skin Thickness
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	17

Intervention	Glycolic Acid
Concern	Skin Thickness
Subject Type	Animal

3 Studies Found

Intervention	Lactic Acid
Concern	Skin Thickness
Subject Type	Human
Trial Design	Non-Randomised Controlled
Trial Duration	42 days
Participants	10

Intervention	Lactic Acid
Concern	Skin Thickness
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	17

Intervention	Lactic Acid
Concern	Skin Thickness
Subject Type	Animal

1 Study Found

Intervention	Citric Acid
Concern	Skin Thickness
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	168 days
Participants	17

1 Study Found

Intervention	Ascorbic Acid + Tetrahexyldecyl Ascorbate
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Non-Randomised Controlled
Trial Duration	84 days
Participants	10

2 Studies Found

Intervention	DMAE
Concern	Skin Thickness
Subject Type	Human
Trial Design	Non-Randomised Controlled
Trial Duration	56 days
Participants	36

Intervention	DMAE
Concern	Skin Thickness
Subject Type	Animal

1 Study Found

Intervention	Adapalene
Concern	Skin Thickness
Subject Type	Human
Trial Design	Single-Blind Randomised Controlled
Trial Duration	252 days
Participants	90

2 Studies Found

Intervention	Retin-A
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	40

Intervention	Retin-A
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	280 days
Participants	50

1 Study Found

Intervention	Vivida
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Participants	30

1 Study Found

Intervention	Imedeen Derma One
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	112 days
Participants	201

1 Study Found

Intervention	Renova
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	299

4 Studies Found

Intervention	Imedeen
Concern	Skin Thickness
Subject Type	Human
Trial Design	Open-Label Randomised Uncontrolled
Trial Duration	336 days
Participants	144

Intervention	Imedeen
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Participants	30

Intervention	Imedeen
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	90 days
Participants	40

Intervention	Imedeen
Concern	Skin Thickness
Subject Type	Human
Trial Design	Non-Randomised Uncontrolled
Trial Duration	90 days
Participants	6

1 Study Found

Intervention	Imedeen Prime Renewal
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	100

1 Study Found

Intervention	Imedeen Time Perfection
Concern	Skin Thickness
Subject Type	Human
Trial Design	Double-Blind Randomised Controlled
Trial Duration	168 days
Participants	194

1 Study Found

Intervention	Isdinceutics Melatonik
Concern	Skin Thickness
Subject Type	Human
Trial Design	Open-Label Non-Randomised Controlled
Trial Duration	168 days
Participants	24

Latest Research

Coming soon.

3 Studies Found

Topical tretinoin for treatment of photodamaged skin. A multicenter study

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study

Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial

3 Studies Found

Biological activities of topical retinaldehyde

Efficacy of topical 0.05% retinaldehyde in skin aging by ultrasound and rheological techniques

Unoccluded retinol penetrates human skin in vivo more effectively than unoccluded retinyl palmitate or retinoic acid

1 Study Found

Unoccluded retinol penetrates human skin in vivo more effectively than unoccluded retinyl palmitate or retinoic acid

1 Study Found

Unoccluded retinol penetrates human skin in vivo more effectively than unoccluded retinyl palmitate or retinoic acid

1 Study Found

Influence of niacinamide containing formulations on the molecular and biophysical properties of the stratum corneum

3 Studies Found

Comparative effectiveness of alpha-hydroxy acids on skin properties

Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study

The effects of topical alpha-hydroxyacids on the normal skin barrier of hairless mice

3 Studies Found

Comparative effectiveness of alpha-hydroxy acids on skin properties

Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study

The effects of topical alpha-hydroxyacids on the normal skin barrier of hairless mice

1 Study Found

Effects of alpha-hydroxy acids on photoaged skin: a pilot clinical, histologic, and ultrastructural study

1 Study Found

Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage

2 Studies Found

In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation

The antiwrinkle effect of topical concentrated 2-dimethylaminoethanol involves a vacuolar cytopathology

1 Study Found

Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial

2 Studies Found

Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study

Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial

1 Study Found

Natural cartilage polysaccharides for the treatment of sun-damaged skin in females: a double-blind comparison of Vivida and Imedeen

1 Study Found

A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating an Oral Anti-aging Skin Care Supplement for Treating Photodamaged Skin

1 Study Found

Topical tretinoin for treatment of photodamaged skin. A multicenter study

4 Studies Found

Imedeen in the treatment of photoaged skin: an efficacy and safety trial over 12 months

Natural cartilage polysaccharides for the treatment of sun-damaged skin in females: a double-blind comparison of Vivida and Imedeen

Imedeen for the treatment of degenerated skin in females

An oral approach to the treatment of photodamaged skin: a pilot study

1 Study Found

Effect of a novel dietary supplement on skin aging in post-menopausal women

1 Study Found

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women

1 Study Found

Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis

Efficacy and safety of a 3-in-1 antiaging night facial serum containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate through clinical and histological analysis (2020)

A multicenter, placebo-controlled, double-blind clinical trial assessing the effects of a multicomponent nutritional supplement for treating photoaged skin in healthy women (2017)

A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating an Oral Anti-aging Skin Care Supplement for Treating Photodamaged Skin (2016)

Influence of niacinamide containing formulations on the molecular and biophysical properties of the stratum corneum (2013)

In vivo skin effects of a dimethylaminoethanol (DMAE) based formulation (2009)